Results 21 to 30 of about 113,399 (298)
Journal of Lipid Research, 2003 It has been reported that an accumulation of cholesterol within late endosomes/lysosomes in Niemann-Pick type C (NPC) fibroblasts and U18666A-treated cells causes impairment of retrograde trafficking of the cation-independent mannose 6-phosphate/IGF-II ...
Atsushi Umeda +5 more
doaj +1 more source
eLife, 2017 The ESCRT machinery mediates reverse membrane scission. By quantitative fluorescence lattice light-sheet microscopy, we have shown that ESCRT-III subunits polymerize rapidly on yeast endosomes, together with the recruitment of at least two Vps4 hexamers.
Manuel Alonso Y Adell +15 more
doaj +1 more source
Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles
Antioxidants, 2022 KEAP1 is a cytoplasmic protein that functions as an adaptor for the Cullin-3-based ubiquitin E3 ligase system, which regulates the degradation of many proteins, including NFE2L2/NRF2 and p62/SQSTM1.
Elisabet Uribe-Carretero +12 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Tight-junction (TJ) proteins are essential for establishing the barrier function between neighbor epithelial cells, but also for recognition of pathogens or cell migration.
Clara Maria Mateos-Quiros +8 more
doaj +1 more source
Current Opinion in Cell Biology, 2015 The endosomal membrane recycling system represents a dynamic conduit for sorting and re-exporting internalized membrane constituents. The recycling system is composed of multiple tubulovesicular recycling pathways that likely confer distinct trafficking pathways for individual cargoes.
openaire +2 more sources
Rabaptin5 is recruited to endosomes by Rab4a and Rabex5 to regulate endosome maturation [PDF]
, 2014 Membrane trafficking between organelles is fundamental to the existence of eukaryotic cells. A multitude of proteins is involved in membrane trafficking, acting as building blocks for transport carriers, regulators of transport, and targeting and fusion ...
Kälin, Simone
core +1 more source
Influence of NAADP and bafilomycine A1 on activity of ATPase in liver postmitochondrial fraction
Біологічні студії, 2015 Recycling of the endo-lysosomal organelles occur by permanent in the cell. This store is thought to be the acidic store because V-type of H+-ATPase is responsible for their acidification.
S. Bychkova
doaj +1 more source
Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function [PDF]
, 2011 Cholesterol regulates plasma membrane (PM) association and functioning of syntaxin-4 and soluble N-ethylmaleimide-sensitive fusion protein 23 (SNAP23) in the secretory pathway.
Enrich Bastús, Carles +25 more
core +1 more source
Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site
Viruses, 2017 African swine fever virus (ASFV) infection causes endosomal reorganization. Here, we show that the virus causes endosomal congregation close to the nucleus as the infection progresses, which is necessary to build a compact viral replication organelle ...
Miguel Ángel Cuesta-Geijo +4 more
doaj +1 more source
The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network [PDF]
, 2008 The small-molecule inhibitor Exo2 {4-hydroxy-3-methoxy-(5,6,7,8-tetrahydrol[1]benzothieno[2,3-d]pyrimidin-4-yl)hydraz-one benzaldehyde} has been reported to disrupt the Golgi apparatus completely and to stimulate Golgi–ER (endoplasmic reticulum) fusion ...
Amessou, M +37 more
core +1 more source