Results 61 to 70 of about 114,580 (255)

Hepatocyte Autophagy in Malaria: Current Concepts, Emerging Mechanisms, and Future Therapeutic Directions

Pathogens
The liver stage of Plasmodium infection represents a critical bottleneck in malaria pathogenesis and a unique interface between parasite development and hepatocyte-intrinsic immunity. Recent evidence suggests that hepatocytes do not eliminate liver-stage
Afiat Berbudi, Shafia Khairani, Endang Yuni Setyowati, Alexander Kwarteng   +3 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

FAM21C drives hepatocellular carcinoma invasion and migration by regulating recycling endosome-mediated MT1-MMP transport to promote invadopodia formation

陆军军医大学学报
Objective The highly invasive and metastatic characteristics of hepatocellular carcinoma(HCC) are the primary contributors to the extremely poor prognosis of the patients.
YANG Zhiyuan, ZHENG Shuguo
doaj   +1 more source

Vγ9Vδ2 T Cells Activation Through Phosphoantigens Can Be Impaired by a RHOB Rerouting in Lung Cancer

Frontiers in Immunology, 2020
Vγ9Vδ2 T cells are known to be efficient anti-tumor effectors activated through phosphoantigens (PAg) that are naturally expressed by tumor cells or induced by amino bisphosphonates treatment.
Chloé Laplagne, Chloé Laplagne, Chloé Laplagne, Sarah Meddour, Sarah Meddour, Sarah Meddour, Sarah Figarol, Sarah Figarol, Sarah Figarol, Marie Michelas, Marie Michelas, Marie Michelas, Olivier Calvayrac, Olivier Calvayrac, Olivier Calvayrac, Gilles Favre, Gilles Favre, Gilles Favre, Gilles Favre, Camille Laurent, Camille Laurent, Camille Laurent, Camille Laurent, Jean-Jacques Fournié, Jean-Jacques Fournié, Jean-Jacques Fournié, Stéphanie Cabantous, Stéphanie Cabantous, Stéphanie Cabantous, Mary Poupot, Mary Poupot, Mary Poupot   +31 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

RETRACTED: Role of Protein VII in the Production of Infectious Bovine Adenovirus-3 Virion

Viruses
Bovine adenovirus (BAdV)-3 genome encodes a 26 kDa core protein designated as protein VII, which localizes to the nucleus/nucleolus. The requirement of a protein VII-complementing cell line for the replication of VII-deleted BAdV-3 suggests that protein ...
Shermila Kulanayake, Barinder Singh, Faryal Dar, Suresh K. Tikoo   +3 more
doaj   +1 more source

Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling

Frontiers in Cellular Neuroscience, 2018
Without robust mechanisms to efficiently form new synaptic vesicles (SVs), the tens to hundreds of SVs typically present at the neuronal synapse would be rapidly used up, even at modest levels of neuronal activity.
Ira Milosevic
doaj   +1 more source

Plasticity of early endosomes

, 1992
We observed that the structural organization of early endosomes was significantly modified after cell surface biotinylation followed by incubation in the presence of low concentrations of avidin.
PARTON R, GRUENBERG J, BUCCI, Cecilia, SCHROTZ P, PLASTICITY OF EARLY ENDOSOMES   +4 more
core  

Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms

Advanced Functional Materials, EarlyView.
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger, Min Jiang, Florian Belger, Fabian Link, Benjamin Winkeljann, Olivia M. Merkel   +5 more
wiley   +1 more source

Autophagosome maturation in primary rat hepatocytes. [PDF]

, 2006
Nutrient deprivation of eukaryotic cells elicits a rapid survival response, including the induction of autophagy. Autophagy, or "self-eating", involves the formation of autophagosomes from an unknown membrane source and the sequestration of cytosolic ...
Kchl, R., Köchl, Robert
core