Results 91 to 100 of about 39,562,488 (191)

Natural channel protein inserts and functions in a completely artificial, solid-supported bilayer membrane [PDF]

, 2013
Reconstitution of membrane proteins in artificial membrane systems creates a platform for exploring their potential for pharmacological or biotechnological applications.
Fu, Wangyang, Palivan, Cornelia G., Meier, Wolfgang, Zhang, Xiaoyan   +3 more
core   +1 more source

Using a New Finite Slit Pore Model for NLDFT Analysis of Carbon Pore Structure

Adsorption Science & Technology, 2011
In this work, we present a model for analyzing activated carbon micropore structures based on graphene sheet walls of finite thickness and extent. This is a two-dimensional modification of the widely used infinite slit pore model that assumes graphite ...
Jacek Jagiello, Jeffrey Kenvin, James P. Olivier, Andrew R. Lupini, Cristian I. Contescu   +4 more
doaj   +1 more source

Interaction of fatty acids and phospholipids with multiple binding sites on the potassium channel KcsA

, 2011
The majority of lipids that interact with a transmembrane protein act as a solvent for the protein, forming a shell around it; these lipids are called annular or boundary lipids.
Bolivar Gonzalez, Juan
core   +1 more source

Selective Small Molecule Activators of TREK‑2 Channels Stimulate Dorsal Root Ganglion c‑Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx

, 2016
The two-pore-domain potassium (K2P) channel TREK-2 serves to modulate plasma membrane potential in dorsal root ganglia c-fiber nociceptors, which tunes electrical excitability and nociception.
C. David Weaver (655503), Emily Days (655502), Paige N. Vinson (1671460), Nicholas C. Vierra (3358286), Prasanna K. Dadi (3358283), Matthew T. Dickerson (3358280), David A. Jacobson (150112)   +6 more
core   +1 more source

Insights into the structure and modulation of human TWIK-2

Nature Communications
The Tandem of pore domain in a Weak Inward Rectifying K+ channel 2 (TWIK-2; KCNK6) is a member of the Two-Pore Domain K + (K2P) channel family, which is associated with pulmonary hypertension, lung injury, and inflammation.
Qianqian Ma, Ciria C. Hernandez, Vikas Navratna, Arvind Kumar, Jaimin K. Rana, Jiameng Zong, Abraham Lee, Shyamal Mosalaganti   +7 more
doaj   +1 more source

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR. [PDF]

, 2013
A central step in the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the association of its two cytosolic nucleotide-binding domains (NBDs) into a head-to-tail dimer, with two nucleotides bound at the ...
Mihályi Csaba, Vergani P, Töröcsik, B, Csanády, László, Csanády László, Mihályi, C, Csaba Mihályi, Paola Vergani, Vergani, Paola, Beáta Töröcsik, Szollosi, A, László Csanády, Szőllősi, András, Szöllősi András, Törőcsik, Beáta, Mihályi, Csaba, Andras Szollosi, Vergani, P, Törőcsik Beáta, Csanády, L   +19 more
core   +1 more source

The structure of a voltage gated potassium channel

, 2010
Voltage gated potassium channels (Kv channels) are tetrameric ion channels, responsible for regulating the potassium component of the membrane potential in a large range of cell types ranging from mammalian excitable cells to bacteria. Attempts have been
Rogers, Nik
core   +1 more source

KUTV news featurette on cloning, molecular genetics, and disease aired November 9, 1997

, 1997
videoThis 3 minutes, 1 second video clip from Salt Lake City\u27s KUTV, Channel 2 features a short interview with Mario Capecchi concerning cloning and its use in molecular genetics and the study of human ...
KUTV, Channel 2
core  

N-glycosylation-dependent control of functional expression of background potassium channels K2P3.1 and K2P9.1

, 2013
Two-pore domain potassium (K2P) channels play fundamental roles in cellular processes by enabling a constitutive leak of potassium from cells in which they are expressed, thus influencing cellular membrane potential and activity.
Roncoroni, Laura, Lowry, Eleanor, Johnson, Daniel, O'Kelly, Ita, Williams, Sarah, Mant, Alexandra   +5 more
core   +1 more source

K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect [PDF]

, 2002
Background— Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.
Hubank, M, Stephanou, A., Chanalaris, A., Townsend, P. A., Lawrence, K. M., Townsend, P A, Lawrence, KM, Knight, RA, Ferrari, R., Chanalaris, A, Scarabelli, T., Scarabelli, T, Hubank, M., Pasini, E., Townsend, PA, Latchman, D S, Tinker, A., Latchman, D. S., Knight, R A, Pasini, E, Comini, L, Lawrence, K M, Latchman, DS, Tinker, A, Ferrari, R, Comini, L., Knight, R. A., Stephanou, A   +27 more
core   +1 more source