Results 21 to 30 of about 171,488 (262)

Targeting the sAC-Dependent cAMP Pool to Prevent SARS-Cov-2 Infection

Cells, 2020
An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption ...
Muhammad Aslam, Yury Ladilov
doaj   +1 more source

Lysosomes

, 2018
Movies of fluorescently labelled lysosomes acquired in living ...
Francesco Cardarelli (249459), William Durso (4754013), Francesca D'Autilia (655066), Luca Digiacomo (1518349), Giulio Caracciolo (1518355), Gianmarco Ferri (281845)   +5 more
core   +1 more source

An annotated high-content fluorescence microscopy dataset with EGFP-Galectin-3-stained cells and manually labelled outlineszenodo

Data in Brief
Many forms of bioimage analysis involve the detection of objects and their outlines. In the context of microscopy-based high-throughput drug and genomic screening and even in smaller scale microscopy experiments, the objects that most often need to be ...
Salma Kazemi Rashed, Malou Arvidsson, Rafsan Ahmed, Sonja Aits   +3 more
doaj   +1 more source

secretory lysosomes

, 2007
Chediak-Higashi syndrome (CHS) is characterized at the cellular level by a defect in the ability of cells to secrete lysosomes. However, the precise step affected in the secretion process is unclear.
Cosson, Pierre, Steve J. Charette, Pierre Cosson, Charette, Steve, Cosson P, Charette SJ   +5 more
core   +1 more source

Switching on lysosomes

eLife
The formation of large endolysosomal structures in unfertilized eggs ensures that lysosomes remain dormant before fertilization, and then shift into clean-up mode after the egg-to-embryo transition.
Deepak Adhikari, John Carroll
doaj   +1 more source

Lipids and lysosomes

, 2012
Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis ...
Arnould, Thierry, Hamer, Isabelle, Jadot, Michel, Van Beersel, Guillaume   +3 more
core   +1 more source

Distribution and trafficking of MPR300 is normal in cells with cholesterol accumulated in late endocytic compartments

Journal of Lipid Research, 2003
It has been reported that an accumulation of cholesterol within late endosomes/lysosomes in Niemann-Pick type C (NPC) fibroblasts and U18666A-treated cells causes impairment of retrograde trafficking of the cation-independent mannose 6-phosphate/IGF-II ...
Atsushi Umeda, Hideaki Fujita, Toshio Kuronita, Kaori Hirosako, Masaru Himeno, Yoshitaka Tanaka   +5 more
doaj   +1 more source

In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons

Biosensors, 2022
Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies against Aβ capture
Alec K. McKendell, Mei C. Q. Houser, Shane P. C. Mitchell, Michael S. Wolfe, Oksana Berezovska, Masato Maesako   +5 more
doaj   +1 more source

Deciphering tuberculosis: lysosome-centric insights into pathogenesis and therapies

Frontiers in Cellular and Infection Microbiology
Tuberculosis is a widely spread disease caused by Mycobacterium tuberculosis (Mtb). The pathogenicity of the pathogen is closely associated with the immune defense mechanisms of the host cells. As key cellular degradation and metabolic centers, lysosomes
Cui Bao, Cui Bao, Yuanyuan Zhang, Yuanyuan Zhang, Jiao Feng, Jiao Feng, Xiuwen Hong, Xiuwen Hong, Nan Gao, Nan Gao, Ganzhu Feng   +10 more
doaj   +1 more source

Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity[S]

Journal of Lipid Research, 2015
Autophagy is a catabolic process involved in maintaining energy and organelle homeostasis. The relationship between obesity and the regulation of autophagy is cell type specific.
Bharat Jaishy, Quanjiang Zhang, Heaseung S. Chung, Christian Riehle, Jamie Soto, Stephen Jenkins, Patrick Abel, L.Ashley Cowart, Jennifer E. Van Eyk, E.Dale Abel   +9 more
doaj   +1 more source