Results 21 to 30 of about 64,892 (258)

Brain clathrin and clathrin-associated proteins. [PDF]

Biochemical Journal, 1982
The assembly of clathrin into baskets or cages in vitro may depend on formation of complex between clathrin and a polypeptide doublet migrating in the 30000-mol.wt. region. Clathrin with several associated proteins was isolated from coated-vesicle fractions of bovine cerebral cortex.
M P, Lisanti, W, Schook, N, Moskowitz, C, Ores, S, Puszkin   +4 more
openaire   +2 more sources

Characterization of a temperature-sensitive vertebrate clathrin heavy chain mutant as a tool to study clathrin-dependent events in vivo.

PLoS ONE, 2010
Clathrin and clathrin-dependent events are evolutionary conserved although it is believed that there are differences in the requirement for clathrin in yeast and higher vertebrates. Clathrin is a long-lived protein and thus, with clathrin knockdowns only
Petra Neumann-Staubitz, Stephanie L Hall, Joseph Kuo, Antony P Jackson   +3 more
doaj   +1 more source

Pitstop‐2 and its novel derivative RVD‐127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPases

Bioengineering & Translational Medicine, 2023
Clathrin‐mediated endocytosis (CME) is an essential cell physiological process of broad biomedical relevance. Since the recent introduction of Pitstop‐2 as a potent CME inhibitor, we and others have reported on substantial clathrin‐independent inhibitory
Ivan Liashkovich, Sílvio Terra Stefanello, Reshma Vidyadharan, Günter Haufe, Alexander Erofeev, Peter V. Gorelkin, Vasilii Kolmogorov, Caren Rigon Mizdal, Alexander Dulebo, Etmar Bulk, Ian U. Kouzel, Victor Shahin   +11 more
doaj   +1 more source

ROLE OF CERAMIDE IN TRANSFERRIN RECEPTOR MOVEMENT IN THE PLANE OF THE PLASMA MEMBRANE [PDF]

Assiut Veterinary Medical Journal, 2010
After ligation with transferrin (Tf), transferrin receptor (TfR) is aggregated on cell surface in clathrin coated pits and then internalized into the cell.
RANA ALAWADHI, A-B.M. ABDEL-SHAKOR
doaj   +1 more source

Clathrin is spindle-associated but not essential for mitosis.

PLoS ONE, 2008
BackgroundClathrin is a multimeric protein involved in vesicle coat assembly. Recently clathrin distribution was reported to change during the cell cycle and was found to associate with the mitotic spindle.
Joana Borlido, Greg Veltri, Antony P Jackson, Ian G Mills   +3 more
doaj   +1 more source

Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies

Journal of Extracellular Vesicles, 2020
Pregnancy is a unique situation, in which placenta-derived small extracellular vesicles (sEVs) may communicate with maternal and foetal tissues. While relevant to homoeostatic and pathological functions, the mechanisms underlying sEV entry and cargo ...
Hui Li, Itziar Pinilla-Macua, Yingshi Ouyang, Elena Sadovsky, Kazuhiro Kajiwara, Alexander Sorkin, Yoel Sadovsky   +6 more
doaj   +1 more source

Membrane Heterogeneity Controls Cellular Endocytic Trafficking

Frontiers in Cell and Developmental Biology, 2020
Endocytic trafficking relies on highly localized events in cell membranes. Endocytosis involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations defined by specific lipid and protein compositions.
Gregory M. I. Redpath, Gregory M. I. Redpath, Verena M. Betzler, Verena M. Betzler, Pascal Rossatti, Pascal Rossatti, Jérémie Rossy, Jérémie Rossy   +7 more
doaj   +1 more source

The ∼ 16 kDa C-terminal sequence of clathrin assembly protein AP180 is essential for efficient clathrin binding. [PDF]

PLoS ONE, 2014
Brain-specific AP180 is present in clathrin coats at equal concentration to the adapter complex, AP2, and assembles clathrin faster than any other protein in vitro.
Ling-Shan Chan, Lia Moshkanbaryans, Jing Xue, Mark E Graham   +3 more
doaj   +1 more source

Clathrin-independent pathways do not contribute significantly to endocytic flux

eLife, 2014
Several different endocytic pathways have been proposed to function in mammalian cells. Clathrin-coated pits are well defined, but the identity, mechanism and function of alternative pathways have been controversial.
Vassilis Bitsikas, Ivan R Corrêa Jr, Benjamin J Nichols   +2 more
doaj   +1 more source

Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles [PDF]

Science Advances, 2020
Cryo-electron tomography reveals the conformational changes and clathrin interactions of AP2 during coated vesicle assembly.
Kovtun, Oleksiy, Kane Dickson, Veronica, Kelly, Bernard T., Owen, David. J., Briggs, John A. G.   +4 more
openaire   +4 more sources