Results 1 to 10 of about 1,481 (119)

Hypoxia-induced TPC2 transcription and glycosylation aggravates pulmonary arterial hypertension by blocking autophagy flux [PDF]

Scientific Reports
Pulmonary arterial hypertension (PAH) is a serious medical condition that causes a failure in the right heart. Two-pore channel 2 (TPC2) is upregulated in PAH, but its roles in PAH remain largely unknown. Our investigation aims at the mechanisms by which
Chao Li, Cheng Li, YuFei Jiang, MoFei Liu, ChengYi Yang, JiaXin Lu, YongLiang Jiang   +6 more
exaly   +3 more sources

O-linked glycan-dependent gating of TPC2 controls lysosomal excitability and organelle remodeling [PDF]

Nature Communications
Two-pore channel 2 (TPC2) is a lysosomal cation channel involved in calcium and sodium signaling and membrane remodeling. Its dysfunction has been linked to diseases including viral infections, neurodegenerative disorders, and cancer.
Alice Lin, Neng-Yu Lin, Marco Keller, Ramona Schütz, Yi-Zhen Wu, William Burton, Novelyn Putri Kinanti, Chi-Yuan Yao, Nicole Urban, Ya-Wen Liu, Franz Bracher, Antony Galione, Hao-Jen Hsu, Ching-Ying Kuo, Cheng-Chang Chen   +14 more
doaj   +2 more sources

Insights Into Aggregation-Delayed Phenotype of Dictyostelium discoideum. [PDF]

Cell Biol Int
ABSTRACT Dictyostelium discoideum is a cellular model that has been widely used in cell signal research focusing on different cellular and developmental processes. The unique lifecycle of these cells—which involves switching between vegetative and development phases—makes Dictyostelium a reliable model for investigations in this field.
Alamer SA.
europepmc   +2 more sources

TPC2 regulates proteomic remodeling, bioenergetic phenotypes, and mitochondrial stress adaptation in melanoma [PDF]

Saudi Pharmaceutical Journal
Melanoma is a highly heterogeneous malignancy in which tumor behavior is shaped by complex signaling, trafficking, and metabolic programs. Two-pore channel 2 (TPC2), an endolysosomal ion channel, has been implicated in pigmentation, vesicular trafficking,
Homood M. As Sobeai, Ali Hanbashi, Lama Binobaid, Khalid Alhazzani, Sarah M. Almufadhili, Ahmed Altuwaijri, Rashed Almousa, Faroq Kamli, Sulaiman S. Alhudaithi, Moureq Alotaibi, John Parrington   +10 more
doaj   +2 more sources

Two-pore channel-2 controls calmodulin-dependent STIM1 inactivation [PDF]

Nature Communications
Lysosomal two-pore channels (TPC) trigger Ca2+ release from the endoplasmic reticulum (ER). The ensuing ER Ca2+ depletion activates STIM1-gated store-operated Ca2+ entry (SOCE) channels that sustain Ca2+ signals regulating fundamental cellular processes.
Subo Lee, Raphael Néré, Kyoung Sun Park, Vincent Jaquet, Nicolas Demaurex, Kyu-Sang Park   +5 more
doaj   +2 more sources

MYB59 is Linked to Natural Variation of Water-Use Associated With Warmer Temperatures in <i>Arabidopsis thaliana</i>. [PDF]

Plant Environ Interact
ABSTRACT Water‐use contributes significantly to plant growth and productivity, yet the extent to which variation in water‐use is a function of adaptive differentiation is unknown. Here, we studied natural variation of water use in Arabidopsis thaliana to understand how climatic history impacts water‐use strategies.
Ferguson JN, Brendel O, Bechtold U.
europepmc   +2 more sources

Pharmacological inhibition of lysosomal two-pore channel 2 (TPC2) confers neuroprotection in stroke via autophagy regulation

Neurobiology of Disease, 2023
Lysosomal function and organellar Ca2+ homeostasis become dysfunctional in Stroke causing disturbances in autophagy, the major process for the degradation of abnormal protein aggregates and dysfunctional organelles.
Agnese Secondo, Maria José Sisalli, Valentina Tedeschi   +2 more
exaly   +3 more sources

Regulation of Ferroptosis Sensitivity in Hepatocellular Carcinoma Cells by Lysosomal Ion Channels TPC2 and TRPML1 [PDF]

Antioxidants
Ferroptosis is an iron-dependent, lipid peroxidation–driven form of regulated cell death that has emerged as a therapeutic vulnerability in hepatocellular carcinoma (HCC), yet the contribution of lysosomes to this process remains incompletely understood.
Franz Geisslinger, Victoria Gell, Finja Witt, Dawid Jaślan, Christian Grimm, Andreas Koeberle, Karin Bartel   +6 more
doaj   +2 more sources

TPC2 rescues lysosomal storage in mucolipidosis type IV , Niemann–Pick type C1, and Batten disease

EMBO Molecular Medicine, 2022
Lysosomes are cell organelles that degrade macromolecules to recycle their components. If lysosomal degradative function is impaired, e.g., due to mutations in lysosomal enzymes or membrane proteins, lysosomal storage diseases (LSDs) can develop.
Einar Kleinhans Krogsaeter, Christian Grimm, Carla Abrahamian   +2 more
exaly   +2 more sources

Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC [PDF]

Frontiers in Immunology
IntroductionHepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates.
Lina Ouologuem, Anna Kübler, Sarah Ouologuem, Amar Hadzic, Amar Hadzic, Amar Hadzic, Jan B. Stöckl, Anna Chiara Siciliano, Stefania Forciniti, Salvatore Nigro, Helena Iuele, Valentina Onesto, Anny Nguyen, Dana Matzek, Carla Abrahamian, Carla Abrahamian, Carla Abrahamian, Christian Grimm, Christian Grimm, Christian Grimm, Bastian Popper, Giuseppe Gigli, Loretta L. del Mercato, Olivia M. Merkel, Olivia M. Merkel, Thomas Fröhlich, Sebastian Theurich, Sebastian Theurich, Sebastian Theurich, Karin Bartel, Karin Bartel, Karin Bartel   +31 more
doaj   +2 more sources