Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells [PDF]
, 2012 Carbon nanotubes (CNTs) are at present being considered as potential nanovectors with the ability to deliver therapeutic cargoes into living cells. Previous studies established the ability of CNTs to enter cells and their therapeutic utility, but an ...
Silva, S. Ravi P. +17 more
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The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network [PDF]
, 2008 The small-molecule inhibitor Exo2 {4-hydroxy-3-methoxy-(5,6,7,8-tetrahydrol[1]benzothieno[2,3-d]pyrimidin-4-yl)hydraz-one benzaldehyde} has been reported to disrupt the Golgi apparatus completely and to stimulate Golgi–ER (endoplasmic reticulum) fusion ...
Amessou, M +37 more
core +1 more source
Auxin Signaling in Regulation of Plant Translation Reinitiation
Frontiers in Plant Science, 2017 The mRNA translation machinery directs protein production, and thus cell growth, according to prevailing cellular and environmental conditions. The target of rapamycin (TOR) signaling pathway—a major growth-related pathway—plays a pivotal role in ...
Mikhail Schepetilnikov +1 more
doaj +1 more source
Current Opinion in Cell Biology, 2015 The endosomal membrane recycling system represents a dynamic conduit for sorting and re-exporting internalized membrane constituents. The recycling system is composed of multiple tubulovesicular recycling pathways that likely confer distinct trafficking pathways for individual cargoes.
openaire +2 more sources
Vaccinia Virus Infection Requires Maturation of Macropinosomes. [PDF]
, 2015 The prototypic poxvirus, vaccinia virus (VACV), occurs in two infectious forms, mature virions (MVs) and extracellular virions (EVs). Both enter HeLa cells by inducing macropinocytic uptake.
Mercer, Jason +13 more
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Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts
Journal of Lipid Research, 2002 The dynamics of endolysosomal cholesterol were investigated in Niemann-Pick type C (NPC) cells and in human fibroblasts treated with class 2 amphiphiles to mimic NPC cells.
Yvonne Lange +3 more
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Rab2 drives axonal transport of dense core vesicles and lysosomal organelles
Cell Reports, 2021 Summary: Fast axonal transport of neuropeptide-containing dense core vesicles (DCVs), endolysosomal organelles, and presynaptic components is critical for maintaining neuronal functionality.
Viktor Karlovich Lund +5 more
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Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia
Cells, 2021 Hereditary spastic paraplegia (HSP) refers to a group of neurological disorders involving the degeneration of motor neurons. Due to their clinical and genetic heterogeneity, finding common effective therapeutics is difficult.
Liriopé Toupenet Marchesi +2 more
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Retromer-Mediated Trafficking of Transmembrane Receptors and Transporters
Membranes, 2015 Transport between the endoplasmatic reticulum, the Golgi-network, the endo-lysosomal system and the cell surface can be categorized as anterograde or retrograde, describing traffic that goes forward or backward, respectively.
Stine C. Klinger +2 more
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Exosomal sorting of the viral oncoprotein LMP1 is restrained by TRAF2 association at signalling endosomes [PDF]
Journal of Extracellular Vesicles, 2015 The Epstein–Barr virus (EBV)-encoded oncoprotein latent membrane protein 1 (LMP1) constitutively activates nuclear factor κB (NFκB) from intracellular membranes to promote cell growth and survival. LMP1 associates with CD63 in intracellular membranes and
Frederik J. Verweij +8 more
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