Results 31 to 40 of about 140,536 (267)

Increase of Claudin-5, ICAM-1 and eNOS expressions in human brain endothelial cells by ammonium chloride

Türk Biyokimya Dergisi, 2023
Lysosomal dysfunction could lead to a failure in the degradation process of waste materials, especially for the elimination of aggregated, misfolded and senescence proteins or organelles.
Jufri Nurul Farhana, Salyam Tharshini, Ibrahim Farah Wahida, Yoganathan Dharrshine, Hamid Asmah, Abdul Latif Mazlyzam, Mohd Saleh Siti Nurdiyana, Juhari Nor Atikah Safirah   +7 more
doaj   +1 more source

Lysosomal labilization [PDF]

IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2006
The lysosomal compartment is the place for cellular degradation of endocytosed and autophagocytosed material and a center for normal turnover of organelles as well as most long-lived proteins. Lysosomes were long considered stable structures that broke and released their many hydrolytic enzymes only following necrotic cell death.
A, Terman, T, Kurz, B, Gustafsson, U T, Brunk   +3 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Construction of Triphenylamine-Based Aggregation-Induced Emission Luminogens for Lysosomes Imaging and Its Application in the Photodynamic Therapy of Cancer Cells

Molecules
Lysosomes are important acidic subcellular organelles whose dysfunction can lead to some related diseases. The development of new lysosome-imaging-guided AIEgens for the photodynamic therapy of cancer cells is important.
Zhanguo Sun, Bin Liu, Huijun Liu
doaj   +1 more source

Cellular Bioreactivity of Micro- and Nano-Plastic Particles in Oysters

Frontiers in Marine Science, 2018
The global usage of plastics has increased dramatically over the last several decades. Polystyrene (PS) is the fourth most common plastic material produced annually due to its many versatile applications.
Tamara R. Gaspar, Richard J. Chi, Matthew W. Parrow, Amy H. Ringwood   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

PLEKHM1 Overexpression Impairs Autophagy and Exacerbates Neurodegeneration in rAAV-α-Synuclein Mice

Cells
The aggregation of α-synuclein (αSyn) is a central feature of Parkinson’s disease (PD) and other synucleinopathies. The efficient clearance of αSyn depends largely on the autophagy–lysosomal pathway.
Lennart Höfs, David Geißler-Lösch, Björn H. Falkenburger   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Deciphering α-L-Fucosidase Activity Contribution in Human and Mouse: Tissue α-L-Fucosidase FUCA1 Meets Plasma α-L-Fucosidase FUCA2

Cells
Fucose-containing glycoproteins and glycolipids broadly occur in humans as well as in many other species and are essential for a wide range of physiological processes, such as cell adhesion, fertilization, and tumor development.
Hannah Bäumges, Svenja Jelinek, Heike Lange, Sandra Markmann, Emanuela Capriotti, Jan Anwar Häusser, Mai-Britt Ilse, Thomas Braulke, Torben Lübke   +8 more
doaj   +1 more source

Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease

Cells, 2022
CLN5 disease (MIM: 256731) represents a rare late-infantile form of neuronal ceroid lipofuscinosis (NCL), caused by mutations in the CLN5 gene that encodes the CLN5 protein (CLN5p), whose physiological roles stay unanswered.
Stefano Doccini, Maria Marchese, Federica Morani, Nicola Gammaldi, Serena Mero, Francesco Pezzini, Rabah Soliymani, Melissa Santi, Giovanni Signore, Asahi Ogi, Silvia Rocchiccioli, Katja M. Kanninen, Alessandro Simonati, Maciej M. Lalowski, Filippo M. Santorelli   +14 more
doaj   +1 more source