Results 31 to 40 of about 168,690 (311)
Journal of Lipid Research, 2003 It has been reported that an accumulation of cholesterol within late endosomes/lysosomes in Niemann-Pick type C (NPC) fibroblasts and U18666A-treated cells causes impairment of retrograde trafficking of the cation-independent mannose 6-phosphate/IGF-II ...
Atsushi Umeda +5 more
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In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons
Biosensors, 2022 Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies against Aβ capture
Alec K. McKendell +5 more
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Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity[S]
Journal of Lipid Research, 2015 Autophagy is a catabolic process involved in maintaining energy and organelle homeostasis. The relationship between obesity and the regulation of autophagy is cell type specific.
Bharat Jaishy +9 more
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Manifestations of Age on Autophagy, Mitophagy and Lysosomes in Skeletal Muscle
Cells, 2021 Sarcopenia is the loss of both muscle mass and function with age. Although the molecular underpinnings of sarcopenia are not fully understood, numerous pathways are implicated, including autophagy, in which defective cargo is selectively identified and ...
Matthew Triolo, David A. Hood
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Degradation of Melanosomes by Lysosomes [PDF]
, 1971 The degradation of melanosomes by the lysosomes of the mouse liver was studied in vitro. Mice with melanoma received intraperitoneal injections of a 14C-amino acid mixture and 14C-dopa separately.
N. Ohtaki +3 more
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Deciphering tuberculosis: lysosome-centric insights into pathogenesis and therapies
Frontiers in Cellular and Infection MicrobiologyTuberculosis is a widely spread disease caused by Mycobacterium tuberculosis (Mtb). The pathogenicity of the pathogen is closely associated with the immune defense mechanisms of the host cells. As key cellular degradation and metabolic centers, lysosomes
Cui Bao +10 more
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Organelle Cooperation in Stem Cell Fate: Lysosomes as Emerging Regulators of Cell Identity
Frontiers in Cell and Developmental Biology, 2020 Regulation of stem cell fate is best understood at the level of gene and protein regulatory networks, though it is now clear that multiple cellular organelles also have critical impacts.
Lisa M. Julian +4 more
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Türk Biyokimya Dergisi, 2023 Lysosomal dysfunction could lead to a failure in the degradation process of waste materials, especially for the elimination of aggregated, misfolded and senescence proteins or organelles.
Jufri Nurul Farhana +7 more
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, 2007 Chediak-Higashi syndrome (CHS) is characterized at the cellular level by a defect in the ability of cells to secrete lysosomes. However, the precise step affected in the secretion process is unclear.
Cosson, Pierre +3 more
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Are Melanosome Complexes Lysosomes? [PDF]
, 1972 The formation of secondary lysosomes was induced in keratinocytes of guinea pig skin. Lysosomes labeled by an electron microscopic tracer (Thorotrast) were observed to fuse with and spill their contents into melanosome complexes and membrane bound single
Hönigsmann, Herbert, Wolff, Klaus
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