Results 1 to 10 of about 115,227 (298)

Dynamics of the formation of flat clathrin lattices in response to growth factor stimulus. [PDF]

PLoS Computational Biology
Clathrin assemblies on the cell membrane are critical for endocytosis and signal transduction in cells. Specifically, the Ω-shaped clathrin assembly functions as the coat of endocytic vesicles, while the flat clathrin assembly, also known as the flat ...
Lingxia Qiao, Marco A Alfonzo-Méndez, Justin W Taraska, Padmini Rangamani   +3 more
doaj   +2 more sources

Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks [PDF]

Nature Communications
Clathrin-mediated endocytosis is essential for membrane traffic, impacting a diverse range of cellular processes including cell signaling homeostasis, cell adhesion, and receptor recycling.
Brandon T. Malady, Andromachi Papagiannoula, Advika Kamatar, Susovan Sarkar, Gavin T. Lebrun, Liping Wang, Carl C. Hayden, Eileen M. Lafer, David J. Owen, Sigrid Milles, Jeanne C. Stachowiak   +10 more
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A CIE change in our understanding of endocytic mechanisms

Frontiers in Cell and Developmental Biology, 2023
The past six decades have seen major advances in our understanding of endocytosis, ranging from descriptive studies based on electron microscopy to biochemical and genetic characterization of factors required for vesicle formation.
Daniel J. Rioux, Daniel J. Rioux, Derek C. Prosser   +2 more
doaj   +1 more source

A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly. [PDF]

PLoS ONE, 2016
The clathrin heavy chain N-terminal domain interacts with endocytic adapter proteins via clathrin binding motifs to assemble clathrin triskelia into cages. However, the precise mechanism of clathrin assembly is not yet known.
Lia Moshkanbaryans, Jing Xue, Jesse Ray Wark, Phillip James Robinson, Mark Evan Graham   +4 more
doaj   +1 more source

Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses

eLife, 2022
At postsynaptic sites of neurons, a prominent clathrin-coated structure, the endocytic zone (EZ), controls the trafficking of glutamate receptors and is essential for synaptic plasticity.
Lisa AE Catsburg, Manon Westra, Annemarie ML van Schaik, Harold D MacGillavry   +3 more
doaj   +1 more source

Effects of the clathrin inhibitor Pitstop-2 on synaptic vesicle recycling at a central synapse in vivo

Frontiers in Synaptic Neuroscience, 2022
Four modes of endocytosis and subsequent synaptic vesicle (SV) recycling have been described at the presynapse to ensure the availability of SVs for synaptic release.
Alp Paksoy, Simone Hoppe, Yvette Dörflinger, Heinz Horstmann, Kurt Sätzler, Christoph Körber   +5 more
doaj   +1 more source

Host Factors Genes BcCLC1 and BcCLC2 Confer Turnip Mosaic Virus Resistance in Non-Heading Chinese Cabbage (Brassica campestris ssp. chinensis)

Plants, 2023
Clathrin is an evolutionarily highly conserved evolutionary protein consisting of clathrin light chains (CLC) and clathrin heavy chains (CHC), and these form its basic structure. Clathrin is an important host factor in the process of viral infection.
Mengguo Yuan, Shanwu Lyu, Yaolong Wang, Liu E, Tongkun Liu, Xilin Hou, Ying Li, Changwei Zhang   +7 more
doaj   +1 more source

Pitstop‐2 and its novel derivative RVD‐127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPases

Bioengineering & Translational Medicine, 2023
Clathrin‐mediated endocytosis (CME) is an essential cell physiological process of broad biomedical relevance. Since the recent introduction of Pitstop‐2 as a potent CME inhibitor, we and others have reported on substantial clathrin‐independent inhibitory
Ivan Liashkovich, Sílvio Terra Stefanello, Reshma Vidyadharan, Günter Haufe, Alexander Erofeev, Peter V. Gorelkin, Vasilii Kolmogorov, Caren Rigon Mizdal, Alexander Dulebo, Etmar Bulk, Ian U. Kouzel, Victor Shahin   +11 more
doaj   +1 more source

Characterization of a temperature-sensitive vertebrate clathrin heavy chain mutant as a tool to study clathrin-dependent events in vivo.

PLoS ONE, 2010
Clathrin and clathrin-dependent events are evolutionary conserved although it is believed that there are differences in the requirement for clathrin in yeast and higher vertebrates. Clathrin is a long-lived protein and thus, with clathrin knockdowns only
Petra Neumann-Staubitz, Stephanie L Hall, Joseph Kuo, Antony P Jackson   +3 more
doaj   +1 more source

Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies

Journal of Extracellular Vesicles, 2020
Pregnancy is a unique situation, in which placenta-derived small extracellular vesicles (sEVs) may communicate with maternal and foetal tissues. While relevant to homoeostatic and pathological functions, the mechanisms underlying sEV entry and cargo ...
Hui Li, Itziar Pinilla-Macua, Yingshi Ouyang, Elena Sadovsky, Kazuhiro Kajiwara, Alexander Sorkin, Yoel Sadovsky   +6 more
doaj   +1 more source