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Clathrin is an evolutionarily highly conserved evolutionary protein consisting of clathrin light chains (CLC) and clathrin heavy chains (CHC), and these form its basic structure. Clathrin is an important host factor in the process of viral infection.
Mengguo Yuan +7 more
doaj +1 more source
Clathrin Adaptor GGA1 Polymerizes Clathrin into Tubules [PDF]
GGAs, a class of monomeric clathrin adaptors, are involved in the sorting of cargo at the trans-Golgi network of eukaryotic cells. They are modular structures consisting of the VHS, the GAT, hinge, and GAE domains, which have been shown to interact directly with cargo, ARF, clathrin, and accessory proteins, respectively.
Fang, Zhang +5 more
openaire +2 more sources
Brain clathrin and clathrin-associated proteins. [PDF]
The assembly of clathrin into baskets or cages in vitro may depend on formation of complex between clathrin and a polypeptide doublet migrating in the 30000-mol.wt. region. Clathrin with several associated proteins was isolated from coated-vesicle fractions of bovine cerebral cortex.
M P, Lisanti +4 more
openaire +2 more sources
Clathrin-independent, cholesterol and dynamin-dependent uptake of B19V in MDCK II cells. [PDF]
MDCK II cells grown on TC inserts were pre-treated for 30 min with drugs interfering with clathrin, caveolae-mediated endocytosis, and dynamin function, and infected with B19V at pH 6.1.
Corinne Suter (15853142) +5 more
core +1 more source
Clathrin‐mediated endocytosis (CME) is an essential cell physiological process of broad biomedical relevance. Since the recent introduction of Pitstop‐2 as a potent CME inhibitor, we and others have reported on substantial clathrin‐independent inhibitory
Ivan Liashkovich +11 more
doaj +1 more source
Hsc70-induced changes in clathrin-auxilin cage structure suggest a role for clathrin light chains in cage disassembly [PDF]
The molecular chaperone, Hsc70, together with its co-factor, auxilin, facilitates the ATP-dependent removal of clathrin during clathrin-mediated endocytosis in cells.
Brodsky, Frances M. +14 more
core +1 more source
ROLE OF CERAMIDE IN TRANSFERRIN RECEPTOR MOVEMENT IN THE PLANE OF THE PLASMA MEMBRANE [PDF]
After ligation with transferrin (Tf), transferrin receptor (TfR) is aggregated on cell surface in clathrin coated pits and then internalized into the cell.
RANA ALAWADHI, A-B.M. ABDEL-SHAKOR
doaj +1 more source
Non-specificity of Pitstop 2 in clathrin-mediated endocytosis [PDF]
Small molecule inhibitors of clathrin-mediated endocytosis are highly desired for the dissection of membrane trafficking pathways in the lab and for potential use as anti-infectives in the clinic.
Willox, Anna K. +5 more
core +1 more source
Clathrin and clathrin-dependent events are evolutionary conserved although it is believed that there are differences in the requirement for clathrin in yeast and higher vertebrates. Clathrin is a long-lived protein and thus, with clathrin knockdowns only
Petra Neumann-Staubitz +3 more
doaj +1 more source
Pregnancy is a unique situation, in which placenta-derived small extracellular vesicles (sEVs) may communicate with maternal and foetal tissues. While relevant to homoeostatic and pathological functions, the mechanisms underlying sEV entry and cargo ...
Hui Li +6 more
doaj +1 more source

