Results 21 to 30 of about 228,048 (263)
Distribution of chromaffin secretory vesicles, acetylcholinesterase, and lysosomal enzymes in sucrose and percoll gradients [PDF]
, 1984 Crude chromaffin secretory vesicles, obtained by differential centrifugation, were further purified on isotonic (Percoll) gradients. The chromaffin vesicle fractions recovered from the gradients contain acetylcholinesterase as well as lysosomal enzymes ...
Bowers +31 more
core +1 more source
LYSOSOME-DEPENDENT CELL DEATH DEFINES SPECIFIC ENDOTHELIAL TOXICITY OF CALCIUM PHOSPHATE BIONS
Сибирский научный медицинский журнал, 2019 Aim of the study was to identify the mechanism of specific endothelial toxicity related to calcium phosphate bions (CPB). Material and methods. CPB and magnesium phosphate bions (MPB) were artificially synthesised through supersaturation of culture ...
D. K. Shishkova +7 more
doaj +1 more source
A Ratiometric Fluorescent Probe for Hypochlorite and Lipid Droplets to Monitor Oxidative Stress
Biosensors, 2023 Mitochondria are valuable subcellular organelles and play crucial roles in redox signaling in living cells. Substantial evidence proved that mitochondria are one of the critical sources of reactive oxygen species (ROS), and overproduction of ROS ...
Mousumi Baruah +4 more
doaj +1 more source
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes
Cell Reports, 2018 Variants in the phospholipase D3 (PLD3) gene have genetically been linked to late-onset Alzheimer's disease. We present a detailed biochemical analysis of PLD3 and reveal its endogenous localization in endosomes and lysosomes. PLD3 reaches lysosomes as a
Adriana Carolina Gonzalez +6 more
doaj +1 more source
mSphere, 2018 Trypanosoma cruzi, the etiologic agent of Chagas disease, undergoes drastic metabolic changes when it transits between a vector and mammalian hosts. Amino acid catabolism leads to the production of ammonium (NH4+), which needs to be detoxified.
Teresa Cruz-Bustos +3 more
doaj +1 more source
A workflow for the automatic segmentation of organelles in electron microscopy image stacks. [PDF]
, 2014 Electron microscopy (EM) facilitates analysis of the form, distribution, and functional status of key organelle systems in various pathological processes, including those associated with neurodegenerative disease. Such EM data often provide important new
Bushong, Eric A +6 more
core +2 more sources
Data in BriefMany forms of bioimage analysis involve the detection of objects and their outlines. In the context of microscopy-based high-throughput drug and genomic screening and even in smaller scale microscopy experiments, the objects that most often need to be ...
Salma Kazemi Rashed +3 more
doaj +1 more source
Targeting the sAC-Dependent cAMP Pool to Prevent SARS-Cov-2 Infection
Cells, 2020 An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption ...
Muhammad Aslam, Yury Ladilov
doaj +1 more source
eLifeThe formation of large endolysosomal structures in unfertilized eggs ensures that lysosomes remain dormant before fertilization, and then shift into clean-up mode after the egg-to-embryo transition.
Deepak Adhikari, John Carroll
doaj +1 more source
Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2019 The results of a study on the spawning-period activity of lysosomal proteases (cathepsins B and D) in the organs (muscles, liver, gills, gonads) of threespine stickleback (Gasterosteus aculeatus L.) from hydrologically and ecologically different White ...
Marina Krupnova +2 more
doaj +1 more source