Results 51 to 60 of about 113,399 (298)
Endomembrane-Based Signaling by GPCRs and G-Proteins
Cells, 2022 G-protein-coupled receptors (GPCRs) and G-proteins have a range of roles in many physiological and pathological processes and are among the most studied signaling proteins. A plethora of extracellular stimuli can activate the GPCR and can elicit distinct
Federica Liccardo +2 more
doaj +1 more source
FERARI and cargo adaptors coordinate cargo flow through sorting endosomes [PDF]
, 2021 Cellular organization, compartmentalization and cell-to-cell communication are crucially dependent on endosomal pathways. Sorting endosomes provide a transit point for various trafficking pathways and decide the fate of proteins: recycling, secretion or ...
Solinger, Jachen A. +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Participation of Endosomes in Toll-Like Receptor 3 Transportation Pathway in Murine Astrocytes
Frontiers in Cellular Neuroscience, 2020 TLR3 provides immediate type I IFN response following entry of stimulatory PAMPs into the CNS, as it is in HSV infection. The receptor plays a vital role in astrocytes, contributing to rapid infection sensing and suppression of viral replication ...
Matylda B. Mielcarska +11 more
doaj +1 more source
Transport at the recycling endosome [PDF]
Current Opinion in Cell Biology, 2010 The recycling endosome (RE) has long been considered as a sub-compartment of the early endosome that recycles internalized cargoes to the plasma membrane. The RE is now appreciated to participate in a more complex set of intracellular itineraries. Key cargo molecules and transport factors that act in these pathways are being identified.
Victor W, Hsu, Rytis, Prekeris
openaire +2 more sources
Analysis of the role or Rab4 and Rab11 in endosomal carrier formation and transferrin recycling [PDF]
, 2012 : In all eukaryotic cells, membrane transport is essential to distribute proteins from the endoplasmic reticulum to their respective destination, i.e. the Golgi, the endosomal/lysosomal system and the cell exterior. A multitude of proteins is involved in
Hirschmann, David
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Magnetic control of membrane damage in early endosomes using internalized magnetic nanoparticles
Cell Structure and FunctionMembrane stiffness is essential for cell migration, tumorigenesis, and development; however, the physical properties of intracellular membrane are poorly characterized.
Yuta Yonekawa +11 more
doaj +1 more source
A Role of Phosphatidylserine in the Function of Recycling Endosomes
Frontiers in Cell and Developmental Biology, 2021 Cells internalize proteins and lipids in the plasma membrane (PM) and solutes in the extracellular space by endocytosis. The removal of PM by endocytosis is constantly balanced by the replenishment of proteins and lipids to PM through recycling pathway ...
Junya Hasegawa +5 more
doaj +1 more source