Results 11 to 20 of about 80,290 (296)
Dynamics of Intracellular Clathrin/AP1- and Clathrin/AP3-Containing Carriers [PDF]
Cell Reports, 2012 Clathrin/AP1- and clathrin/AP3-coated vesicular carriers originate from endosomes and the trans-Golgi network. Here, we report the real-time visualization of these structures in living cells reliably tracked by rapid, three-dimensional imaging with the ...
Comert Kural +6 more
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American Journal of Physiology-Cell Physiology, 2000 Subconfluent cultures of Madin-Darby canine kidney (MDCK) and CV-1 cells were immunostained with two monoclonal antibodies (MAbs), MAb X-22 and MAb 23, against clathrin heavy chain and with polyclonal antiserum against a conserved region of all mammalian clathrin light chains.
C T, Okamoto, J, McKinney, Y Y, Jeng
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Clathrin Independent Endocytosis
, 2016 The existence of endocytic pathways that do not rely on the coat protein clathrin have been known for some time. However, until recently the mechanisms involved in these pathways, as well as their functions, cargoes, and dynamics were largely unknown. Recent advances are leading to a new understanding of the magnitude of clathrin-independent pathways ...
Parton, R. G., R.G. Parton
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LRRC4 Orchestrates AP2A1-Containing Clathrin-Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression. [PDF]
Adv Sci (Weinh)LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Li Y +5 more
europepmc +2 more sources
Clathrin exchange during clathrin-mediated endocytosis [PDF]
The Journal of Cell Biology, 2001 During clathrin-mediated endocytosis, clathrin-coated pits invaginate to form clathrin-coated vesicles (CVs). Since clathrin-coated pits are planar structures, whereas CVs are spherical, there must be a structural rearrangement of clathrin as invagination occurs.
Wu, Xufeng +5 more
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Clathrin Adaptor GGA1 Polymerizes Clathrin into Tubules [PDF]
Journal of Biological Chemistry, 2007 GGAs, a class of monomeric clathrin adaptors, are involved in the sorting of cargo at the trans-Golgi network of eukaryotic cells. They are modular structures consisting of the VHS, the GAT, hinge, and GAE domains, which have been shown to interact directly with cargo, ARF, clathrin, and accessory proteins, respectively.
Fang, Zhang +5 more
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Brain clathrin and clathrin-associated proteins. [PDF]
Biochemical Journal, 1982 The assembly of clathrin into baskets or cages in vitro may depend on formation of complex between clathrin and a polypeptide doublet migrating in the 30000-mol.wt. region. Clathrin with several associated proteins was isolated from coated-vesicle fractions of bovine cerebral cortex.
M P, Lisanti +4 more
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Hsc70-induced changes in clathrin-auxilin cage structure suggest a role for clathrin light chains in cage disassembly [PDF]
, 2013 The molecular chaperone, Hsc70, together with its co-factor, auxilin, facilitates the ATP-dependent removal of clathrin during clathrin-mediated endocytosis in cells.
Brodsky, Frances M. +14 more
core +1 more source
Non-specificity of Pitstop 2 in clathrin-mediated endocytosis [PDF]
, 2014 Small molecule inhibitors of clathrin-mediated endocytosis are highly desired for the dissection of membrane trafficking pathways in the lab and for potential use as anti-infectives in the clinic.
Willox, Anna K. +5 more
core +1 more source
Clathrin-independent pathways do not contribute significantly to endocytic flux
eLife, 2014 Several different endocytic pathways have been proposed to function in mammalian cells. Clathrin-coated pits are well defined, but the identity, mechanism and function of alternative pathways have been controversial.
Vassilis Bitsikas +2 more
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