Dynamics of Intracellular Clathrin/AP1- and Clathrin/AP3-Containing Carriers
Cell Reports, 2012 Clathrin/AP1- and clathrin/AP3-coated vesicular carriers originate from endosomes and the trans-Golgi network. Here, we report the real-time visualization of these structures in living cells reliably tracked by rapid, three-dimensional imaging with the ...
Comert Kural +6 more
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The role of clathrin in post-golgi trafficking in toxoplasma gondii [PDF]
, 2013 Apicomplexan parasites are single eukaryotic cells with a highly polarised secretory system that contains unique secretory organelles (micronemes and rhoptries) that are required for host cell invasion.
Ferguson, D.J.P. +3 more
core +14 more sources
Clathrin exchange during clathrin-mediated endocytosis [PDF]
The Journal of Cell Biology, 2001 During clathrin-mediated endocytosis, clathrin-coated pits invaginate to form clathrin-coated vesicles (CVs). Since clathrin-coated pits are planar structures, whereas CVs are spherical, there must be a structural rearrangement of clathrin as invagination occurs.
Wu, Xufeng +5 more
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Clathrin Adaptor GGA1 Polymerizes Clathrin into Tubules [PDF]
Journal of Biological Chemistry, 2007 GGAs, a class of monomeric clathrin adaptors, are involved in the sorting of cargo at the trans-Golgi network of eukaryotic cells. They are modular structures consisting of the VHS, the GAT, hinge, and GAE domains, which have been shown to interact directly with cargo, ARF, clathrin, and accessory proteins, respectively.
Fang, Zhang +5 more
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Hsc70-induced changes in clathrin-auxilin cage structure suggest a role for clathrin light chains in cage disassembly [PDF]
, 2013 The molecular chaperone, Hsc70, together with its co-factor, auxilin, facilitates the ATP-dependent removal of clathrin during clathrin-mediated endocytosis in cells.
Brodsky, Frances M. +10 more
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Clathrin Senses Membrane Curvature [PDF]
Biophysical Journal, 2020 ABSTRACTThe ability of proteins to sense membrane curvature is essential to diverse membrane remodeling processes including clathrin-mediated endocytosis. Multiple adaptor proteins within the clathrin pathway have been shown to assemble together at curved membrane sites, leading to local recruitment of the clathrin coat.
Wade F, Zeno +7 more
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Membrane Heterogeneity Controls Cellular Endocytic Trafficking
Frontiers in Cell and Developmental Biology, 2020 Endocytic trafficking relies on highly localized events in cell membranes. Endocytosis involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations defined by specific lipid and protein compositions.
Gregory M. I. Redpath +7 more
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Clathrin-independent pathways do not contribute significantly to endocytic flux
eLife, 2014 Several different endocytic pathways have been proposed to function in mammalian cells. Clathrin-coated pits are well defined, but the identity, mechanism and function of alternative pathways have been controversial.
Vassilis Bitsikas +2 more
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Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. [PDF]
, 2012 Clathrin coat accessory proteins play key roles in transport mediated by clathrin-coated vesicles. Yeast Irc6p and the related mammalian p34 are putative clathrin accessory proteins that interact with clathrin adaptor complexes.
Cascio, Duilio +5 more
core +1 more source
Nanobody-dependent delocalization of endocytic machinery in Arabidopsis root cells dampens their internalization capacity [PDF]
, 2020 Plant cells perceive and adapt to an ever-changing environment by modifying their plasma membrane (PM) proteome. Whereas secretion deposits new integral membrane proteins, internalization by endocytosis removes membrane proteins and associated ligands ...
De Meyer, Andreas +4 more
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