Results 31 to 40 of about 158,743 (267)
Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity[S]
Journal of Lipid Research, 2015 Autophagy is a catabolic process involved in maintaining energy and organelle homeostasis. The relationship between obesity and the regulation of autophagy is cell type specific.
Bharat Jaishy +9 more
doaj +1 more source
Manifestations of Age on Autophagy, Mitophagy and Lysosomes in Skeletal Muscle
Cells, 2021 Sarcopenia is the loss of both muscle mass and function with age. Although the molecular underpinnings of sarcopenia are not fully understood, numerous pathways are implicated, including autophagy, in which defective cargo is selectively identified and ...
Matthew Triolo, David A. Hood
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
, 2012 Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis ...
Arnould, Thierry +3 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
, 2023 While lysosomes have popularly been tokened the “disposal system of the cell,” it is being uncovered that they play an important role in more cellular processes, like apoptosis and assisting the immune system.
Gheen, Caroline
core
MoleculesLysosomes are important acidic subcellular organelles whose dysfunction can lead to some related diseases. The development of new lysosome-imaging-guided AIEgens for the photodynamic therapy of cancer cells is important.
Zhanguo Sun, Bin Liu, Huijun Liu
doaj +1 more source
Organelle Cooperation in Stem Cell Fate: Lysosomes as Emerging Regulators of Cell Identity
Frontiers in Cell and Developmental Biology, 2020 Regulation of stem cell fate is best understood at the level of gene and protein regulatory networks, though it is now clear that multiple cellular organelles also have critical impacts.
Lisa M. Julian +4 more
doaj +1 more source
Türk Biyokimya Dergisi, 2023 Lysosomal dysfunction could lead to a failure in the degradation process of waste materials, especially for the elimination of aggregated, misfolded and senescence proteins or organelles.
Jufri Nurul Farhana +7 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source