Results 21 to 30 of about 107,252 (310)
The endocytic pathway taken by cationic substances requires Rab14 but not Rab5 and Rab7
Cell Reports, 2021 Summary: Endocytosis and endosome dynamics are controlled by proteins of the small GTPase Rab family. Besides possible recycling routes to the plasma membrane and various organelles, previously described endocytic pathways (e.g., clathrin-mediated ...
Evgeniya Trofimenko +3 more
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A microscopy-based kinetic analysis of yeast vacuolar protein sorting
eLife, 2020 Saccharomyces cerevisiae is amenable to studying membrane traffic by live-cell fluorescence microscopy. We used this system to explore two aspects of cargo protein traffic through prevacuolar endosome (PVE) compartments to the vacuole.
Jason C Casler, Benjamin S Glick
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Oncotarget, 2015 Phosphoinositide 3-kinase (PI3K) and AKT define a signaling network that regulates important biological processes such as cell cycle, survival, metabolism and motility, all of which are disrupted in cancer (Figure (Figure1)1) [1]. Hyperactivation of PI3K leads to increased production of phosphoinositide (PI) species such as PI(3,4,5)P3 and PI(3,4)P2 ...
Chew, Chen Li +2 more
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Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes [PDF]
The Journal of cell biology, 1992 After endocytosis, lysosomally targeted ligands pass through a series of endosomal compartments. The endocytic apparatus that accomplishes this passage may be considered to take one of two forms: (a) a system in which lysosomally targeted ligands pass through preexisting, long-lived early sorting endosomes and are then selectively transported to long ...
K W, Dunn, F R, Maxfield
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Frontiers in Cell and Developmental Biology, 2021 Neurons are highly complex polarized cells, displaying an extraordinary degree of spatial compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local protein synthesis is utilized to continually modify the synaptic proteome,
Dipen Rajgor +2 more
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An ESCRT into the Endosome [PDF]
Molecular Cell, 2002 Multivesicular endosomes sort ubiquitinated membrane proteins for degradation by incorporating them into inwardly budding vesicles. The recent identification of two new oligomeric components of the sorting machinery gives us a detailed view of the complex protein-protein interactions driving this process.
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Rabaptin5 is recruited to endosomes by Rab4a and Rabex5 to regulate endosome maturation [PDF]
, 2014 Membrane trafficking between organelles is fundamental to the existence of eukaryotic cells. A multitude of proteins is involved in membrane trafficking, acting as building blocks for transport carriers, regulators of transport, and targeting and fusion ...
Kälin, Simone
core +1 more source
Journal of Extracellular Vesicles, 2022 One of the functions of small extracellular vesicles (sEVs) which has received the most attention is their capacity to deliver RNA into the cytoplasm of target cells.
Jenna McCann +8 more
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Frontiers in Microbiology, 2023 Aflatoxins, a family of fungal secondary metabolites, are toxic and carcinogenic compounds that pose an enormous threat to global food safety and agricultural sustainability.
Rubaiya Jesmin +10 more
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Participation of Endosomes in Toll-Like Receptor 3 Transportation Pathway in Murine Astrocytes
Frontiers in Cellular Neuroscience, 2020 TLR3 provides immediate type I IFN response following entry of stimulatory PAMPs into the CNS, as it is in HSV infection. The receptor plays a vital role in astrocytes, contributing to rapid infection sensing and suppression of viral replication ...
Matylda B. Mielcarska +11 more
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