Results 1 to 10 of about 113,399 (298)

CROP2, a Retriever–PROPPIN complex mediating protein export from endosomes to the plasma membrane in human cells [PDF]

eLife
Endosomes generate tubulo-vesicular carriers to redistribute proteins between plasma membrane, Golgi, and lysosomes. These transport routes employ distinct combinations of sorting nexins with complexes such as Retromer or Retriever.
Maria Giovanna De Leo, Andreas Mayer
doaj   +2 more sources

The Coordination of Local Translation, Membranous Organelle Trafficking, and Synaptic Plasticity in Neurons

Frontiers in Cell and Developmental Biology, 2021
Neurons are highly complex polarized cells, displaying an extraordinary degree of spatial compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local protein synthesis is utilized to continually modify the synaptic proteome,
Dipen Rajgor, Theresa M. Welle, Katharine R. Smith   +2 more
doaj   +1 more source

Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA

Journal of Extracellular Vesicles, 2022
One of the functions of small extracellular vesicles (sEVs) which has received the most attention is their capacity to deliver RNA into the cytoplasm of target cells.
Jenna McCann, Carmen Daniela Sosa‐Miranda, Huishan Guo, Ryan Reshke, Alexandre Savard, Adriana Zardini Buzatto, James A. Taylor, Liang Li, Derrick J. Gibbings   +8 more
doaj   +1 more source

Vibrio gazogenes-dependent disruption of aflatoxin biosynthesis in Aspergillus flavus: the connection with endosomal uptake and hyphal morphogenesis

Frontiers in Microbiology, 2023
Aflatoxins, a family of fungal secondary metabolites, are toxic and carcinogenic compounds that pose an enormous threat to global food safety and agricultural sustainability.
Rubaiya Jesmin, Jeffrey W. Cary, Matthew D. Lebar, Rajtilak Majumdar, Phani M. Gummadidala, Travis Dias, Savannah Chandler, Paramita Basu, Alan W. Decho, Nancy P. Keller, Anindya Chanda   +10 more
doaj   +1 more source

Rab2 drives axonal transport of dense core vesicles and lysosomal organelles

Cell Reports, 2021
Summary: Fast axonal transport of neuropeptide-containing dense core vesicles (DCVs), endolysosomal organelles, and presynaptic components is critical for maintaining neuronal functionality.
Viktor Karlovich Lund, Matthew Domenic Lycas, Anders Schack, Rita Chan Andersen, Ulrik Gether, Ole Kjaerulff   +5 more
doaj   +1 more source

Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia

Cells, 2021
Hereditary spastic paraplegia (HSP) refers to a group of neurological disorders involving the degeneration of motor neurons. Due to their clinical and genetic heterogeneity, finding common effective therapeutics is difficult.
Liriopé Toupenet Marchesi, Marion Leblanc, Giovanni Stevanin   +2 more
doaj   +1 more source

Exosomal sorting of the viral oncoprotein LMP1 is restrained by TRAF2 association at signalling endosomes [PDF]

Journal of Extracellular Vesicles, 2015
The Epstein–Barr virus (EBV)-encoded oncoprotein latent membrane protein 1 (LMP1) constitutively activates nuclear factor κB (NFκB) from intracellular membranes to promote cell growth and survival. LMP1 associates with CD63 in intracellular membranes and
Frederik J. Verweij, Cecilia de Heus, Stefanie Kroeze, Houjian Cai, Elliott Kieff, Sander R. Piersma, Connie R. Jimenez, Jaap M. Middeldorp, Dirk Michiel Pegtel   +8 more
doaj   +1 more source

Local Analysis of Heterogeneous Intracellular Transport: Slow and Fast Moving Endosomes

Entropy, 2021
Trajectories of endosomes inside living eukaryotic cells are highly heterogeneous in space and time and diffuse anomalously due to a combination of viscoelasticity, caging, aggregation and active transport.
Nickolay Korabel, Daniel Han, Alessandro Taloni, Gianni Pagnini, Sergei Fedotov, Viki Allan, Thomas Andrew Waigh   +6 more
doaj   +1 more source

Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor

Membranes, 2015
The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family.
Wymke Ockenga, Ritva Tikkanen
doaj   +1 more source

A promising RNA nanotechnology in clinical therapeutics: a future perspective narrative review

Future Science OA, 2023
Nanotechnology is the use of materials that have unique nanoscale properties. In recent years, nanotechnologies have shown promising results for human health, especially in cancer treatment. The self-assembly characteristic of RNA is a powerful bottom-up
Mahmoud M Tolba, Abdul Jabbar, Sadia Afzal, Mohammed Mahmoud, Farheen Zulfiqar, Ingy El-Soudany, Salma Samir, Al-Hassan Soliman Wadan, Takwa E Ellakwa, Doha El-Sayed Ellakwa   +9 more
doaj   +1 more source