Results 11 to 20 of about 113,399 (298)
Early endosomes and endosomal coatomer are required for autophagy [PDF]
Journal of Cell Biology, 2009 Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes sequester and enclose cytosolic components and organelles, and subsequently fuse with the endosomal pathway allowing content degradation.
Razi, M. +2 more
core +10 more sources
Plasticity of early endosomes [PDF]
Journal of Cell Science, 1992 ABSTRACT We observed that the structural organization of early endosomes was significantly modified after cell surface biotinylation followed by incubation in the presence of low concentrations of avidin. Under these conditions early endosomes increased in size to form structures which extended over several micrometres and which had an ...
Parton, R. G. +3 more
core +6 more sources
Journal of Cell Science, 2006 The endocytic and exocytic system is important for cells to communicate with their surroundings. For instance, endocytosis allows the regulated internalisation of receptors (which can be ligand bound or not) into peripheral early endosomes and can thus ...
Sven C. D. Van Ijzendoorn +1 more
openaire +5 more sources
P Systems with Endosomes [PDF]
International Journal of Computers Communications & Control, 2009 P Systems are computing devices inspired by the structure and the func- tioning of a living cell. A P System consists of a hierarchy of membranes, each of them containing a multiset of objects, a set of evolution rules, and possibly other membranes. Evolution rules are applied to the objects of the same membrane with maximal parallelism.
BARBUTI, ROBERTO +3 more
core +9 more sources
Protocol for quantifying miRNA trafficking across the endosomal membrane. [PDF]
FEBS Open BioAn in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Ghosh S, Mukherjee K, Bhattacharyya SN.
europepmc +2 more sources
The EMBO Journal, 2011 Being deeply connected to signalling, cell dynamics, growth, regulation, and defence, endocytic processes are linked to almost all aspects of cell life and disease. In this review, we focus on endosomes in the classical endocytic pathway, and on the programme of changes that lead to the formation and maturation of late endosomes/multivesicular bodies ...
Huotari J, Helenius A.
openaire +3 more sources
An ESCRT into the Endosome [PDF]
Molecular Cell, 2002 Multivesicular endosomes sort ubiquitinated membrane proteins for degradation by incorporating them into inwardly budding vesicles. The recent identification of two new oligomeric components of the sorting machinery gives us a detailed view of the complex protein-protein interactions driving this process.
openaire +2 more sources
mBio, 2018 Lassa virus (LASV) is an arenavirus whose entry into host cells is mediated by a glycoprotein complex (GPC) comprised of a receptor binding subunit, GP1, a fusogenic transmembrane subunit, GP2, and a stable signal peptide.
Christine E. Hulseberg +3 more
doaj +1 more source
Oncotarget, 2015 Phosphoinositide 3-kinase (PI3K) and AKT define a signaling network that regulates important biological processes such as cell cycle, survival, metabolism and motility, all of which are disrupted in cancer (Figure (Figure1)1) [1]. Hyperactivation of PI3K leads to increased production of phosphoinositide (PI) species such as PI(3,4,5)P3 and PI(3,4)P2 ...
Chew, Chen Li +2 more
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Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes [PDF]
The Journal of cell biology, 1992 After endocytosis, lysosomally targeted ligands pass through a series of endosomal compartments. The endocytic apparatus that accomplishes this passage may be considered to take one of two forms: (a) a system in which lysosomally targeted ligands pass through preexisting, long-lived early sorting endosomes and are then selectively transported to long ...
K W, Dunn, F R, Maxfield
openaire +3 more sources