Results 11 to 20 of about 140,536 (267)
eLifeThe formation of large endolysosomal structures in unfertilized eggs ensures that lysosomes remain dormant before fertilization, and then shift into clean-up mode after the egg-to-embryo transition.
Deepak Adhikari, John Carroll
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Lysosome-endosome fusion and lysosome biogenesis [PDF]
Journal of Cell Science, 2000 ABSTRACT Recent data both from cell-free experiments and from cultured cells have shown that lysosomes can fuse directly with late endosomes to form a hybrid organelle. This has a led to a hypothesis that dense core lysosomes are in essence storage granules for acid hydrolases and that, when the former fuse with late endosomes, a ...
J P, Luzio +5 more
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The Biogenesis of Lysosomes and Lysosome-Related Organelles [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 Lysosomes were once considered the end point of endocytosis, simply used for macromolecule degradation. They are now recognized to be dynamic organelles, able to fuse with a variety of targets and to be re-formed after fusion events. They are also now known to be the site of nutrient sensing and signaling to the cell nucleus. In addition, lysosomes are
J Paul, Luzio +3 more
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Granular Cell Transformation in Plexiform Ameloblastoma: Case Report and Literature Review [PDF]
International Journal of Scientific Research in Dental and Medical SciencesAmeloblastoma is the most common odontogenic tumor, primarily occurring in the posterior mandible. It is a slow-growing yet locally invasive epithelial tumor that generally follows a benign course.
Aravindan S +5 more
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A Ratiometric Fluorescent Probe for Hypochlorite and Lipid Droplets to Monitor Oxidative Stress
Biosensors, 2023 Mitochondria are valuable subcellular organelles and play crucial roles in redox signaling in living cells. Substantial evidence proved that mitochondria are one of the critical sources of reactive oxygen species (ROS), and overproduction of ROS ...
Mousumi Baruah +4 more
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Lysosome Transport as a Function of Lysosome Diameter
PLoS ONE, 2014 Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along microtubules. We sought to determine how lysosome diameter influences lysosome transport.
Debjyoti Bandyopadhyay +4 more
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LYSOSOME-DEPENDENT CELL DEATH DEFINES SPECIFIC ENDOTHELIAL TOXICITY OF CALCIUM PHOSPHATE BIONS
Сибирский научный медицинский журнал, 2019 Aim of the study was to identify the mechanism of specific endothelial toxicity related to calcium phosphate bions (CPB). Material and methods. CPB and magnesium phosphate bions (MPB) were artificially synthesised through supersaturation of culture ...
D. K. Shishkova +7 more
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Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes
Cell Reports, 2018 Variants in the phospholipase D3 (PLD3) gene have genetically been linked to late-onset Alzheimer's disease. We present a detailed biochemical analysis of PLD3 and reveal its endogenous localization in endosomes and lysosomes. PLD3 reaches lysosomes as a
Adriana Carolina Gonzalez +6 more
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mSphere, 2018 Trypanosoma cruzi, the etiologic agent of Chagas disease, undergoes drastic metabolic changes when it transits between a vector and mammalian hosts. Amino acid catabolism leads to the production of ammonium (NH4+), which needs to be detoxified.
Teresa Cruz-Bustos +3 more
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Targeting the sAC-Dependent cAMP Pool to Prevent SARS-Cov-2 Infection
Cells, 2020 An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption ...
Muhammad Aslam, Yury Ladilov
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