Results 1 to 10 of about 107,252 (310)

Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor

Membranes, 2015
The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family.
Wymke Ockenga, Ritva Tikkanen
doaj   +1 more source

Inhibition of early EHDV2-Ibaraki infection steps in bovine cells by endosome alkalinization or ikarugamycin, but not by blockage of individual endocytic pathways

Frontiers in Cellular and Infection Microbiology
The Epizootic hemorrhagic disease virus (EHDV), an orbivirus, is the etiological factor of a fatal hemorrhagic disease of wild ruminants. A subset of EHDV serotypes, including the Ibaraki strain of EHDV2 (EHDV2-Ibaraki), infect and cause disease in ...
Maya Malka, Inbar Czaczkes, Shlomi Kashkash, Shirel Shachar, Eran Bacharach, Marcelo Ehrlich   +5 more
doaj   +1 more source

Lamp1 Increases the Efficiency of Lassa Virus Infection by Promoting Fusion in Less Acidic Endosomal Compartments

mBio, 2018
Lassa virus (LASV) is an arenavirus whose entry into host cells is mediated by a glycoprotein complex (GPC) comprised of a receptor binding subunit, GP1, a fusogenic transmembrane subunit, GP2, and a stable signal peptide.
Christine E. Hulseberg, Lucie Fénéant, Katarzyna M. Szymańska, Judith M. White   +3 more
doaj   +1 more source

Distribution and trafficking of MPR300 is normal in cells with cholesterol accumulated in late endocytic compartments

Journal of Lipid Research, 2003
It has been reported that an accumulation of cholesterol within late endosomes/lysosomes in Niemann-Pick type C (NPC) fibroblasts and U18666A-treated cells causes impairment of retrograde trafficking of the cation-independent mannose 6-phosphate/IGF-II ...
Atsushi Umeda, Hideaki Fujita, Toshio Kuronita, Kaori Hirosako, Masaru Himeno, Yoshitaka Tanaka   +5 more
doaj   +1 more source

Endomembrane-Based Signaling by GPCRs and G-Proteins

Cells, 2022
G-protein-coupled receptors (GPCRs) and G-proteins have a range of roles in many physiological and pathological processes and are among the most studied signaling proteins. A plethora of extracellular stimuli can activate the GPCR and can elicit distinct
Federica Liccardo, Alberto Luini, Rosaria Di Martino   +2 more
doaj   +1 more source

Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding

eLife, 2017
The ESCRT machinery mediates reverse membrane scission. By quantitative fluorescence lattice light-sheet microscopy, we have shown that ESCRT-III subunits polymerize rapidly on yeast endosomes, together with the recruitment of at least two Vps4 hexamers.
Manuel Alonso Y Adell, Simona M Migliano, Srigokul Upadhyayula, Yury S Bykov, Simon Sprenger, Mehrshad Pakdel, Georg F Vogel, Gloria Jih, Wesley Skillern, Reza Behrouzi, Markus Babst, Oliver Schmidt, Michael W Hess, John AG Briggs, Tomas Kirchhausen, David Teis   +15 more
doaj   +1 more source

A Role of Phosphatidylserine in the Function of Recycling Endosomes

Frontiers in Cell and Developmental Biology, 2021
Cells internalize proteins and lipids in the plasma membrane (PM) and solutes in the extracellular space by endocytosis. The removal of PM by endocytosis is constantly balanced by the replenishment of proteins and lipids to PM through recycling pathway ...
Junya Hasegawa, Yasunori Uchida, Kojiro Mukai, Shoken Lee, Tatsuyuki Matsudaira, Tomohiko Taguchi   +5 more
doaj   +1 more source

Influence of NAADP and bafilomycine A1 on activity of ATPase in liver postmitochondrial fraction

Біологічні студії, 2015
Recycling of the endo-lysosomal organelles occur by permanent in the cell. This store is thought to be the acidic store because V-type of H+-ATPase is responsible for their acidification.
S. Bychkova
doaj   +1 more source

Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site

Viruses, 2017
African swine fever virus (ASFV) infection causes endosomal reorganization. Here, we show that the virus causes endosomal congregation close to the nucleus as the infection progresses, which is necessary to build a compact viral replication organelle ...
Miguel Ángel Cuesta-Geijo, Lucía Barrado-Gil, Inmaculada Galindo, Raquel Muñoz-Moreno, Covadonga Alonso   +4 more
doaj   +1 more source

Transferrin receptor-mediated internalization and intracellular fate of conjugates of a DNA aptamer

Molecular Therapy: Nucleic Acids, 2022
Aptamers have excellent specificity and affinity in targeting cell surface receptors, showing great potential in targeted delivery of drugs, siRNA, mRNA, and various nanomaterials with therapeutic function.
Nan Zhang, Junyan Wang, Tao Bing, Xiangjun Liu, Dihua Shangguan   +4 more
doaj   +1 more source