Results 1 to 10 of about 274 (113)

Targeting the two-pore channel 2 in cancer progression and metastasis [PDF]

Exploration of Targeted Anti-tumor Therapy, 2022
The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated.
Kathryn A. Skelding, Daniel L. Barry, Danielle Z. Theron, Lisa F. Lincz   +3 more
doaj   +3 more sources

P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2

Cell Reports, 2023
Summary: Upon proinflammatory challenges, endothelial cell surface presentation of the leukocyte receptor P-selectin, together with the stabilizing co-factor CD63, is needed for leukocyte capture and is mediated via demand-driven exocytosis from the ...
Jonas Goretzko, Inga Pauels, Nicole Heitzig, Katharina Thomas, Marina Kardell, Johannes Naß, Einar Kleinhans Krogsaeter, Sebastian Schloer, Barbara Spix, Anna Lívia Linard Matos, Charlotte Leser, Tristan Wegner, Frank Glorius, Franz Bracher, Volker Gerke, Jan Rossaint, Christian Grimm, Ursula Rescher   +17 more
doaj   +3 more sources

Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells. [PDF]

PLoS ONE, 2013
Nicotinic acid adenine dinucleotide phosphate (NAADP) is an endogenous Ca(2+) mobilizing nucleotide presented in various species. NAADP mobilizes Ca(2+) from acidic organelles through two pore channel 2 (TPC2) in many cell types and it has been ...
Zhe-Hao Zhang, Ying-Ying Lu, Jianbo Yue
doaj   +5 more sources

Two-pore channel-2 controls calmodulin-dependent STIM1 inactivation

Nature Communications
Lysosomal two-pore channels (TPC) trigger Ca2+ release from the endoplasmic reticulum (ER). The ensuing ER Ca2+ depletion activates STIM1-gated store-operated Ca2+ entry (SOCE) channels that sustain Ca2+ signals regulating fundamental cellular processes.
Subo Lee, Raphael Néré, Kyoung Sun Park, Vincent Jaquet, Nicolas Demaurex, Kyu-Sang Park   +5 more
doaj   +3 more sources

Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis

Scientific Reports, 2017
Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by electrophysiological evidence in a heterologous system, i.e. Arabidopsis vacuoles lacking
Irene Pafumi, Margherita Festa, Francesca Papacci, Laura Lagostena, Cristina Giunta, Vijay Gutla, Laura Cornara, Annarita Favia, Fioretta Palombi, Franco Gambale, Antonio Filippini, Armando Carpaneto   +11 more
doaj   +5 more sources

Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology [PDF]

Scientific Reports, 2016
AbstractLysosomal calcium (Ca2+) release mediated by NAADP triggers signalling cascades that regulate many cellular processes. The identification of two-pore channel 2 (TPC2) as the NAADP receptor advances our understanding of lysosomal Ca2+ signalling, yet the lysosome is not amenable to traditional patch-clamp electrophysiology.
Lee, CSK, Tong, BCK, Cheung, KH, Hung, HCH, Cheng, CWH   +4 more
openaire   +4 more sources

Identification of Two-pore Channel 2 as a Novel Regulator of Osteoclastogenesis [PDF]

Journal of Biological Chemistry, 2012
Osteoclast differentiation is one of the critical steps that control bone mass levels in osteoporosis, but the molecules involved in osteoclastogenesis are still incompletely understood. Here, we show that two-pore channel 2 (TPC2) is expressed in osteoclast precursor cells, and its knockdown (TPC2-KD) in these cells suppressed RANKL-induced key events
Takuya, Notomi, Yoichi, Ezura, Masaki, Noda   +2 more
openaire   +2 more sources

Two-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance

Communications Biology, 2022
YM201636 and PI-103 are potent inhibitors of human two-pore channel 2 that act through a channel pore entrance blockade mechanism.
Canwei Du, Xin Guan, Jiusheng Yan
doaj   +1 more source

Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies

Journal of Biomedical Science, 2022
Background Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain. Tauopathy can impair cognitive and motor functions and has been observed in Alzheimer’s disease (AD) and ...
Benjamin Chun-Kit Tong, Alexis Shiying Huang, Aston Jiaxi Wu, Ashok Iyaswamy, Olivia Ka-Yi Ho, Anna Hau-Yee Kong, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Chengfu Su, Jia Liu, Juxian Song, Min Li, King-Ho Cheung   +12 more
doaj   +1 more source

Two-pore channels for integrative Ca²⁺signaling [PDF]

Communicative & Integrative Biology, 2010
Two-pore channels (TPCs) are related to voltage-gated Ca(2+) and Na(+) channels. They most likely work as dimers with each of the two TPC protein subunits containing two pore-forming domains. Recent studies suggest that TPCs are expressed on the membranes of endosomes and lysosomes where they form receptors for nicotinic acid adenine dinucleotide ...
Zhu, M, Evans, A, Ma, J, Parrington, J, Galione, A   +4 more
openaire   +3 more sources