Results 61 to 70 of about 1,799 (138)

The ethoxycarbonyl group as both activating and protective group in N-acyl-Pictet–Spengler reactions using methoxystyrenes. A short approach to racemic 1-benzyltetrahydroisoquinoline alkaloids

Beilstein Journal of Organic Chemistry, 2021
We present a systematic investigation on an improved variant of the N-acyl-Pictet–Spengler condensation for the synthesis of 1-benzyltetrahydroisoquinolines, based on our recently published synthesis of N-methylcoclaurine, exemplified by the total ...
Marco Keller, Karl Sauvageot-Witzku, Franz Geisslinger, Nicole Urban, Michael Schaefer, Karin Bartel, Franz Bracher   +6 more
doaj   +1 more source

Alantolactone: A Potential Multitarget Drug candidate for Prevention of SARS-CoV-2 Cell Entry

Journal of Molecular Docking, 2022
The novel strain of coronavirus, SARS-CoV-2, has spread adverse effects on human health with high mortality rates worldwide. SARS-CoV-2 is a severe respiratory disease expressed through positive single stranded RNA enveloped virus.
Erum Zafar, Zainab Ahsan, Muhammad Faisal Maqbool, Aqsa Zaman, Sameena Gul, Amara Maryam, Muhammad Khan, Hafiz Abdullah Shakir, Muhammad Irfan   +8 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca2+ Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium

Advanced Science, Volume 12, Issue 39, October 20, 2025.
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu, Yong‐jian Guo, Yu‐qi Zhu, Hong‐zheng Wang, Hai‐di Wang, Hong‐yu Chen, Yue‐xin Jiang, Hui Li, Hui Hui   +8 more
wiley   +1 more source

Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons

mBio, 2022
Coronavirus disease 2019 (COVID-19) is frequently associated with neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces these effects remains unclear.
Weili Kong, Mauricio Montano, Michael J. Corley, Ekram Helmy, Hirofumi Kobayashi, Martin Kinisu, Rahul Suryawanshi, Xiaoyu Luo, Loic A. Royer, Nadia R. Roan, Melanie Ott, Lishomwa C. Ndhlovu, Warner C. Greene   +12 more
doaj   +1 more source

Autophagy and Cellular Senescence in Alzheimer's Disease: Key Drivers of Neurodegeneration

CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Impaired autophagy in Alzheimer's disease leads to accumulation of amyloid‐β and tau aggregates, while senescent brain cells secrete pro‐inflammatory SASP factors. The interplay between defective clearance and chronic inflammation accelerates neuronal dysfunction and highlights autophagy enhancers and senolytics as promising therapeutic strategies ...
Md Sadique Hussain, Neetu Agrawal, Baby Ilma, Rekha M M, Priya Priyadarshini Nayak, Mandeep Kaur, Anil Khachi, Kavita Goyal, Arcot Rekha, Saurabh Gupta, Gaurav Gupta, Kamal Dua   +11 more
wiley   +1 more source

Loss of two-pore hannel 2 (TPC2) expression increases the metastatic traits of melanoma cells by a mechanism involving the hippo signalling pathway and store-operated calcium entry [PDF]

, 2020
Melanoma is one of the most aggressive and treatment-resistant human cancers. The two-pore channel 2 (TPC2) is located on late endosomes, lysosomes and melanosomes.
Andrea Sacconi, Giovanni Blandino, John Parrington, Hanbashi, Ali Ahmed, Ali Ahmed Hanbashi, Filippini, Antonio, Palombi, Fioretta, Taggi, Marilena, Di Agostino, Silvia, Rita Canipari, Canipari, Rita, Parrington, John, D'Amore, Antonella, Antonio Filippini, Blandino, Giovanni, Silvia Di Agostino, Aniruddha Voruganti, Marilena Taggi, Fioretta Palombi, Antonella D’Amore, Sacconi, Andrea, Voruganti, Aniruddha   +21 more
core   +1 more source

A commentary on the inhibition of human TPC2 channel by the natural flavonoid naringenin: Methods, experiments, and ideas

Biomolecular Concepts, 2023
Human endo-lysosomes possess a class of proteins called TPC channels on their membrane, which are essential for proper cell functioning. This protein family can be functionally studied by expressing them in plant vacuoles.
Minicozzi Velia, Qi Tianwen, Gradogna Antonella, Pozzolini Marina, Milenkovic Stefan, Filippini Antonio, Ceccarelli Matteo, Carpaneto Armando   +7 more
doaj   +1 more source

TPC2 overexpression markedly induced programmed cell death during neural differentiation of mouse ES cells.

, 2013
(A) Live cell number counting of control, TPC2 knockdown, and TPC2 overexpressing D3 cells at indicated time points during neural differentiation. Data are expressed as mean ± S.E. from five independent experiments.
Ying-Ying Lu (420876), Zhe-Hao Zhang (420875), Jianbo Yue (114211)   +2 more
core   +1 more source

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD‐Like Pathology in Mice

Aging Cell, Volume 24, Issue 6, June 2025.
Our study reveals that overactivation of both mTOR complexes through mLST8 in RPE cells triggers AMD‐like pathology and cellular dysfunction. This finding highlights the critical role of balanced mTOR signaling in retinal health and suggests that targeting both complexes could be therapeutic for AMD treatment.
Olivia Chowdhury, Sridhar Bammidi, Pooja Gautam, Vishnu Suresh Babu, Haitao Liu, Peng Shang, Ying Xin, Emma Mahally, Mihir Nemani, Victoria Koontz, Kira Lathrop, Katarzyna M. Kedziora, Jonathan Franks, Ming Sun, Joshua W. Smith, Lauren R. DeVine, Robert N. Cole, Nadezda Stepicheva, Anastasia Strizhakova, Sreya Chattopadhyay, Stacey Hose, Jacob Samuel Zigler Jr., José‐Alain Sahel, Jiang Qian, Prasun Guha, James T. Handa, Sayan Ghosh, Debasish Sinha   +27 more
wiley   +1 more source