Electro-steric opening of the clc-2 chloride channel gate
Scientific Reports, 2021 The widely expressed two-pore homodimeric inward rectifier CLC-2 chloride channel regulates transepithelial chloride transport, extracellular chloride homeostasis, and neuronal excitability.
José J. De Jesús-Pérez +8 more
doaj +1 more source
Vicia faba SV channel VfTPC1 is a hyperexcitable variant of plant vacuole Two Pore Channels
eLife, 2023 To fire action-potential-like electrical signals, the vacuole membrane requires the two-pore channel TPC1, formerly called SV channel. The TPC1/SV channel functions as a depolarization-stimulated, non-selective cation channel that is inhibited by luminal
Jinping Lu +11 more
doaj +1 more source
mTORC1 controls lysosomal Ca 2+ release through the two-pore channel TPC2 [PDF]
Science Signaling, 2018 The ion channel TPC2 is required for Ca 2+ mobilization from lysosomes in response to mTORC1 inhibition and to NAADP.
Oluseye A. Ogunbayo +7 more
openaire +2 more sources
Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms
Nature CommunicationsPannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Nazia Hussain +7 more
doaj +1 more source
Variable Assembly of EMRE and MCU Creates Functional Channels with Distinct Gatekeeping Profiles
iScience, 2020 Summary: MCU is a Ca2+-selective channel that mediates mitochondrial Ca2+ influx. The human channel contains tetrameric pore-forming MCU, regulatory subunits MICU1/2, and EMRE that is required both for channel function and MICU1/2-mediated Ca2 ...
Riley Payne, Carmen Li, J. Kevin Foskett
doaj +1 more source
The Role of Lipids in CRAC Channel Function
Biomolecules, 2022 The composition and dynamics of the lipid membrane define the physical properties of the bilayer and consequently affect the function of the incorporated membrane transporters, which also applies for the prominent Ca2+ release-activated Ca2+ ion channel (
Lena Maltan +2 more
doaj +1 more source
Properties of single two‐pore domain TREK‐2 channels expressed in mammalian cells
The Journal of Physiology, 2007 TREK‐2 (K2P10.1), a member of the two‐pore domain K+ (K2P) channel family, provides the background K+ conductance in many cell types, and is a target of neurotransmitters that act on receptors coupled to Gs and Gq. We report here that TREK‐2 exhibits small (TREK‐2S) and large (TREK‐2L) conductance phenotypes when expressed in mammalian cell lines (COS ...
Dawon, Kang +3 more
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A two-pressure model for slightly compressible single phase flow in bi-structured porous media [PDF]
, 2012 Problems involving flow in porous media are ubiquitous in many natural and engineered systems. Mathematical modeling of such systems often relies on homogenization of pore-scale equations and macroscale continuum descriptions.
Davit, Yohan +5 more
core +1 more source
Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel. [PDF]
PLoS ONE, 2016 GLIC receptor is a bacterial pentameric ligand-gated ion channel whose action is inhibited by xenon. Xenon has been used in clinical practice as a potent gaseous anaesthetic for decades, but the molecular mechanism of interactions with its integral ...
Ludovic Sauguet +4 more
doaj +1 more source
Yield stress fluids method to determine the pore size distribution of a porous medium [PDF]
, 2014 In this paper a new method is presented in order to determine the pore size distribution in a porous medium. This original technique uses the rheological properties of some non-Newtonian yield stress fluids flowing through the porous sample.
AMBARI, Abdelhak +2 more
core +1 more source