Results 91 to 100 of about 115,227 (298)

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Fowl adenovirus serotype 4 enters leghorn male hepatocellular cells via the clathrin-mediated endocytosis pathway

Veterinary Research, 2023
Hepatitis-hydropericardium syndrome (HHS) induced by fowl adenovirus serotype-4 (FAdV-4) has caused large economic losses to the world poultry industry in recent years.
Ting Wang, Lizhen Wang, Wei Li, Xiaolan Hou, Wenchi Chang, Bo Wen, Shuizhong Han, Yan Chen, Xuefeng Qi, Jingyu Wang   +9 more
doaj   +1 more source

Cargo regulates clathrin-coated pit invagination via clathrin light chain phosphorylation [PDF]

Journal of Cell Biology, 2018
Clathrin light chains (CLCs) control selective uptake of a range of G protein–coupled receptors (GPCRs), although the mechanism by which this occurs has remained elusive thus far. In particular, site-specific phosphorylation of CLCb controls the uptake of the purinergic GPCR P2Y12, but it is dispensable for the constitutive uptake of the transferrin ...
Hannes Maib, Filipe Ferreira, Stéphane Vassilopoulos, Elizabeth Smythe   +3 more
openaire   +4 more sources

Investigation of microsphere-mediated cellular delivery by chemical, microscopic and gene expression analysis [PDF]

, 2010
Amino functionalised cross-linked polystyrene microspheres of well defined sizes (0.2-2 mm) have been prepared and shown to be efficient and controllable delivery devices, capable of transporting anything from small dye molecules to bulky proteins into ...
Akhtar, Alessandra Livigni, Alexander, Baldacchino, Banerji, Bernheim, Betz, Boschetti, Bradley, Brodsky, Cherukuri, Du, Díaz-Mochón, Grimmer, Hall, Joshua M. Brickman, Kilsdonk, Liu, Lois M. Alexander, Mark Bradley, Mosiman, Murray, Nabel, Orlandi, Pantarotto, Parnham, Pelkmans, Pernagallo, Puri, Rejman, Rosario M. Sánchez-Martín, Salvatore Pernagallo, Sandvig, Schmid, Shin, Silverstein, Slomkowski, Spiegelberg, Subramanian, Sánchez-Martín, Sánchez-Martín, Sánchez-Martín, Trollinger, Tsukihara, Van Dam, Wang, Wheeler, Wörle-Knirsch, Zauner, Ziauddin, Zuhorn   +50 more
core   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Clathrin Heavy Chain Knockdown Impacts CXCR4 Signaling and Post-translational Modification

Frontiers in Cell and Developmental Biology, 2019
Recent research has implicated endocytic pathways as important regulators of receptor signaling. However, the role of endocytosis in regulating chemokine CXC receptor 4 (CXCR4) signaling remains largely unknown.
Maxwell S. DeNies, Luciana K. Rosselli-Murai, Santiago Schnell, Santiago Schnell, Santiago Schnell, Allen P. Liu, Allen P. Liu, Allen P. Liu, Allen P. Liu   +8 more
doaj   +1 more source

Clathrin‐independent internalization and recycling [PDF]

Journal of Cellular and Molecular Medicine, 2007
Introduction Clathrin‐dependent internalization Clathrin‐independent internalization Macropinocytosis Caveolae‐dependent internalization Clathrin‐and‐caveolae‐independent internalization Pericentrion, a novel PKC‐dependent recycling endosomal structure Clathrin‐independent pathways in neuronal cells Summary AbstractThe functionality of receptor and ...
Gong, Qiang, Huntsman, Christopher, Ma, Dzwokai   +2 more
openaire   +2 more sources

The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen presenting cells [PDF]

, 2012
The C-type lectin DC-SIGN expressed on dendritic cells (DCs) facilitates capture and internalization of a plethora of different pathogens. Although it is known that DC-SIGN organizes in nanoclusters at the surface of DCs, the molecular mechanisms ...
Alvarez, Ashby, Bakker, Banchereau, Bonifaz, Cambi, Cambi, Cambi, Cambi, Cambi, Chung, de Bakker, de Witte, Feinberg, Feinberg, Gaborski, Geijtenbeek, Geijtenbeek, Geijtenbeek, Geijtenbeek, Gringhuis, Itano, Itano, Khoo, Koopman, Liu, Liu, Lozach, Lozach, Ludwig, Menon, Mitchell, Neumann, Pohlmann, Puig-Kröger, Rappocciolo, Regan, Serrano-Gómez, Sierra-Filardi, Simmons, Smith, Soilleux, Steinman, Tacken, Tacken, Théry, Trombetta, van Kooyk, Yu, Zhu   +49 more
core   +5 more sources