Results 61 to 70 of about 75,443 (301)

Study on Absorption Mechanism and Tissue Distribution of Fucoidan

Molecules, 2020
Fucoidan exhibits several pharmacological activities and is characterized by high safety and the absence of toxic side effects. However, the absorption of fucoidan is not well-characterized.
Xu Bai, E Zhang, Bo Hu, Hao Liang, Shuliang Song, Aiguo Ji   +5 more
doaj   +1 more source

Ebulin l Is Internalized in Cells by Both Clathrin-Dependent and -Independent Mechanisms and Does Not Require Clathrin or Dynamin for Intoxication

Toxins, 2021
Ebulin l is an A-B toxin, and despite the presence of a B chain, this toxin displays much less toxicity to cells than the potent A-B toxin ricin. Here, we studied the binding, mechanisms of endocytosis, and intracellular pathway followed by ebulin l and ...
Rosario Iglesias, José M. Ferreras, Alicia Llorente, Lucía Citores   +3 more
doaj   +1 more source

Conformation Switching of Clathrin Light Chain Regulates Clathrin Lattice Assembly [PDF]

, 2010
SummaryClathrin-coated vesicle formation is responsible for membrane traffic to and from the endocytic pathway during receptor-mediated endocytosis and organelle biogenesis, influencing how cells relate to their environment.
Wilbur, Jeremy D., Brodsky, Frances M., Fletterick, Robert J., Hwang, Peter K., Ybe, Joel A., Lane, Michael, Jacobson, Matthew P., Sellers, Benjamin D.   +7 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy

International Journal of Nanomedicine, 2020
Xiaowei Wang, Yuhan Qiu, Mengyan Wang, Conghui Zhang, Tianshu Zhang, Huimin Zhou, Wenxia Zhao, Wuli Zhao, Guimin Xia, Rongguang Shao Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing ...
Wang X, Qiu Y, Wang M, Zhang C, Zhang T, Zhou H, Zhao W, Zhao W, Xia G, Shao R   +9 more
doaj  

The cellular functions of clathrin [PDF]

Cellular and Molecular Life Sciences, 2006
Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking.
openaire   +2 more sources

Clathrin: the molecular shape shifter

Biochemical Journal, 2021
Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also participates to a diverse range of cellular functions. Key to this is clathrin's ability to assemble into polyhedral lattices that include curved football or basket shapes, flat lattices or even tubular structures.
Katherine M. Wood, Corinne J. Smith
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Clathrin facilitates the morphogenesis of retrovirus particles.

PLoS Pathogens, 2011
The morphogenesis of retroviral particles is driven by Gag and GagPol proteins that provide the major structural component and enzymatic activities required for particle assembly and maturation.
Fengwen Zhang, Trinity Zang, Sam J Wilson, Marc C Johnson, Paul D Bieniasz   +4 more
doaj   +1 more source

Clathrin-dependent endocytosis is associated with RNAi response in the western corn rootworm, Diabrotica virgifera virgifera LeConte [PDF]

, 2018
The cellular uptake of dsRNA after dietary exposure is critical for RNAi efficiency; however, the mechanism of its uptake in many insects remains to be understood. In this study, we evaluated the roles of the endocytic pathway genes Clathrin heavy chain (
Newton P. Carneiro (224355), Kenneth E. Narva (290522), Siegfried, Blair D., Ana M. Vélez (5617253), Haichuan Wang (362568), Haichuan Wang, Fishilevich, Elane, Kenneth E Narva, WANG, H., Carneiro, Newton P., Narva, Kenneth E., Arnubio Valencia-Jiménez (549329), Pinheiro, Daniele H., Velez, Ana Maria, Ana M Vélez, Elane Fishilevich, Arnubio Valencia-Jiménez, VALENCIA-JIMÉNEZ, A., Velez, Ana M., SIEGFRIED, B. D., Newton P Carneiro, PINHEIRO, D. H., Valicente, Fernando H., VALICENTE, F. H., Wang, Haichuan, Blair D Siegfried, NARVA, E. K., Fernando H. Valicente (405988), FISHILEVICH, E., CARNEIRO, N. P., VÉLEZ, A. M., Blair D. Siegfried (208322), Fernando H Valicente, Valencia-Jimenez, Arnubio, Daniele H. Pinheiro (5617250), Elane Fishilevich (709413), Daniele H Pinheiro   +36 more
core   +2 more sources