Results 1 to 10 of about 168,690 (311)
Branching Off: New Insight Into Lysosomes as Tubular Organelles [PDF]
Frontiers in Cell and Developmental Biology, 2022 Lysosomes are acidic, membrane-bound organelles that play essential roles in cellular quality control, metabolism, and signaling. The lysosomes of a cell are commonly depicted as vesicular organelles.
K. Adam Bohnert, Alyssa E. Johnson
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Super‐resolution analyzing spatial organization of lysosomes with an organic fluorescent probe
Exploration, 2022 Lysosomes are multifunctional organelles involved in macromolecule degradation, nutrient sensing, and autophagy. Live imaging has revealed lysosome subpopulations with dynamics and characteristic cellular localization.
Taosheng Huang, Lei Wang, Guanqun Han
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eLifeThe formation of large endolysosomal structures in unfertilized eggs ensures that lysosomes remain dormant before fertilization, and then shift into clean-up mode after the egg-to-embryo transition.
Deepak Adhikari, John Carroll
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Data in Brief, 2023 Automated detection of cell nuclei in fluorescence microscopy images is a key task in bioimage analysis. It is essential for most types of microscopy-based high-throughput drug and genomic screening and is often required in smaller scale experiments as ...
Malou Arvidsson +2 more
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Synaptic Function and Dysfunction in Lysosomal Storage Diseases
Frontiers in Cellular Neuroscience, 2021 Lysosomal storage diseases (LSDs) with neurological involvement are inherited genetic diseases of the metabolism characterized by lysosomal dysfunction and the accumulation of undegraded substrates altering glial and neuronal function.
Rima Rebiai +5 more
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Unusual Presentation of Atypical Infantile Pompe Disease in the Newborn Period with Left Ventricular Hypertrophy [PDF]
Journal of Clinical and Diagnostic Research, 2017 Pompe disease, also known as glycogen storage disease Type II, is a lysosomal storage disorder caused by α-glucosidase deficiency. In general, the clinical spectrum varies with respect to the age of onset, residual enzyme activity and organ involvement.
Sanjay Kumar, Amit Kumar
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Frontiers in Cell and Developmental Biology, 2021 Neurons are highly complex polarized cells, displaying an extraordinary degree of spatial compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local protein synthesis is utilized to continually modify the synaptic proteome,
Dipen Rajgor +2 more
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Lysosome-endosome fusion and lysosome biogenesis [PDF]
Journal of Cell Science, 2000 ABSTRACT Recent data both from cell-free experiments and from cultured cells have shown that lysosomes can fuse directly with late endosomes to form a hybrid organelle. This has a led to a hypothesis that dense core lysosomes are in essence storage granules for acid hydrolases and that, when the former fuse with late endosomes, a ...
J P, Luzio +5 more
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Lysosomes and lysosome‐related organelles in immune responses
FEBS Open Bio, 2022 The catabolic, degradative capacity of the endo‐lysosome system is put to good use in mammalian immune responses as is their recently established status as signaling platforms.
Colin Watts
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Frontiers in Immunology, 2022 The P2X7 receptor is a critical purinergic receptor in immune cells. Its activation was associated with cathepsin release into macrophage cytosol, suggesting its involvement in lysosomal membrane permeabilization (LMP) and leakage.
Stephanie Alexia Cristina Silva Santos +10 more
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