Results 31 to 40 of about 39,562,488 (191)

Cannabidiol sensitizes TRPV2 channels to activation by 2-APB

eLife, 2023
The cation-permeable TRPV2 channel is important for cardiac and immune cell function. Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance, is one of the few molecules known to activate TRPV2.
Aaron Gochman, Xiao-Feng Tan, Chanhyung Bae, Helen Chen, Kenton J Swartz, Andres Jara-Oseguera   +5 more
doaj   +1 more source

Identification of putative potassium channel homologues in pathogenic protozoa [PDF]

, 2012
K(+) channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms.
Prole, D L, Neil V Marrion, Marrion, NV, David L Prole   +3 more
core   +2 more sources

Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+ Currents in Isolated Lysosomes [PDF]

Journal of Biological Chemistry, 2010
Two-pore channels (TPCNs) have been proposed to form lysosomal Ca(2+) release channels that are activated by nicotinic acid adenine dinucleotide phosphate. Here, we employ a glass chip-based method to record for the first time nicotinic acid adenine dinucleotide phosphate -dependent currents through a two-pore channel (TPCN2) from intact lysosomes.
Michael, Schieder, Katrin, Rötzer, Andrea, Brüggemann, Martin, Biel, Christian A, Wahl-Schott   +4 more
openaire   +2 more sources

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]

, 2012
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Szalontai, B., Ötvös, Ferenc, Benyhe, S., Boyett, M., Vágvölgyi, Csaba, Szûts, V., Papp, J.G., Dobrzynski, H.; id_orcid, Szüts, Viktória, Dézsi, László, Szalontai, Balázs, Dobrzynski, Halina, Zhang, Henggui, Benyhe, Sándor, Dézsi, L., Varró, András, Boyett, Marc, Vágvölgyi, C., Varró, A., Ötvös, F., Zhang, H., Papp, Gyula, Erdélyi, L., Erdélyi, Lajos   +23 more
core   +2 more sources

The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection

Cells, 2021
The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases ...
Antonella D’Amore, Antonella Gradogna, Fioretta Palombi, Velia Minicozzi, Matteo Ceccarelli, Armando Carpaneto, Antonio Filippini   +6 more
doaj   +1 more source

KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel α-subunit composition [PDF]

, 2011
Voltage-gated potassium (Kv) currents generated by N-type α-subunit homotetramers inactivate rapidly because an N-terminal ball domain blocks the channel pore after activation.
Abbott, G., Xu, Xianghua, Geoffrey W. Abbott, Kanda, Vikram A, Abbott, Geoffrey W, Anthony Lewis, Vikram A. Kanda, Xianghua Xu, Lewis, Anthony, Kanda, Vikram A., Xianghua, X., Kanda, V., Abbott, Geoffrey W.   +12 more
core   +1 more source

Enhancement effects of martentoxin on glioma BK channel and BK channel (α+β1) subtypes. [PDF]

PLoS ONE, 2011
BACKGROUND: BK channels are usually activated by membrane depolarization and cytoplasmic Ca(2+). Especially,the activity of BK channel (α+β4) can be modulated by martentoxin, a 37 residues peptide, with Ca(2+)-dependent manner.
Jie Tao, Jian Shi, Li Yan, Ying Chen, Yan Hong Duan, Pin Ye, Qi Feng, Jian Wei Zhang, Xue Qin Shu, Yong Hua Ji   +9 more
doaj   +1 more source

Deficiency of two-pore segment channel 2 contributes to systemic lupus erythematosus via regulation of apoptosis and cell cycle

Chinese Medical Journal, 2022
. Background:. Systemic lupus erythematosus (SLE) is a complex autoimmune disease, and the mechanism of SLE is yet to be fully elucidated. The aim of this study was to explore the role of two-pore segment channel 2 (TPCN2) in SLE pathogenesis.
Keke Li, Jingkai Xu, Ke Xue, Ruixing Yu, Chengxu Li, Wenmin Fei, Xiaoli Ning, Yang Han, Ziyi Wang, Jun Shu, Yong Cui, Lishao Guo   +11 more
doaj   +1 more source

Two-pore channel 2 (TPC2) modulates store-operated Ca2+ entry

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012
Two-pore channels (TCPS) are NAADP-sensitive receptor channels that conduct Ca(2+) efflux from the intracellular stores. Discharge of the internal Ca(2+) pools results in the activation of store-operated Ca(2+) entry (SOCE); however, the role of TPCs in the modulation of SOCE remains unexplored.
López, José J., Dionisio, Natalia, Berna-Erro, Alejandro, Galán, Carmen, Salido, Ginés M., Rosado, Juan A.   +5 more
openaire   +2 more sources

Transport of Ca²⁺ and Ca²⁺-Dependent Permeability Transition in the Liver and Heart Mitochondria of Rats with Different Tolerance to Acute Hypoxia

Biomolecules, 2020
The work examines the kinetic parameters of Ca2+ uptake via the mitochondrial calcium uniporter complex (MCUC) and the opening of the Ca2+-dependent permeability transition pore (MPT pore) in the liver and heart mitochondria of rats with high resistance (
Konstantin N. Belosludtsev, Mikhail V. Dubinin, Eugeny Yu. Talanov, Vlada S. Starinets, Kirill S. Tenkov, Nadezhda M. Zakharova, Natalia V. Belosludtseva   +6 more
doaj   +1 more source