Results 1 to 10 of about 64,892 (258)

Clathrin Light Chains: Not to Be Taken so Lightly

Frontiers in Cell and Developmental Biology, 2021
Clathrin is a cytosolic protein involved in the intracellular trafficking of a wide range of cargo. It is composed of three heavy chains and three light chains that together form a triskelion, the subunit that polymerizes to form a clathrin coated ...
Jyoti Das, Jyoti Das, Mahak Tiwari, Mahak Tiwari, Deepa Subramanyam   +4 more
doaj   +1 more source

Live-cell imaging of endocytosed synaptophysin around individual hippocampal presynaptic active zones

Frontiers in Cellular Neuroscience, 2023
In presynaptic terminals 4 types of endocytosis, kiss-and-run, clathrin-mediated, bulk and ultrafast endocytosis have been reported to maintain repetitive exocytosis of neurotransmitter. However, detailed characteristics and relative contribution of each
Hiromitsu Tanaka, Hiromitsu Tanaka, Junichiro Funahashi, Tomoo Hirano   +3 more
doaj   +1 more source

Arabidopsis clathrin adaptor EPSIN1 but not MODIFIED TRANSPORT TO THE VACOULE1 contributes to effective plant immunity against pathogenic Pseudomonas bacteria

Plant Signaling & Behavior, 2023
In eukaryotes, EPSINs are Epsin N-terminal Homology (ENTH) domain-containing proteins that serve as monomeric clathrin adaptors at the plasma membrane (PM) or the trans-Golgi Network (TGN)/early endosomes (EE).
Kelly Mason, Erica LaMontagne-Mueller, Michael Sauer, Antje Heese   +3 more
doaj   +1 more source

Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization.

PLoS Pathogens, 2009
Many viruses that enter cells by clathrin-dependent endocytosis are significantly larger than the dimensions of a typical clathrin-coated vesicle.
David K Cureton, Ramiro H Massol, Saveez Saffarian, Tomas L Kirchhausen, Sean P J Whelan   +4 more
doaj   +1 more source

Role of Clathrin and Dynamin in Clathrin Mediated Endocytosis/Synaptic Vesicle Recycling and Implications in Neurological Diseases

Frontiers in Cellular Neuroscience, 2022
Endocytosis is a process essential to the health and well-being of cell. It is required for the internalisation and sorting of “cargo”—the macromolecules, proteins, receptors and lipids of cell signalling.
Kate L. Prichard, Nicholas S. O'Brien, Sari R. Murcia, Jennifer R. Baker, Adam McCluskey   +4 more
doaj   +1 more source

Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells

Molecular Cancer, 2013
Background During metaphase clathrin stabilises the mitotic spindle kinetochore(K)-fibres. Many anti-mitotic compounds target microtubule dynamics.
Smith Charlotte M, Haucke Volker, McCluskey Adam, Robinson Phillip J, Chircop Megan   +4 more
doaj   +1 more source

Study on Absorption Mechanism and Tissue Distribution of Fucoidan

Molecules, 2020
Fucoidan exhibits several pharmacological activities and is characterized by high safety and the absence of toxic side effects. However, the absorption of fucoidan is not well-characterized.
Xu Bai, E Zhang, Bo Hu, Hao Liang, Shuliang Song, Aiguo Ji   +5 more
doaj   +1 more source

Ebulin l Is Internalized in Cells by Both Clathrin-Dependent and -Independent Mechanisms and Does Not Require Clathrin or Dynamin for Intoxication

Toxins, 2021
Ebulin l is an A-B toxin, and despite the presence of a B chain, this toxin displays much less toxicity to cells than the potent A-B toxin ricin. Here, we studied the binding, mechanisms of endocytosis, and intracellular pathway followed by ebulin l and ...
Rosario Iglesias, José M. Ferreras, Alicia Llorente, Lucía Citores   +3 more
doaj   +1 more source

Human Coronavirus 229E Uses Clathrin-Mediated Endocytosis as a Route of Entry in Huh-7 Cells

Biomolecules
Human coronavirus 229E (HCoV-229E) is an endemic coronavirus responsible for approximately one-third of “common cold” cases. To infect target cells, HCoV-229E first binds to its receptor on the cell surface and then can follow different pathways ...
Sabina Andreu, Inés Ripa, José Antonio López-Guerrero, Raquel Bello-Morales   +3 more
doaj   +1 more source

Synaptic vesicles are primed for fast clathrin-mediated endocytosis at the ribbon synapse

Frontiers in Molecular Neuroscience, 2014
Retrieval of synaptic vesicles can occur 1-10 s after fusion, but the role of clathrin during this process has been unclear because the classical mode of clathrin-mediated endocytosis (CME) is an order of magnitude slower, as during retrieval of surface ...
Ilaria ePelassa, Ilaria ePelassa, CongJian eZhao, CongJian eZhao, Mathias ePasche, Benjamin eOdermatt, Benjamin eOdermatt, Leon eLagnado, Leon eLagnado   +8 more
doaj   +1 more source