Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations [PDF]
, 2010 CFTR, the ABC protein defective in cystic fibrosis, functions as an anion channel. Once phosphorylated by protein kinase A, a CFTR channel is opened and closed by events at its two cytosolic nucleotide binding domains (NBDs).
Gadsby, David C. +5 more
core +1 more source
The name tells the story: Two-pore channels. [PDF]
, 2020 TPC2-A1-N and TPC2-A1-P, two novel small molecules, differentially activate two-pore channel 2 (TPC2) and mimic the activation of TPC2 with NAADP and PIP2, resulting in distinct ion channel selectivities.
Reymond, Jean-Louis +3 more
core +1 more source
Applied SciencesUnderstanding pore-scale interactions among CO2, the aqueous phase, and heavy oil is crucial for optimizing surfactant-assisted CO2-enhanced oil recovery. In this study, a three-phase volume-of-fluid (VOF) framework is established in OpenFOAM to simulate
Lilong Yang +3 more
doaj +1 more source
Cell-Based Modeling of Tissue Developing in the Scaffold Pores of Varying Cross-Sections
Biomimetics, 2023 In this work, we present a mathematical model of cell growth in the pores of a perfusion bioreactor through which a nutrient solution is pumped.
Ivan Krasnyakov, Dmitry Bratsun
doaj +1 more source
The role of two-pore channels 2 (TPC2) in melanoma tumourigenesis and metastasis
, 2022 Melanoma is an exceedingly aggressive and resistant to treatment form of cancer. Therefore, the identification of novel therapeutic approaches continues to be a crucial task. Understanding the pathophysiological role of potential drug targets for this disease enables the discovery of new therapeutic strategies.
openaire +2 more sources
Two-pore channels provide insight into the evolution of voltage-gated Ca 2+ and Na + channels [PDF]
Science Signaling, 2014 Molecular modeling, pharmacology, and comparative genomics reveal secrets of ion channel evolution.
Taufiq, Rahman +5 more
openaire +2 more sources
Molecules, 2021 Mitochondria play a key role in energy metabolism within the cell. Potassium channels such as ATP-sensitive, voltage-gated or large-conductance Ca2+-regulated channels have been described in the inner mitochondrial membrane.
Aleksandra Sek +4 more
doaj +1 more source
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels [PDF]
Pflügers Archiv - European Journal of Physiology, 2009 In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP).
Galione, Antony +6 more
openaire +3 more sources
Reactive/Adsorptive transport in (partially-) saturated porous media: from pore scale to core scale [PDF]
, 2011 Pore-scale modeling provides opportunities to study transport phenomena in fundamental ways because detailed information is available at the microscopic pore scale. This offers the best hope for bridging the traditional gap that exists between pore scale
Raoof, A. +2 more
core +1 more source
Two-Pore Domain Potassium Channels as Drug Targets: Anesthesia and Beyond.
, 2021 Two-pore domain potassium (K2P) channels stabilize the resting membrane potential of both excitable and nonexcitable cells and, as such, are important regulators of cell activity.
Veale, E.L. +4 more
core +1 more source