Results 41 to 50 of about 64,892 (258)

The cellular functions of clathrin [PDF]

Cellular and Molecular Life Sciences, 2006
Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking.
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Clathrin: the molecular shape shifter

Biochemical Journal, 2021
Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also participates to a diverse range of cellular functions. Key to this is clathrin's ability to assemble into polyhedral lattices that include curved football or basket shapes, flat lattices or even tubular structures.
Katherine M. Wood, Corinne J. Smith
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Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
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The Ins and Outs of Antigen Uptake in B cells

Frontiers in Immunology, 2022
A review of our current knowledge of B cell antigen uptake mechanisms, the relevance of these processes to pathology, and outstanding questions in the field.
Adam Nathan McShane, Dessislava Malinova
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Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy

International Journal of Nanomedicine, 2020
Xiaowei Wang, Yuhan Qiu, Mengyan Wang, Conghui Zhang, Tianshu Zhang, Huimin Zhou, Wenxia Zhao, Wuli Zhao, Guimin Xia, Rongguang Shao Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing ...
Wang X, Qiu Y, Wang M, Zhang C, Zhang T, Zhou H, Zhao W, Zhao W, Xia G, Shao R   +9 more
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Clathrin facilitates the morphogenesis of retrovirus particles.

PLoS Pathogens, 2011
The morphogenesis of retroviral particles is driven by Gag and GagPol proteins that provide the major structural component and enzymatic activities required for particle assembly and maturation.
Fengwen Zhang, Trinity Zang, Sam J Wilson, Marc C Johnson, Paul D Bieniasz   +4 more
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Characterization of Zika Virus Endocytic Pathways in Human Glioblastoma Cells

Frontiers in Microbiology, 2020
Zika virus (ZIKV) infections can cause microcephaly and neurological disorders. However, the early infection events of ZIKV in neural cells remain to be characterized. Here, by using a combination of pharmacological and molecular approaches and the human
Mei Li, Mei Li, Di Zhang, Di Zhang, Chuntian Li, Chuntian Li, Zifeng Zheng, Zifeng Zheng, Ming Fu, Ming Fu, Fengfeng Ni, Fengfeng Ni, Yalan Liu, Tao Du, Hanzhong Wang, George E. Griffin, Mudan Zhang, Qinxue Hu, Qinxue Hu   +18 more
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Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Clathrin‐independent internalization and recycling [PDF]

Journal of Cellular and Molecular Medicine, 2007
Introduction Clathrin‐dependent internalization Clathrin‐independent internalization Macropinocytosis Caveolae‐dependent internalization Clathrin‐and‐caveolae‐independent internalization Pericentrion, a novel PKC‐dependent recycling endosomal structure Clathrin‐independent pathways in neuronal cells Summary AbstractThe functionality of receptor and ...
Gong, Qiang, Huntsman, Christopher, Ma, Dzwokai   +2 more
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