Results 21 to 30 of about 168,690 (311)
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes
Cell Reports, 2018 Variants in the phospholipase D3 (PLD3) gene have genetically been linked to late-onset Alzheimer's disease. We present a detailed biochemical analysis of PLD3 and reveal its endogenous localization in endosomes and lysosomes. PLD3 reaches lysosomes as a
Adriana Carolina Gonzalez +6 more
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Signals involved in protein intracellular sorting [PDF]
, 2005 “…Confusion appears to occur just after the articulation of a major conceptual advance that served to greatly clarify a problem of exceptional importance.”- Ira Mellman, 1996.
Nair, Prashant
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mSphere, 2018 Trypanosoma cruzi, the etiologic agent of Chagas disease, undergoes drastic metabolic changes when it transits between a vector and mammalian hosts. Amino acid catabolism leads to the production of ammonium (NH4+), which needs to be detoxified.
Teresa Cruz-Bustos +3 more
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mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival [PDF]
, 2015 Funding provided by: Wellcome Trust Technology Platform 097945/B/11/Z, MRC Next Generation Optical Microscopy MR/K015869/1, Medical Research Council, Division of Signal Transduction Therapy Unit (AstraZeneca, Boehringer‐Ingelheim, GlaxoSmithKline, Merck ...
Michael J Munson +12 more
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, 2023 While lysosomes have popularly been tokened the “disposal system of the cell,” it is being uncovered that they play an important role in more cellular processes, like apoptosis and assisting the immune system.
Gheen, Caroline
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Targeting the sAC-Dependent cAMP Pool to Prevent SARS-Cov-2 Infection
Cells, 2020 An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption ...
Muhammad Aslam, Yury Ladilov
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Lysosomes in acute myeloid leukemia: potential therapeutic targets? [PDF]
, 2021 Lysosomes, since their discovery, have been primarily known for degrading cellular macromolecules. However, in recent studies, they have begun to emerge as crucial regulators of cell homeostasis.
Muller, Sylviane +4 more
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IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2006 The lysosomal compartment is the place for cellular degradation of endocytosed and autophagocytosed material and a center for normal turnover of organelles as well as most long-lived proteins. Lysosomes were long considered stable structures that broke and released their many hydrolytic enzymes only following necrotic cell death.
A, Terman +3 more
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, 2018 Movies of fluorescently labelled lysosomes acquired in living ...
Francesco Cardarelli (249459) +5 more
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Data in BriefMany forms of bioimage analysis involve the detection of objects and their outlines. In the context of microscopy-based high-throughput drug and genomic screening and even in smaller scale microscopy experiments, the objects that most often need to be ...
Salma Kazemi Rashed +3 more
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