Structural insights into Clostridium perfringens delta toxin pore formation [PDF]
, 2013 Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
Claire E Naylor +37 more
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Molecules, 2021 The permeability transition (PT) is an increased permeation of the inner mitochondrial membrane due to the opening of the PT pore (PTP), a Ca2+-activated high conductance channel involved in Ca2+ homeostasis and cell death.
Andrea Carrer +3 more
doaj +1 more source
Lysosomal Two-pore Channel Subtype 2 (TPC2) Regulates Skeletal Muscle Autophagic Signaling [PDF]
Journal of Biological Chemistry, 2015 Postnatal skeletal muscle mass is regulated by the balance between anabolic protein synthesis and catabolic protein degradation, and muscle atrophy occurs when protein homeostasis is disrupted. Autophagy has emerged as critical in clearing dysfunctional organelles and thus in regulating protein turnover. Here we show that endolysosomal two-pore channel
Lin, Pei-Hui +12 more
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TASK-2 Expression Levels are Increased in Mouse Cryopreserved Ovar
Journal of Animal Reproduction and Biotechnology, 2015 Cryopreservation affects osmotic tolerance and intracellular ion concentration through changes in expression levels of water and ion channels. Control of these changes is important for cell survival after cryopreservation.
Dawon Kang +4 more
doaj +1 more source
Gating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter. [PDF]
PLoS ONE, 2011 K(+) channels share common selectivity characteristics but exhibit a wide diversity in how they are gated open. Leak K(2P) K(+) channels TASK-2, TALK-1 and TALK-2 are gated open by extracellular alkalinization.
Leandro Zúñiga +6 more
doaj +1 more source
Characterization of two-pore channel 2 by nuclear membrane electrophysiology [PDF]
, 2017 published_or_final_version ; Biomedical Sciences ; Doctoral ; Doctor of ...
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Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH [PDF]
Journal of Biological Chemistry, 2013 Autophagy is an evolutionarily conserved lysosomal degradation pathway, yet the underlying mechanisms remain poorly understood. Nicotinic acid adenine dinucleotide phosphate (NAADP), one of the most potent Ca(2+) mobilizing messengers, elicits Ca(2+) release from lysosomes via the two pore channel 2 (TPC2) in many cell types.
Yue, J +5 more
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A general theory of polymer ejection tested in a quasi two-dimensional space
Scientific Reports, 2021 A general ejection theory of polymer is developed in a two- and three-dimensional space. A polymer is confined initially in a cavity and ejects spontaneously to the outer space through a nanopore channel without the help of any external stimulus.
Pai-Yi Hsiao, Wei-Yei Chen
doaj +1 more source
Identification of a key residue for Oligomerisation and pore-formation of Clostridium perfringens NetB [PDF]
, 2014 Necrotic enteritis toxin B (NetB) is a β-pore-forming toxin produced by Clostridium perfringens and has been identified as a key virulence factor in the pathogenesis of avian necrotic enteritis, a disease causing significant economic damage to the ...
Richard W. Titball +24 more
core +1 more source
Two-pore channels and NAADP-dependent calcium signalling [PDF]
, 2010 Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca²⁺ mobilising messenger in mammalian and non-mammalian cells. Studies on a variety of cell types suggest that NAADP evokes Ca²⁺ release from a lysosome-related store and via activation ...
Calcraft, Peter James
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