Results 11 to 20 of about 39,562,488 (191)

Loss of two-pore channel 2 function in melanoma-derived tumours reduces tumour growth in vivo but greatly increases tumour-related toxicity in the organism [PDF]

Cancer Cell International, 2023
Background Melanoma, a severe form of skin cancer, poses significant health risks due to its aggressive nature and potential for metastasis. The role of two-pore channel 2 (TPC2) in the development and progression of melanoma remains poorly understood ...
Ali Hanbashi, Moureq Alotaibi, Homood M. As Sobeai, Lama Binobaid, Khalid Alhazzani, Xuhui Jin, Faroq Kamli, Ali Alhoshani, John Parrington   +8 more
doaj   +2 more sources

Isolated pores dissected from human two-pore channel 2 are functional [PDF]

Scientific Reports, 2016
Abstract Multi-domain voltage-gated ion channels appear to have evolved through sequential rounds of intragenic duplication from a primordial one-domain precursor. Whereas modularity within one-domain symmetrical channels is established, little is known about the roles of individual regions within more complex ...
Penny, CJ, Rahman, T, Sula, A, Miles, AJ, Wallace, BA, Patel, S   +5 more
openaire   +5 more sources

Convergent activation of Ca ²⁺ permeability in two-pore channel 2 through distinct molecular routes [PDF]

Science Signaling, 2023
TPC2 is a pathophysiologically relevant lysosomal ion channel that is activated directly by the phosphoinositide PI(3,5)P 2 and indirectly by the calcium ion (Ca 2+ )–mobilizing molecule NAADP through accessory proteins that associate with the channel ...
Ryo Saito, Qianru Mu, Yu Yuan, Marcos Rubio-Alarcón, Maria Eznarriaga, Pingwei Zhao, Gihan Gunaratne, Sushil Kumar, Marco Keller, Franz Bracher, Christian Grimm, Eugen Brailoiu, Jonathan S. Marchant, Taufiq Rahman, Sandip Patel   +14 more
openaire   +4 more sources

The Two-Pore Channel 2 in Human Physiology and Diseases: Functional Characterisation and Pharmacology [PDF]

International Journal of Molecular Sciences
Two-pore channel 2 (TPC2) is a member of the endolysosomal ion channel family, playing critical roles in intracellular calcium signaling and endomembrane dynamics. This review provides an in-depth analysis of TPC2, covering its structural and functional properties, physiological roles, and involvement in human diseases.
Laura Lagostena, Velia Minicozzi, Martina Meucci, Antonella Gradogna, Stefan Milenkovic, Fioretta Palombi, Matteo Ceccarelli, Antonio Filippini, Armando Carpaneto   +8 more
openaire   +6 more sources

Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes and the endoplasmic reticulum [PDF]

Cell Reports
Summary: Lysosomes and the endoplasmic reticulum (ER) are Ca2+ stores mobilized by the second messengers NAADP and IP3, respectively. Here, we establish Ca2+ signals between the two sources as fundamental building blocks that couple local release to ...
Yu Yuan, Vikas Arige, Ryo Saito, Qianru Mu, Gabriela C. Brailoiu, Gustavo J.S. Pereira, Stephen R. Bolsover, Marco Keller, Franz Bracher, Christian Grimm, Eugen Brailoiu, Jonathan S. Marchant, David I. Yule, Sandip Patel   +13 more
doaj   +2 more sources

Activation of TREK‐1 and TREK‐2 Two‐Pore Domain Potassium Channels by the Kv4 Channel Modulator, NS5806

Pharmacology Research & Perspectives
NS5806 is a diaryl‐urea small molecule developed for the treatment of pain and neurological disorders. A potent activator of Kv4.3 potassium channels, it is widely used to study Kv4 channel physiology in excitable cells, including trigeminal neurons ...
E. L. Veale, P. M. Matthews, A. M. Rush, E. B. Stevens, A. Mathie   +4 more
doaj   +2 more sources

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2–dependent Ca ²⁺ signaling [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The formation of new blood vessels (neoangiogenesis) accompanies tissue regeneration and healing, but is also crucial for tumor growth, hence understanding how capillaries are stimulated to grow in response to local cues is essential for the much sought-after aim of controlling this process.
FAVIA, ANNARITA, M. Desideri, GAMBARA, Guido, A. D'Alessio, M. Ruas, ESPOSITO, BIANCA, D. Del Bufalo, J. Parrington, ZIPARO, Elio, PALOMBI, Fioretta, A. Galione, FILIPPINI, Antonio   +11 more
openaire   +4 more sources

Leukocyte adhesion is governed by endolysosomal two pore channel 2 (TPC2) [PDF]

, 2021
Abstract In response to pro-inflammatory challenges including pathogenic attack and tissue damage, the endothelial cell surface is rearranged to present leukocyte-engaging cell surface receptors. The initial contact needed for leukocyte tethering and rolling is mediated via adhesion demand-driven exocytosis of Weibel ...
Jonas Goretzko, Nicole Heitzig, Katharina Thomas, Einar Kleinhans Krogsaeter, Johannes Naß, Anna Lívia Linard Matos, Tristan Wegner, Sebastian Schloer, Volker Gerke, Jan Rossaint, Frank Glorius, Franz Bracher, Christian Grimm, Ursula Rescher   +13 more
openaire   +1 more source

Pharmacological inhibition of lysosomal two-pore channel 2 (TPC2) confers neuroprotection in stroke via autophagy regulation

Neurobiology of Disease, 2023
Lysosomal function and organellar Ca2+ homeostasis become dysfunctional in Stroke causing disturbances in autophagy, the major process for the degradation of abnormal protein aggregates and dysfunctional organelles.
Valentina Tedeschi, Antonio Vinciguerra, Maria Josè Sisalli, Giuseppe Pignataro, Agnese Secondo   +4 more
doaj   +1 more source

Simulations on Simple Models of Connexin Hemichannels Indicate That Ca²⁺ Blocking Is Not a Pure Electrostatic Effect

Membranes, 2021
Connexin hemichannels allow the unspecific but regulated interchange of molecules from ions to second messenger and ATP, between the eukariotic cell and its extracellular space.
Felipe Villanelo, Jorge Carrasco, Joaquin Jensen-Flores, Jose Antonio Garate, Tomas Perez-Acle   +4 more
doaj   +1 more source