Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function [PDF]
, 2011 Cholesterol regulates plasma membrane (PM) association and functioning of syntaxin-4 and soluble N-ethylmaleimide-sensitive fusion protein 23 (SNAP23) in the secretory pathway.
Enrich Bastús, Carles +32 more
core +1 more source
Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site
Viruses, 2017 African swine fever virus (ASFV) infection causes endosomal reorganization. Here, we show that the virus causes endosomal congregation close to the nucleus as the infection progresses, which is necessary to build a compact viral replication organelle ...
Miguel Ángel Cuesta-Geijo +4 more
doaj +1 more source
Crinum latifolium extract inhibits lipopolysaccharide-induced inflammation in human macrophages
Romanian Journal of Laboratory Medicine, 2022 Introduction: Crinum latifolium is a natural plant showing the anti-inflammatory effects. We aimed to evaluate the effects of Crinum latifolium extract on proinflammatory cytokine production and maturation of early and late endosomes in the ...
Köktürk Sibel +2 more
doaj +1 more source
Proton-Activated Chloride Channel: Physiology and Disease
Frontiers in Bioscience-Landmark, 2023 The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes ...
Fanglin Peng +3 more
doaj +1 more source
Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells [PDF]
, 2012 Carbon nanotubes (CNTs) are at present being considered as potential nanovectors with the ability to deliver therapeutic cargoes into living cells. Previous studies established the ability of CNTs to enter cells and their therapeutic utility, but an ...
Silva, S. Ravi P. +17 more
core +1 more source
Novel exc Genes Involved in Formation of the Tubular Excretory Canals of Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2019 Regulation of luminal diameter is critical to the function of small single-celled tubes, of which the seamless tubular excretory canals of Caenorhabditis elegans provide a tractable genetic model.
Hikmat Al-Hashimi +3 more
doaj +1 more source
Targeting endosomal pH for cancer chemotherapy
Molecular & Cellular Oncology, 2018 Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance ...
Fabrice Lucien +2 more
doaj +1 more source
Mechanisms of Entry and Endosomal Pathway of African Swine Fever Virus
Vaccines, 2017 African Swine Fever Virus (ASFV) causes a serious swine disease that is endemic in Africa and Sardinia and presently spreading in Russia and neighboring countries, including Poland and recently, the Czech Republic.
Elena G. Sánchez +2 more
doaj +1 more source
The endocytic pathway taken by cationic substances requires Rab14 but not Rab5 and Rab7
Cell Reports, 2021 Summary: Endocytosis and endosome dynamics are controlled by proteins of the small GTPase Rab family. Besides possible recycling routes to the plasma membrane and various organelles, previously described endocytic pathways (e.g., clathrin-mediated ...
Evgeniya Trofimenko +3 more
doaj +1 more source
A microscopy-based kinetic analysis of yeast vacuolar protein sorting
eLife, 2020 Saccharomyces cerevisiae is amenable to studying membrane traffic by live-cell fluorescence microscopy. We used this system to explore two aspects of cargo protein traffic through prevacuolar endosome (PVE) compartments to the vacuole.
Jason C Casler, Benjamin S Glick
doaj +1 more source