Membrane Heterogeneity Controls Cellular Endocytic Trafficking
Frontiers in Cell and Developmental Biology, 2020 Endocytic trafficking relies on highly localized events in cell membranes. Endocytosis involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations defined by specific lipid and protein compositions.
Gregory M. I. Redpath +7 more
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A role for amphiphysin in AP-1/clathrin coat formation [PDF]
, 2013 Transport of cargo within the endocytic and secretory pathway is generally mediated by coated vesicles. Clathrin, in combination with different adaptor proteins, is the major coat protein for vesicle formation at the plasma membrane, endosomes, and the ...
Huser Studer, Sonja
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Clathrin-independent pathways do not contribute significantly to endocytic flux
eLife, 2014 Several different endocytic pathways have been proposed to function in mammalian cells. Clathrin-coated pits are well defined, but the identity, mechanism and function of alternative pathways have been controversial.
Vassilis Bitsikas +2 more
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Recruitment of AP-1 clathrin adaptors to liposomal membranes [PDF]
, 2004 Protein and membrane traffic between organelles within the endocytic and exocytic pathway is mediated most prominently by coated vesicles. These vesicles are formed by the assembly of cytosolic coat proteins onto the donor membrane, which deform it into ...
Meyer, Daniel Markus
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An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy [PDF]
, 2012 Current knowledge of the structural changes taking place during clathrin-mediated endocytosis is largely based on electron microscopy images of fixed preparations and x-ray crystallography data of purified proteins.
Merrifield, C.J. +40 more
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The ∼ 16 kDa C-terminal sequence of clathrin assembly protein AP180 is essential for efficient clathrin binding. [PDF]
PLoS ONE, 2014 Brain-specific AP180 is present in clathrin coats at equal concentration to the adapter complex, AP2, and assembles clathrin faster than any other protein in vitro.
Ling-Shan Chan +3 more
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A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin [PDF]
, 2011 An essential stage in endocytic coated vesicle recycling is the dissociation of clathrin from the vesicle coat by the molecular chaperone, Hsc70 and the J-domain-containing protein, auxilin, in an ATP-dependent process.
Petr Kuzmic +14 more
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A cytosolic factor mediating membrane recruitment of AP-1 clathrin adaptors [PDF]
, 2008 Transport of cargo within the endocytic and secretory pathway is generally mediated by coated vesicles. These vesicles are formed through the recruitment of cytosolic coat proteins to the donor membrane that act as a scaffold to form coated buds and ...
Suri, Gregor
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TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation [PDF]
, 2015 The interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved.
Cristina Gutiérrez-Caballero +11 more
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Clathrin-Inspired Coating and Stabilization of Liposomes by DNA Self-Assembly [PDF]
, 2019 The self-assembly of the protein clathrin on biological membranes facilitates essential processes of endocytosis in biological systems and has provided a source of inspiration for materials design by the highly ordered structural appearance. By mimicking
Diana Sobota (6944451) +6 more
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