Results 81 to 90 of about 113,399 (298)

FAM21C drives hepatocellular carcinoma invasion and migration by regulating recycling endosome-mediated MT1-MMP transport to promote invadopodia formation

陆军军医大学学报
Objective The highly invasive and metastatic characteristics of hepatocellular carcinoma(HCC) are the primary contributors to the extremely poor prognosis of the patients.
YANG Zhiyuan, ZHENG Shuguo
doaj   +1 more source

Vγ9Vδ2 T Cells Activation Through Phosphoantigens Can Be Impaired by a RHOB Rerouting in Lung Cancer

Frontiers in Immunology, 2020
Vγ9Vδ2 T cells are known to be efficient anti-tumor effectors activated through phosphoantigens (PAg) that are naturally expressed by tumor cells or induced by amino bisphosphonates treatment.
Chloé Laplagne, Chloé Laplagne, Chloé Laplagne, Sarah Meddour, Sarah Meddour, Sarah Meddour, Sarah Figarol, Sarah Figarol, Sarah Figarol, Marie Michelas, Marie Michelas, Marie Michelas, Olivier Calvayrac, Olivier Calvayrac, Olivier Calvayrac, Gilles Favre, Gilles Favre, Gilles Favre, Gilles Favre, Camille Laurent, Camille Laurent, Camille Laurent, Camille Laurent, Jean-Jacques Fournié, Jean-Jacques Fournié, Jean-Jacques Fournié, Stéphanie Cabantous, Stéphanie Cabantous, Stéphanie Cabantous, Mary Poupot, Mary Poupot, Mary Poupot   +31 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

RETRACTED: Role of Protein VII in the Production of Infectious Bovine Adenovirus-3 Virion

Viruses
Bovine adenovirus (BAdV)-3 genome encodes a 26 kDa core protein designated as protein VII, which localizes to the nucleus/nucleolus. The requirement of a protein VII-complementing cell line for the replication of VII-deleted BAdV-3 suggests that protein ...
Shermila Kulanayake, Barinder Singh, Faryal Dar, Suresh K. Tikoo   +3 more
doaj   +1 more source

Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling

Frontiers in Cellular Neuroscience, 2018
Without robust mechanisms to efficiently form new synaptic vesicles (SVs), the tens to hundreds of SVs typically present at the neuronal synapse would be rapidly used up, even at modest levels of neuronal activity.
Ira Milosevic
doaj   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

The R-SNARE endobrevin/VAMP-8 mediates homotypic fusion of early endosomes and late endosomes

, 2000
Endobrevin/VAMP-8 is an R-SNARE localized to endosomes, but it is unknown in which intracellular fusion step it operates. Using subcellular fractionation and quantitative immunogold electron microscopy, we found that endobrevin/VAMP-8 is present on all ...
Honing, S., Jahn, R., Tikkanen, R., Antonin, W., Holroyd, C.   +4 more
core   +2 more sources

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source

Inhibition of early EHDV2-Ibaraki infection steps in bovine cells by endosome alkalinization or ikarugamycin, but not by blockage of individual endocytic pathways

Frontiers in Cellular and Infection Microbiology
The Epizootic hemorrhagic disease virus (EHDV), an orbivirus, is the etiological factor of a fatal hemorrhagic disease of wild ruminants. A subset of EHDV serotypes, including the Ibaraki strain of EHDV2 (EHDV2-Ibaraki), infect and cause disease in ...
Maya Malka, Inbar Czaczkes, Shlomi Kashkash, Shirel Shachar, Eran Bacharach, Marcelo Ehrlich   +5 more
doaj   +1 more source