PLoS ONE, 2023 A member of THIK (two pore domain halothane-inhibited K+) channels, THIK-1, was reported as a target of Gi/o-coupled receptors (Gi/o-Rs) in neurons and microglia.
Michihiro Tateyama, Yoshihiro Kubo
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Thermosensitivity of the two‐pore domain K+ channels TREK‐2 and TRAAK [PDF]
The Journal of Physiology, 2005 TREK‐1, TREK‐2 and TRAAK are members of the two‐pore domain K+ (K2P) channel family and are activated by membrane stretch and free fatty acids. TREK‐1 has been shown to be sensitive to temperature in expression systems. We studied the temperature‐sensitivity of TREK‐2 and TRAAK in COS‐7 cells and in neuronal cells.
Dawon, Kang +2 more
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Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
eLife, 2020 Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (Calcraft et al., 2009; Guo et al., 2017; Jha et al., 2014; Ruas et al.,
Susanne Gerndt +22 more
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Two-Pore Domain K + Channels [PDF]
Hypertension, 2011 See related article, pp 672–678 The dynamic regulation of blood pressure relies on the ability of small arteries and arterioles to finely adjust their diameters to maintain peripheral vascular resistance and cardiovascular homeostasis. At the level of the vascular smooth muscle cell (VSMC), contraction is mediated by elevations in cytosolic Ca2 ...
Asif R, Pathan, Nancy J, Rusch
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The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage : gating at the cytoplasmic mouth [PDF]
, 2009 Although the tandem pore potassium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of extracellular pH, it is currently unknown whether the channel also shows gating at its inner, cytoplasmic mouth through ...
Feng, J. F. +23 more
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The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1 : contributions of the pore domains [PDF]
, 2007 We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1.
Sutcliffe, M. J. +14 more
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Impedance analysis and single ion channel recordings on pore-suspending lipid bilayers based on highly ordered pore arrays [PDF]
, 2006 Ion channels are one of the main drug targets and are in the focus of various membrane biosensor applications and drug screening assays. The aim of this thesis was to develop and characterize a novel membrane system suspending highly ordered porous ...
Römer, Winfried
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High susceptibility to fatty liver disease in two-pore channel 2-deficient mice [PDF]
Nature Communications, 2014 Endolysosomal organelles play a key role in trafficking, breakdown and receptor-mediated recycling of different macromolecules such as low-density lipoprotein (LDL)-cholesterol, epithelial growth factor (EGF) or transferrin. Here we examine the role of two-pore channel (TPC) 2, an endolysosomal cation channel, in these processes.
Grimm, Christian +25 more
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Membranes, 2021 The behavior of fluids under nano-confinement varies from that in bulk due to an interplay of several factors including pore connectivity. In this work, we use molecular dynamics simulations to study the behavior of two fluids—ethane and CO2 confined in ...
Mohammed Musthafa Kummali +2 more
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Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes. [PDF]
, 2012 Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein.
Felix Schmidt +11 more
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