Results 111 to 120 of about 39,562,488 (191)

Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell [PDF]

, 1999
The potassium M current was originally identified in sympathetic ganglion cells, and analogous currents have been reported in some central neurons and also in some neural cell lines.
Abogadie, FC, Wood, IC, London, B, Buckley, NJ, Brown, DA, Hadley, JK, Delmas, P, Selyanko, AA   +7 more
core  

Molecular details of ruthenium red pore block in TRPV channels

EMBO Reports
Transient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal pore blocker for a wide array
Ruth A Pumroy, José J De Jesús-Pérez, Anna D Protopopova, Julia A Rocereta, Edwin C Fluck, Tabea Fricke, Bo-Hyun Lee, Tibor Rohacs, Andreas Leffler, Vera Moiseenkova-Bell   +9 more
doaj   +1 more source

Single-channel behavior of heteromeric α1β glycine receptors: an attempt to detect a conformational change before the channel opens [PDF]

, 2004
The α1β heteromeric receptors are likely to be the predominant synaptic form of glycine receptors in the adult. Their activation mechanism was investigated by fitting putative mechanisms to single-channel recordings obtained at four glycine ...
Burzomato, V., Beato, M., Colquhoun, D., Groot-Kormelink, P.J., Sivilotti, L.G.   +4 more
core  

Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH. [PDF]

J Biol Chem, 2017
Lu YY, Hao BX, Graeff R, Wong CWM, Wu WT, Yue J.   +5 more
europepmc   +1 more source

Characterization of mouse two-pore channels (TPCs) in NAADP-mediated Ca(2+) signalling

, 2011
Recent studies have identified Two-Pore Channels (TPCs) as the channels activated by NAADP. To date, most studies that characterized these channels have employed heterologous expression or overexpression systems. The research reported here has focused principally on endogenous TPC activity by using single and dual gene knockout (KO) in a mouse system ...
openaire   +1 more source

Inhibition of endolysosomal two-pore channel 2 (TPC2) induces osteoblast differentiation and matrix mineralization while targeting autophagy. [PDF]

J Endocrinol Invest
Montaseri A, Rossi M, Battafarano G, Riccioli A, Palombi F, Giampietri C, Liguoro D, Mancini R, Meucci M, Palmisano B, Riminucci M, Keller M, Bracher F, Grimm C, Umehara K, De-Eknamkul W, Filippini A, Del Fattore A.   +17 more
europepmc   +1 more source

Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC. [PDF]

Front Immunol
Ouologuem L, Kübler A, Ouologuem S, Hadzic A, Stöckl JB, Siciliano AC, Forciniti S, Nigro S, Iuele H, Onesto V, Nguyen A, Matzek D, Abrahamian C, Grimm C, Popper B, Gigli G, Del Mercato LL, Merkel OM, Fröhlich T, Theurich S, Bartel K.   +20 more
europepmc   +1 more source

Two-pore channel 2 is required for soluble adenylyl cyclase-dependent regulation of melanosomal pH and melanin synthesis. [PDF]

Pigment Cell Melanoma Res
Zhou D, Eraslan Z, Miller D, Taylor I, You J, Grondin SJ, Vega M, Manga P, Goff PS, Sviderskaya EV, Gross SS, Chen Q, Zippin JH.   +12 more
europepmc   +1 more source

Efect of two pore domain potassium channel

, 2006
The aim of this Project is to do a research in the nerve system of the Lymnaea Stagnalis specifically the study of the 2-Pore domain potassium channel in order to find its mammalian counterpart. To be able to make a comparison between the snail's channel
Martínez Vega, Diana del Pilar
core  

Naringenin impairs two-pore channel 2 2ctivity and inhibits vegf-induced angiogenesis

, 2017
Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by electrophysiological evidence in a heterologous system, i.e. Arabidopsis vacuoles lacking endogenous TPCs.
Pafumi, Irene, Festa, Margherita, Papacci, Francesca, Lagostena, Laura, Giunta, Cristina, Gutla, Vijay, Cornara, Laura, Favia, Annarita, Palombi, Fioretta, Gambale, Franco, Filippini, Antonio, Carpaneto, Armando   +11 more
openaire   +1 more source