Results 31 to 40 of about 228,048 (263)
Glutamate induces autophagy via the two-pore channels in neural cells [PDF]
, 2016 NAADP (nicotinic acid adenine dinucleotide phosphate) has been proposed as a second messenger for glutamate in neuronal and glial cells via the activation of the lysosomal Ca2+ channels TPC1 and TPC2.
+11 more
core +4 more sources
Journal of Lipid Research, 2003 It has been reported that an accumulation of cholesterol within late endosomes/lysosomes in Niemann-Pick type C (NPC) fibroblasts and U18666A-treated cells causes impairment of retrograde trafficking of the cation-independent mannose 6-phosphate/IGF-II ...
Atsushi Umeda +5 more
doaj +1 more source
Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging. [PDF]
, 2017 Mechanistic understanding of the endocytosis and intracellular trafficking of nanoparticles is essential for designing smart theranostic carriers. Physico-chemical properties, including size, clustering and surface chemistry of nanoparticles regulate ...
Chen, Nan +13 more
core +2 more sources
Deciphering tuberculosis: lysosome-centric insights into pathogenesis and therapies
Frontiers in Cellular and Infection MicrobiologyTuberculosis is a widely spread disease caused by Mycobacterium tuberculosis (Mtb). The pathogenicity of the pathogen is closely associated with the immune defense mechanisms of the host cells. As key cellular degradation and metabolic centers, lysosomes
Cui Bao +10 more
doaj +1 more source
In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons
Biosensors, 2022 Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies against Aβ capture
Alec K. McKendell +5 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity[S]
Journal of Lipid Research, 2015 Autophagy is a catabolic process involved in maintaining energy and organelle homeostasis. The relationship between obesity and the regulation of autophagy is cell type specific.
Bharat Jaishy +9 more
doaj +1 more source
Manifestations of Age on Autophagy, Mitophagy and Lysosomes in Skeletal Muscle
Cells, 2021 Sarcopenia is the loss of both muscle mass and function with age. Although the molecular underpinnings of sarcopenia are not fully understood, numerous pathways are implicated, including autophagy, in which defective cargo is selectively identified and ...
Matthew Triolo, David A. Hood
doaj +1 more source
Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells. [PDF]
, 2017 Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML).
Arbiser, Jack L +6 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source