Results 1 to 10 of about 158,743 (267)
Frontiers in Immunology, 2022 The P2X7 receptor is a critical purinergic receptor in immune cells. Its activation was associated with cathepsin release into macrophage cytosol, suggesting its involvement in lysosomal membrane permeabilization (LMP) and leakage.
Stephanie Alexia Cristina Silva Santos +10 more
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Cuproproteins of Hepatocyte Lysosomes in Normal and Fatty Liver [PDF]
, 1993 1993-03The pathophysiological significance of cuproproteins in hepatocyte lysosomes was studied in 7 patients with structurally normal livers and 13 patients with fatty livers by energy-dispersion X-ray microanalysis.
SAKAMOTO, NOBUO +4 more
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“LRRK2: Autophagy and Lysosomal Activity”
Frontiers in Neuroscience, 2020 It has been 15 years since the Leucine-rich repeat kinase 2 (LRRK2) gene was identified as the most common genetic cause for Parkinson’s disease (PD). The two most common mutations are the LRRK2-G2019S, located in the kinase domain, and the LRRK2-R1441C,
Marta Madureira +3 more
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Lysosomes in acute myeloid leukemia: potential therapeutic targets? [PDF]
, 2021 Lysosomes, since their discovery, have been primarily known for degrading cellular macromolecules. However, in recent studies, they have begun to emerge as crucial regulators of cell homeostasis.
Muller, Sylviane +4 more
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Granular Cell Transformation in Plexiform Ameloblastoma: Case Report and Literature Review [PDF]
International Journal of Scientific Research in Dental and Medical SciencesAmeloblastoma is the most common odontogenic tumor, primarily occurring in the posterior mandible. It is a slow-growing yet locally invasive epithelial tumor that generally follows a benign course.
Aravindan S +5 more
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Signals involved in protein intracellular sorting [PDF]
, 2005 “…Confusion appears to occur just after the articulation of a major conceptual advance that served to greatly clarify a problem of exceptional importance.”- Ira Mellman, 1996.
Nair, Prashant
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LYSOSOME-DEPENDENT CELL DEATH DEFINES SPECIFIC ENDOTHELIAL TOXICITY OF CALCIUM PHOSPHATE BIONS
Сибирский научный медицинский журнал, 2019 Aim of the study was to identify the mechanism of specific endothelial toxicity related to calcium phosphate bions (CPB). Material and methods. CPB and magnesium phosphate bions (MPB) were artificially synthesised through supersaturation of culture ...
D. K. Shishkova +7 more
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A Ratiometric Fluorescent Probe for Hypochlorite and Lipid Droplets to Monitor Oxidative Stress
Biosensors, 2023 Mitochondria are valuable subcellular organelles and play crucial roles in redox signaling in living cells. Substantial evidence proved that mitochondria are one of the critical sources of reactive oxygen species (ROS), and overproduction of ROS ...
Mousumi Baruah +4 more
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Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes
Cell Reports, 2018 Variants in the phospholipase D3 (PLD3) gene have genetically been linked to late-onset Alzheimer's disease. We present a detailed biochemical analysis of PLD3 and reveal its endogenous localization in endosomes and lysosomes. PLD3 reaches lysosomes as a
Adriana Carolina Gonzalez +6 more
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mSphere, 2018 Trypanosoma cruzi, the etiologic agent of Chagas disease, undergoes drastic metabolic changes when it transits between a vector and mammalian hosts. Amino acid catabolism leads to the production of ammonium (NH4+), which needs to be detoxified.
Teresa Cruz-Bustos +3 more
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