Results 21 to 30 of about 140,536 (267)
Data in BriefMany forms of bioimage analysis involve the detection of objects and their outlines. In the context of microscopy-based high-throughput drug and genomic screening and even in smaller scale microscopy experiments, the objects that most often need to be ...
Salma Kazemi Rashed +3 more
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Journal of Lipid Research, 2003 It has been reported that an accumulation of cholesterol within late endosomes/lysosomes in Niemann-Pick type C (NPC) fibroblasts and U18666A-treated cells causes impairment of retrograde trafficking of the cation-independent mannose 6-phosphate/IGF-II ...
Atsushi Umeda +5 more
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In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons
Biosensors, 2022 Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies against Aβ capture
Alec K. McKendell +5 more
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Neuroscience Letters, 2019 Lysosomes support diverse cellular functions by acting as sites of macromolecule degradation and nutrient recycling. The degradative abilities of lysosomes are conferred by a lumen that is characterized by an acidic pH and which contains numerous hydrolases that support the breakdown of major cellular macromolecules to yield cellular building blocks ...
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Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity[S]
Journal of Lipid Research, 2015 Autophagy is a catabolic process involved in maintaining energy and organelle homeostasis. The relationship between obesity and the regulation of autophagy is cell type specific.
Bharat Jaishy +9 more
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Manifestations of Age on Autophagy, Mitophagy and Lysosomes in Skeletal Muscle
Cells, 2021 Sarcopenia is the loss of both muscle mass and function with age. Although the molecular underpinnings of sarcopenia are not fully understood, numerous pathways are implicated, including autophagy, in which defective cargo is selectively identified and ...
Matthew Triolo, David A. Hood
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Annual Review of Physiology, 2015 Lysosomes are acidic compartments filled with more than 60 different types of hydrolases. They mediate the degradation of extracellular particles from endocytosis and of intracellular components from autophagy. The digested products are transported out of the lysosome via specific catabolite exporters or via vesicular membrane trafficking.
Haoxing, Xu, Dejian, Ren
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Deciphering tuberculosis: lysosome-centric insights into pathogenesis and therapies
Frontiers in Cellular and Infection MicrobiologyTuberculosis is a widely spread disease caused by Mycobacterium tuberculosis (Mtb). The pathogenicity of the pathogen is closely associated with the immune defense mechanisms of the host cells. As key cellular degradation and metabolic centers, lysosomes
Cui Bao +10 more
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
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Organelle Cooperation in Stem Cell Fate: Lysosomes as Emerging Regulators of Cell Identity
Frontiers in Cell and Developmental Biology, 2020 Regulation of stem cell fate is best understood at the level of gene and protein regulatory networks, though it is now clear that multiple cellular organelles also have critical impacts.
Lisa M. Julian +4 more
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