Results 71 to 80 of about 80,290 (296)

Architecture of coatomer: Molecular characterization of delta-COP and protein interactions within the complex [PDF]

, 1996
Copyright © 2011 by The Rockefeller University Press.Coatomer is a cytosolic protein complex that forms the coat of COP I-coated transport vesicles.
Faulstich, D, S Wegchingel, S Auerbach, L Orci, F T Wieland, Wegehingel, S, Ravazzola, M, Auerbach, S, Harter, C, H Tschochner, Stenbeck, G, Lottspeich, F, Wegchingel, S, F Lottspeich, Orci, L, G Stenbeck, Tschochner, H, D Faulstich, C Harter, M Ravazzola, Wieland, FT   +20 more
core   +1 more source

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source

Sprouty2 Regulates Endocytosis and Degradation of Fibroblast Growth Factor Receptor 1 in Glioblastoma Cells

Cells
The Sprouty (SPRY) proteins are evolutionary conserved modulators of receptor tyrosine kinase (RTK) signaling. SPRY2 inhibits fibroblast growth factor (FGF) signaling, whereas it enhances epidermal growth factor (EGF) signaling through inhibition of EGF ...
Barbara Hausott, Lena Pircher, Michaela Kind, Jong-Whi Park, Peter Claus, Petra Obexer, Lars Klimaschewski   +6 more
doaj   +1 more source

Clathrin‐independent internalization and recycling [PDF]

Journal of Cellular and Molecular Medicine, 2007
Introduction Clathrin‐dependent internalization Clathrin‐independent internalization Macropinocytosis Caveolae‐dependent internalization Clathrin‐and‐caveolae‐independent internalization Pericentrion, a novel PKC‐dependent recycling endosomal structure Clathrin‐independent pathways in neuronal cells Summary AbstractThe functionality of receptor and ...
Gong, Qiang, Huntsman, Christopher, Ma, Dzwokai   +2 more
openaire   +2 more sources

Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag‐ATMP Translation

Advanced Healthcare Materials, EarlyView.
Magnetically responsive nanoparticles enable remote control over biomaterials, cells, and engineered tissues. This review summarizes material design, biological safety, fabrication and actuation strategies, computational validation, and translational pathways that support the development of magnetic tissue‐engineering platforms and future magnetically ...
Konstantinos Ioannidis, Dimitrios Lefas, Maya Guilliams, Jackie Van Grootenbril, Isaak Decoene, Dimitrios Sakellariou, Bart Smeets, Stefanos Mourdikoudis, Ioannis Papantoniou   +8 more
wiley   +1 more source

Novel clathrin activity: developments in health and disease

Biomolecular Concepts, 2014
Clathrin self-assembles into a coat around vesicles filled with cargo such as nutrients, hormones, and proteins destined for degradation. Recent developments indicate clathrin is not a specialist, but is involved in different processes relevant to health
Ybe Joel A.
doaj   +1 more source

Clathrin modulates vesicle scission, but not invagination shape, in yeast endocytosis

eLife, 2016
In a previous paper (Picco et al., 2015), the dynamic architecture of the protein machinery during clathrin-mediated endocytosis was visualized using a new live imaging and particle tracking method. Here, by combining this approach with correlative light
Wanda Kukulski, Andrea Picco, Tanja Specht, John AG Briggs, Marko Kaksonen   +4 more
doaj   +1 more source

17β-Estradiol Inhibits PCSK9-Mediated LDLR Degradation Through GPER/PLC Activation in HepG2 Cells

Frontiers in Endocrinology, 2020
Plasma levels of PCSK9 are significantly higher in postmenopausal women. Pharmacologically increased estrogen levels have been shown to lower PCSK9 and LDL-C levels in animals and humans. The action of estrogen suggests that it has the ability to prevent
Wei Fu, Xiao-Ping Gao, Sheng Zhang, Yan-Ping Dai, Wen-Jun Zou, Li-Min Yue   +5 more
doaj   +1 more source

Clathrin-dependent endocytosis is associated with RNAi response in the western corn rootworm, Diabrotica virgifera virgifera LeConte [PDF]

, 2018
The cellular uptake of dsRNA after dietary exposure is critical for RNAi efficiency; however, the mechanism of its uptake in many insects remains to be understood. In this study, we evaluated the roles of the endocytic pathway genes Clathrin heavy chain (
Newton P. Carneiro (224355), Kenneth E. Narva (290522), Siegfried, Blair D., Ana M. Vélez (5617253), Haichuan Wang (362568), Haichuan Wang, Fishilevich, Elane, Kenneth E Narva, WANG, H., Carneiro, Newton P., Narva, Kenneth E., Arnubio Valencia-Jiménez (549329), Pinheiro, Daniele H., Velez, Ana Maria, Ana M Vélez, Elane Fishilevich, Arnubio Valencia-Jiménez, VALENCIA-JIMÉNEZ, A., Velez, Ana M., SIEGFRIED, B. D., Newton P Carneiro, PINHEIRO, D. H., Valicente, Fernando H., VALICENTE, F. H., Wang, Haichuan, Blair D Siegfried, NARVA, E. K., Fernando H. Valicente (405988), FISHILEVICH, E., CARNEIRO, N. P., VÉLEZ, A. M., Blair D. Siegfried (208322), Fernando H Valicente, Valencia-Jimenez, Arnubio, Daniele H. Pinheiro (5617250), Elane Fishilevich (709413), Daniele H Pinheiro   +36 more
core   +2 more sources

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source