Results 41 to 50 of about 1,799 (138)

Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells

Frontiers in Cell and Developmental Biology, 2022
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered second messenger that gates two pore channels 1 (TPC1) and 2 (TPC2) to elicit endo-lysosomal (EL) Ca2+ release.
Pawan Faris, Claudio Casali, Sharon Negri, Lara Iengo, Marco Biggiogera, Angela Serena Maione, Francesco Moccia   +6 more
doaj   +1 more source

Electrophysiology of Endolysosomal Two-Pore Channels: A Current Account

Cells, 2022
Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically relevant proteins that reside on endolysosomal vesicles. Here, we review the electrophysiology of these channels.
Sandip Patel, Yu Yuan, Cheng-Chang Chen, Dawid Jaślan, Gihan Gunaratne, Christian Grimm, Taufiq Rahman, Jonathan S. Marchant   +7 more
doaj   +1 more source

Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma

Biomolecules, 2021
Microphthalmia-associated transcription factor (MITF) is the principal transcription factor regulating pivotal processes in melanoma cell development, growth, survival, proliferation, differentiation and invasion. In recent years, convincing evidence has
Carla Abrahamian, Christian Grimm
doaj   +1 more source

TPC2 knockdown facilitated neural lineage entry of mouse ES cells while overexpression of TPC2 inhibited it.

, 2013
(A) and (B) RNA was harvested at the indicated time points during neural differentiation of scramble shRNA infected, TPC2 knockdown, and TPC2 overexpressing D3 ES cells and analyzed for expression of Sox1 (A) and Nestin (B) by quantitative real-time RT ...
Ying-Ying Lu (420876), Zhe-Hao Zhang (420875), Jianbo Yue (114211)   +2 more
core   +1 more source

Two-pore channels affect EGF receptor signaling by receptor trafficking and expression

iScience, 2021
Summary: Two-pore channels (TPCs) are key components for regulating Ca2+ current from endosomes and lysosomes to the cytosol. This locally restricted Ca2+ current forms the basis for fusion and fission events between endolysosomal membranes and thereby ...
Thomas Müller, Sonja Grossmann, Robert Theodor Mallmann, Carolin Rommel, Lutz Hein, Norbert Klugbauer   +5 more
doaj   +1 more source

Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis

Scientific Reports, 2017
Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by electrophysiological evidence in a heterologous system, i.e. Arabidopsis vacuoles lacking
Irene Pafumi, Margherita Festa, Francesca Papacci, Laura Lagostena, Cristina Giunta, Vijay Gutla, Laura Cornara, Annarita Favia, Fioretta Palombi, Franco Gambale, Antonio Filippini, Armando Carpaneto   +11 more
doaj   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

TPC2 signaling in mouse ES cells.

, 2013
(A) Expressions of TPC2 mRNAs in D3 ES cells were determined by RT-PCR. (B) NAADP-AM induced a Ca2+ increase in TPC2 overexpressing ES cells in a bell-shaped concentration response curve.
Ying-Ying Lu (420876), Zhe-Hao Zhang (420875), Jianbo Yue (114211)   +2 more
core   +1 more source

Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2

FEBS Open Bio, 2022
Cepharanthine (CEP) is a natural biscoclaurine alkaloid of plant origin and was recently demonstrated to have anti‐severe acute respiratory syndrome coronavirus 2 (anti‐SARS‐CoV‐2) activity.
Atsushi Hijikata, Clara Shionyu‐Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Takatsugu Hirokawa, Shogo Nakajima, Koichi Watashi, Tsuyoshi Shirai   +9 more
doaj   +1 more source

Impact of Mammalian Two-Pore Channel Inhibitors on Long-Distance Electrical Signals in the Characean Macroalga Nitellopsis obtusa and the Early Terrestrial Liverwort Marchantia polymorpha

Plants, 2021
Inhibitors of human two-pore channels (TPC1 and TPC2), i.e., verapamil, tetrandrine, and NED-19, are promising medicines used in treatment of serious diseases.
Mateusz Koselski, Vilmantas Pupkis, Kenji Hashimoto, Indre Lapeikaite, Agnieszka Hanaka, Piotr Wasko, Egle Plukaite, Kazuyuki Kuchitsu, Vilma Kisnieriene, Kazimierz Trebacz   +9 more
doaj   +1 more source