Results 41 to 50 of about 39,562,488 (191)
Two-Pore Channels Regulate Inter-Organellar Ca2+ Homeostasis in Immune Cells
Cells, 2022 Two-pore channels (TPCs) are ligand-gated cation-selective ion channels that are preserved in plant and animal cells. In the latter, TPCs are located in membranes of acidic organelles, such as endosomes, lysosomes, and endolysosomes. Here, we focus on the function of these unique ion channels in mast cells, which are leukocytes that mature from myeloid
Philip Steiner +4 more
openaire +3 more sources
Molecular mechanisms of the coupling of gating to voltage sensing in transmembrane proteins [PDF]
, 2014 Voltage gated potassium ion (Kv) channels regulate action potentials of the nervous system by responding to changes in transmembrane voltage, enabling K+ transport across the membrane to restore cells to their resting potential.
Starek, Greg
core +1 more source
PLoS Computational Biology, 2020 This work reports a dynamical Markov state model of CLC-2 "fast" (pore) gating, based on 600 microseconds of molecular dynamics (MD) simulation. In the starting conformation of our CLC-2 model, both outer and inner channel gates are closed.
Keri A McKiernan +3 more
doaj +1 more source
Contact, 2023 We have previously shown that in the developing trunk of zebrafish embryos, two-pore channel type 2 (TPC2)-mediated Ca 2+ release from endolysosomes plays a role in the formation of the skeletal slow muscle.
Keira L. Rice +4 more
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Energy Exploration & Exploitation, 2018 The process of water–gas displacement in water–drive gas reservoirs has been always an important research topic. However, knowledge about the flow patterns of water–gas flow under different conditions is insufficient at present.
Weiyong Lu, Bingxiang Huang
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Frontiers in Cellular Neuroscience, 2016 In response to diverse stimuli, two-pore-domain potassium channel TREK-2 regulates cellular excitability, and hence plays a key role in mediating neuropathic pain, mood disorders and ischemia through.
Ren-Gong eZhuo +7 more
doaj +1 more source
The Two‐pore channel 2 (TPC2) mediates autophagy in skeletal muscles
The FASEB Journal, 2013 Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+‐mobilizing messenger that in many cells releases Ca2+ from the endolysosomal system. Recent studies have shown that NAADP‐induced Ca2+ mobilization is mediated by the two‐pore channels (TPCs).
pei‐hui Lin +6 more
openaire +1 more source
A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]
, 2013 TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars +14 more
core +2 more sources
Extracellular blockade of K(+) channels by TEA : results from molecular dynamics simulations of the KcsA channel [PDF]
, 2001 TEA is a classical blocker of K(+) channels. From mutagenesis studies, it has been shown that external blockade by TEA is strongly dependent upon the presence of aromatic residue at Shaker position 449 which is located near the extracellular entrance to ...
Simon Bernèche +5 more
core +1 more source
Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator. [PDF]
PLoS ONE, 2018 We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we identified a hydroxycoumarin-related compound, ostruthin, as an activator of this channel ...
Ancy Joseph +3 more
doaj +1 more source