Results 51 to 60 of about 75,443 (301)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Human Coronavirus 229E Uses Clathrin-Mediated Endocytosis as a Route of Entry in Huh-7 Cells
BiomoleculesHuman coronavirus 229E (HCoV-229E) is an endemic coronavirus responsible for approximately one-third of “common cold” cases. To infect target cells, HCoV-229E first binds to its receptor on the cell surface and then can follow different pathways ...
Sabina Andreu +3 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 Endocytosis is a process essential to the health and well-being of cell. It is required for the internalisation and sorting of “cargo”—the macromolecules, proteins, receptors and lipids of cell signalling.
Kate L. Prichard +4 more
doaj +1 more source
Clathrin Senses Membrane Curvature [PDF]
Biophysical Journal, 2020 ABSTRACT The ability of proteins to sense membrane curvature is essential to diverse membrane remodeling processes including clathrin-mediated endocytosis. Multiple adaptor proteins within the clathrin pathway have been shown to assemble together at curved membrane sites, leading to local recruitment of the clathrin coat.
Wade F, Zeno +7 more
openaire +4 more sources
Clathrin-dependent endocytosis is involved in RHDV internalization and is regulated by NCL. [PDF]
, 2018 (A) Clathrin-dependent endocytosis is involved in RHDV internalization. RK-13 cells of three groups were pretreated with CPZ (30 mM), EIPA (50 mM), or Nys (100 mM) for 2 h. Another group of cells was transfected with NCL siRNA (100 nM) for 24 h.
Xiaoxue Wang (311457) +8 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Molecular Cancer, 2013 Background During metaphase clathrin stabilises the mitotic spindle kinetochore(K)-fibres. Many anti-mitotic compounds target microtubule dynamics.
Smith Charlotte M +4 more
doaj +1 more source
"In vitro" reconstitution of "trans"-Golgi exit and the effect of GAG attachment on protein sorting [PDF]
, 2007 The trans-Golgi network is one of the main sorting stations for proteins and lipids in the eukaryotic endomembrane system. Yet, the mechanisms for sorting and transport out of the trans-Golgi network remain poorly understood.
Kobialka, Szymon
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Synaptic vesicles are primed for fast clathrin-mediated endocytosis at the ribbon synapse
Frontiers in Molecular Neuroscience, 2014 Retrieval of synaptic vesicles can occur 1-10 s after fusion, but the role of clathrin during this process has been unclear because the classical mode of clathrin-mediated endocytosis (CME) is an order of magnitude slower, as during retrieval of surface ...
Ilaria ePelassa +8 more
doaj +1 more source