Results 71 to 80 of about 75,443 (301)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Ins and Outs of Antigen Uptake in B cells

Frontiers in Immunology, 2022
A review of our current knowledge of B cell antigen uptake mechanisms, the relevance of these processes to pathology, and outstanding questions in the field.
Adam Nathan McShane, Dessislava Malinova
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Characterization of Zika Virus Endocytic Pathways in Human Glioblastoma Cells

Frontiers in Microbiology, 2020
Zika virus (ZIKV) infections can cause microcephaly and neurological disorders. However, the early infection events of ZIKV in neural cells remain to be characterized. Here, by using a combination of pharmacological and molecular approaches and the human
Mei Li, Mei Li, Di Zhang, Di Zhang, Chuntian Li, Chuntian Li, Zifeng Zheng, Zifeng Zheng, Ming Fu, Ming Fu, Fengfeng Ni, Fengfeng Ni, Yalan Liu, Tao Du, Hanzhong Wang, George E. Griffin, Mudan Zhang, Qinxue Hu, Qinxue Hu   +18 more
doaj   +1 more source

Clathrin‐independent internalization and recycling [PDF]

Journal of Cellular and Molecular Medicine, 2007
Introduction Clathrin‐dependent internalization Clathrin‐independent internalization Macropinocytosis Caveolae‐dependent internalization Clathrin‐and‐caveolae‐independent internalization Pericentrion, a novel PKC‐dependent recycling endosomal structure Clathrin‐independent pathways in neuronal cells Summary AbstractThe functionality of receptor and ...
Gong, Qiang, Huntsman, Christopher, Ma, Dzwokai   +2 more
openaire   +2 more sources

Endocytosis of the ASGP receptor H1 is reduced by mutation of tyrosine-5 but still occurs via coated pits [PDF]

, 1991
The clustering of plasma membrane receptors in clathrin-coated pits depends on determinants within their cytoplasmic domains. In several cases, individual tyrosine residues were shown to be necessary for rapid internalization.
Geffen, I, M Spiess, Spiess, M, Fuhrer, C., C Fuhrer, Spiess, M., I Geffen, Geffen, I., Fuhrer, Christian; https://orcid.org/   +8 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Clathrin modulates vesicle scission, but not invagination shape, in yeast endocytosis

eLife, 2016
In a previous paper (Picco et al., 2015), the dynamic architecture of the protein machinery during clathrin-mediated endocytosis was visualized using a new live imaging and particle tracking method. Here, by combining this approach with correlative light
Wanda Kukulski, Andrea Picco, Tanja Specht, John AG Briggs, Marko Kaksonen   +4 more
doaj   +1 more source

Characterization of anti‐clathrin serum [PDF]

FEBS Letters, 1978
Coated vesicles (CVs), membrane bilayers enclosed by polygonal protein lattices, are ubiquitous cellular organelles which are involved in a variety of membrane transfer processes [l-S]. Recently, Pearse has isolated CVs from several different mammalian tissues [6,7]. They contain a major protein component, clathrin, a mol.
Fine, Richard E., Blitz, Alan L., Sack, David H.   +2 more
openaire   +2 more sources

Architecture of coatomer: Molecular characterization of delta-COP and protein interactions within the complex [PDF]

, 1996
Copyright © 2011 by The Rockefeller University Press.Coatomer is a cytosolic protein complex that forms the coat of COP I-coated transport vesicles.
Faulstich, D, S Wegchingel, S Auerbach, L Orci, F T Wieland, Wegehingel, S, Ravazzola, M, Auerbach, S, Harter, C, H Tschochner, Stenbeck, G, Lottspeich, F, Wegchingel, S, F Lottspeich, Orci, L, G Stenbeck, Tschochner, H, D Faulstich, C Harter, M Ravazzola, Wieland, FT   +20 more
core   +1 more source