Results 11 to 20 of about 171,488 (262)
“LRRK2: Autophagy and Lysosomal Activity”
Frontiers in Neuroscience, 2020 It has been 15 years since the Leucine-rich repeat kinase 2 (LRRK2) gene was identified as the most common genetic cause for Parkinson’s disease (PD). The two most common mutations are the LRRK2-G2019S, located in the kinase domain, and the LRRK2-R1441C,
Marta Madureira +3 more
doaj +1 more source
, 2023 While lysosomes have popularly been tokened the “disposal system of the cell,” it is being uncovered that they play an important role in more cellular processes, like apoptosis and assisting the immune system.
Gheen, Caroline
core +1 more source
Fusion of intracellular leptospires with lysosomes or caveolae-based vesicles.
, 2022 A: Co-localization of phagocytotic vesicles with lysosomes (LAMP-1) in the THP-1 and HUVEC infected with L. interrogans strain Lai for the indicated times. The green spots marked with LAMP-1 indicate the lysosomes.
Yaling Yang (746000) +6 more
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Pathophysiology of Lysosomes in a Nutshell
, 2023 Lysosomes are acidic organelles present in all nucleated mammalian cells [...]
Ciro Isidoro, Isidoro, Ciro
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Granular Cell Transformation in Plexiform Ameloblastoma: Case Report and Literature Review [PDF]
International Journal of Scientific Research in Dental and Medical SciencesAmeloblastoma is the most common odontogenic tumor, primarily occurring in the posterior mandible. It is a slow-growing yet locally invasive epithelial tumor that generally follows a benign course.
Aravindan S +5 more
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A Ratiometric Fluorescent Probe for Hypochlorite and Lipid Droplets to Monitor Oxidative Stress
Biosensors, 2023 Mitochondria are valuable subcellular organelles and play crucial roles in redox signaling in living cells. Substantial evidence proved that mitochondria are one of the critical sources of reactive oxygen species (ROS), and overproduction of ROS ...
Mousumi Baruah +4 more
doaj +1 more source
LYSOSOME-DEPENDENT CELL DEATH DEFINES SPECIFIC ENDOTHELIAL TOXICITY OF CALCIUM PHOSPHATE BIONS
Сибирский научный медицинский журнал, 2019 Aim of the study was to identify the mechanism of specific endothelial toxicity related to calcium phosphate bions (CPB). Material and methods. CPB and magnesium phosphate bions (MPB) were artificially synthesised through supersaturation of culture ...
D. K. Shishkova +7 more
doaj +1 more source
mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival [PDF]
, 2015 Funding provided by: Wellcome Trust Technology Platform 097945/B/11/Z, MRC Next Generation Optical Microscopy MR/K015869/1, Medical Research Council, Division of Signal Transduction Therapy Unit (AstraZeneca, Boehringer‐Ingelheim, GlaxoSmithKline, Merck ...
Michael J Munson +12 more
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Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes
Cell Reports, 2018 Variants in the phospholipase D3 (PLD3) gene have genetically been linked to late-onset Alzheimer's disease. We present a detailed biochemical analysis of PLD3 and reveal its endogenous localization in endosomes and lysosomes. PLD3 reaches lysosomes as a
Adriana Carolina Gonzalez +6 more
doaj +1 more source
mSphere, 2018 Trypanosoma cruzi, the etiologic agent of Chagas disease, undergoes drastic metabolic changes when it transits between a vector and mammalian hosts. Amino acid catabolism leads to the production of ammonium (NH4+), which needs to be detoxified.
Teresa Cruz-Bustos +3 more
doaj +1 more source