Results 31 to 40 of about 113,399 (298)
Crinum latifolium extract inhibits lipopolysaccharide-induced inflammation in human macrophages
Romanian Journal of Laboratory Medicine, 2022 Introduction: Crinum latifolium is a natural plant showing the anti-inflammatory effects. We aimed to evaluate the effects of Crinum latifolium extract on proinflammatory cytokine production and maturation of early and late endosomes in the ...
Köktürk Sibel +2 more
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Proton-Activated Chloride Channel: Physiology and Disease
Frontiers in Bioscience-Landmark, 2023 The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes ...
Fanglin Peng +3 more
doaj +1 more source
Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells [PDF]
, 2012 Carbon nanotubes (CNTs) are at present being considered as potential nanovectors with the ability to deliver therapeutic cargoes into living cells. Previous studies established the ability of CNTs to enter cells and their therapeutic utility, but an ...
Silva, S. Ravi P. +17 more
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Vaccinia Virus Infection Requires Maturation of Macropinosomes. [PDF]
, 2015 The prototypic poxvirus, vaccinia virus (VACV), occurs in two infectious forms, mature virions (MVs) and extracellular virions (EVs). Both enter HeLa cells by inducing macropinocytic uptake.
Mercer, Jason +13 more
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Novel exc Genes Involved in Formation of the Tubular Excretory Canals of Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2019 Regulation of luminal diameter is critical to the function of small single-celled tubes, of which the seamless tubular excretory canals of Caenorhabditis elegans provide a tractable genetic model.
Hikmat Al-Hashimi +3 more
doaj +1 more source
Guiding Endosomal Maturation [PDF]
Cell, 2010 In the endocytic pathway, early endosomes are converted into late endosomes by exchange of their associated Rab GTPases. In this issue, Poteryaev et al. (2010) identify the SAND-1/Mon1 protein as a switch that shuts off the recruitment of one Rab (Rab5) and facilitates the activation of the next (Rab7).
Cabrera, Margarita, Ungermann, Christian
openaire +2 more sources
Targeting endosomal pH for cancer chemotherapy
Molecular & Cellular Oncology, 2018 Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance ...
Fabrice Lucien +2 more
doaj +1 more source
Cloud storage for endosomes [PDF]
The EMBO Journal, 2016 Coordinated regulation of vesicle trafficking is critical for the proper functioning of a cell. The bulk of cellular transport vesicles are sequestered in a “perinuclear cloud”, with only a small fraction released to the cell periphery. Jongsma et al (2016) found that the ER‐associated E3 ubiquitin ligase RNF26 is responsible for establishing and ...
Teegan, Dellibovi-Ragheb +1 more
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Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [PDF]
, 2007 Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the ...
Evelyn Fuchs +18 more
core +1 more source
Mechanisms of Entry and Endosomal Pathway of African Swine Fever Virus
Vaccines, 2017 African Swine Fever Virus (ASFV) causes a serious swine disease that is endemic in Africa and Sardinia and presently spreading in Russia and neighboring countries, including Poland and recently, the Czech Republic.
Elena G. Sánchez +2 more
doaj +1 more source