Results 71 to 80 of about 114,580 (255)
Advanced Healthcare Materials, EarlyView.Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez +12 more
wiley +1 more source
Externally applied mtDNA localizes to endosomes.
, 2013 HPAEC were reacted with mtDNA labeled with Alexa-488, FM4-64 (a marker for endosomes) and NucBlue (a marker for nuclei). After 4 hr of incubation, cells were examined for dye localization by confocal microscopy. A. nuclei, B. endosomes, and C. mtDNA were
Yi Zheng (113896) +8 more
core +1 more source
Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic
Advanced Robotics Research, EarlyView.Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang +5 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyThe Epizootic hemorrhagic disease virus (EHDV), an orbivirus, is the etiological factor of a fatal hemorrhagic disease of wild ruminants. A subset of EHDV serotypes, including the Ibaraki strain of EHDV2 (EHDV2-Ibaraki), infect and cause disease in ...
Maya Malka +5 more
doaj +1 more source
Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture [PDF]
, 2016 Co-author Sukhee Cho is a doctoral student in the Neuroscience Program in the Morningside Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.Lateral diffusion in the membrane and endosomal trafficking both contribute to the addition ...
Schatzle, Philipp +9 more
core +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen +7 more
wiley +1 more source
Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture
, 2015 Lateral diffusion in the membrane and endosomal trafficking both contribute to the addition and removal of AMPA receptors (AMPARs) at postsynaptic sites.
Adrian, M +32 more
core +1 more source
Advanced Science, EarlyView.A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang +7 more
wiley +1 more source
NPC1 deficiency leads to the enlargement of late endosomes.
, 2013 The % of cytoplasmic volume occupied by late endosomes was determined by quantitative electron microscopy on U18666A treated late endosomes, NPC1 deficient CHO cells and fibroblast from an NPC1 patient [24] in comparison to their respective controls.
Isabelle Le Blanc (34136) +7 more
core +1 more source