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Local Analysis of Heterogeneous Intracellular Transport: Slow and Fast Moving Endosomes
Trajectories of endosomes inside living eukaryotic cells are highly heterogeneous in space and time and diffuse anomalously due to a combination of viscoelasticity, caging, aggregation and active transport.
Nickolay Korabel +6 more
doaj +1 more source
Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]
Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Falguières, Thomas +15 more
core +1 more source
IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells
International audienceDendritic cells (DCs) contribute to the immune surveillance by sampling their environment through phagocytosis and endocytosis. We have previously reported that, rapidly following uptake of extracellular antigen into phagosomes or ...
Weimershaus, Mirjana +5 more
core +1 more source
RETRACTED: Role of Protein VII in the Production of Infectious Bovine Adenovirus-3 Virion
Bovine adenovirus (BAdV)-3 genome encodes a 26 kDa core protein designated as protein VII, which localizes to the nucleus/nucleolus. The requirement of a protein VII-complementing cell line for the replication of VII-deleted BAdV-3 suggests that protein ...
Shermila Kulanayake +3 more
doaj +1 more source
Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling
Without robust mechanisms to efficiently form new synaptic vesicles (SVs), the tens to hundreds of SVs typically present at the neuronal synapse would be rapidly used up, even at modest levels of neuronal activity.
Ira Milosevic
doaj +1 more source
Endosomes are important functional elements of the chemical synapse. They are used in membrane trafficking pathways controlling recycling and degradation of pre- and post-synaptic membrane proteins.
Shupliakov, O,, Haucke, V
core +1 more source
Guiding Endosomal Maturation [PDF]
In the endocytic pathway, early endosomes are converted into late endosomes by exchange of their associated Rab GTPases. In this issue, Poteryaev et al. (2010) identify the SAND-1/Mon1 protein as a switch that shuts off the recruitment of one Rab (Rab5) and facilitates the activation of the next (Rab7).
Cabrera, Margarita, Ungermann, Christian
openaire +2 more sources
Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [PDF]
Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the ...
Evelyn Fuchs +18 more
core +1 more source
FERARI and cargo adaptors coordinate cargo flow through sorting endosomes [PDF]
Cellular organization, compartmentalization and cell-to-cell communication are crucially dependent on endosomal pathways. Sorting endosomes provide a transit point for various trafficking pathways and decide the fate of proteins: recycling, secretion or ...
Solinger, Jachen A. +3 more
core +1 more source
Cholesterol regulates plasma membrane (PM) association and functioning of syntaxin-4 and soluble N-ethylmaleimide-sensitive fusion protein 23 (SNAP23) in the secretory pathway.
Enrich Bastús, Carles +25 more
core +1 more source

