Results 81 to 90 of about 1,799 (138)

Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes and the endoplasmic reticulum

Cell Reports
Summary: Lysosomes and the endoplasmic reticulum (ER) are Ca2+ stores mobilized by the second messengers NAADP and IP3, respectively. Here, we establish Ca2+ signals between the two sources as fundamental building blocks that couple local release to ...
Yu Yuan, Vikas Arige, Ryo Saito, Qianru Mu, Gabriela C. Brailoiu, Gustavo J.S. Pereira, Stephen R. Bolsover, Marco Keller, Franz Bracher, Christian Grimm, Eugen Brailoiu, Jonathan S. Marchant, David I. Yule, Sandip Patel   +13 more
doaj   +1 more source

Endolysosomal Cation Channels and Cancer—A Link with Great Potential

Pharmaceuticals, 2018
The endolysosomal system (ES) consists of lysosomes; early, late, and recycling endosomes; and autophagosomes. It is a key regulator not only of macromolecule degradation and recycling, plasma membrane repair, homeostasis, and lipid storage, but also of ...
Christian Grimm, Karin Bartel, Angelika M. Vollmar, Martin Biel   +3 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+ [PDF]

, 2010
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a molecule capable of initiating the release of intracellular Ca2+ required for many essential cellular processes.
Ganesan, A., Grant C. Churchill, Gosain, R, Sitsapesan, Rebecca, Pitt, SJ, Ruas, M, Pitt, Samantha Jane, Antony Galione, Parrington, J, Zhu, Michael X, Sitsapesan, Mano, Zhu, M X, Samantha J. Pitt, Zhu, Michael X., Rajendra Gosain, Venturi, E, Rebecca Sitsapesan, Funnell, TM, Funnell, Tim M., Churchill, Grant, Parrington, John, Elisa Venturi, Churchill, GC, Sitsapesan, R, Katja Rietdorf, Michael X. Zhu, Venturi, Elisa, Sitsapesan, M, Galione, A, Galione, Antony, John Parrington, Rietdorf, K, A. Ganesan, Funnell, T, Churchill, Grant C, Rietdorf, Katja, Reitdorf, K, Mano Sitsapesan, Churchill, Grant C., Zhu, MX, Margarida Ruas, Funnell, Tim M, Pitt, S J, Gosain, Rajendra, Ruas, Margarida, Pitt, Samantha J., Ganesan, A, Churchill, R C, Tim M. Funnell   +48 more
core   +1 more source

Mechanism study on the effect of torrefaction pretreatment on humification and microbial community in straw composting

Industrial Crops and Products
Enhancing the humification and quality of composting is a key research focus in the field of biomass composting. This study developed torrefaction as a pretreatment method for lignocellulosic biomass, coupled with composting, to investigate its effects ...
Cuina Qin, Bingyi Jiang, Lihui Yu, Xirong Huang, Haoteng Zhang, Zhenwen Zhang, Shuo Jiang, Chunjiang Yu   +7 more
doaj   +1 more source

An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

Cell Reports, 2017
Membrane contact sites are regions of close apposition between organelles that facilitate information transfer. Here, we reveal an essential role for Ca2+ derived from the endo-lysosomal system in maintaining contact between endosomes and the endoplasmic
Bethan S. Kilpatrick, Emily R. Eden, Leanne N. Hockey, Elizabeth Yates, Clare E. Futter, Sandip Patel   +5 more
doaj   +1 more source

TPC2 knockdown inhibited neuronal differentiation from mouse ES cells derived neural progenitors.

, 2013
(A) and (B) RNA was harvested at indicated time points during neural differentiation in control and TPC2 knockdown ES cells and analyzed for expression of Mash1 (A) and Nurr1 (B) by qRT-PCR. (C) Immunofluorescent analysis of Tuj1 expression (TujI, Green;
Ying-Ying Lu (420876), Zhe-Hao Zhang (420875), Jianbo Yue (114211)   +2 more
core   +1 more source

Unraveling the potential and complex interplay of endolysosomal proteins TRPML1, TPC2, and Rab7a [PDF]

The endolysosomal network comprises distinct interconnected membrane-bound organelles, namely early endosomes (EEs), recycling endosomes (REs), multivesicular bodies (MVBs), late endosomes (LEs), and lysosomes (LYs). Within eukaryotic cells, LYs serve as
Abrahamian, Carla
core   +1 more source

TPC2 knockdown did not affect glia differentiation of mouse ES cells.

, 2013
(A) and (B) RNA was harvested at indicated time points during neural differentiation and analyzed for expression of GFAP (A) and Olig2 (B) in both control and TPC2 knockdown cells by qRT-PCR.
Ying-Ying Lu (420876), Zhe-Hao Zhang (420875), Jianbo Yue (114211)   +2 more
core   +1 more source

Ca 2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos

, 2017
We recently demonstrated a critical role for two-pore channel type 2 (TPC2)-mediated Ca(2+) release during the differentiation of slow (skeletal) muscle cells (SMC) in intact zebrafish embryos, via the introduction of a translational-blocking morpholino ...
Jeffrey J. Kelu, John Parrington, Webb, SE, Kelu, JJ, Kelu, Jeffrey J., Miller, Andrew L., Parrington, John, Sarah E. Webb, Miller, AL, Antony Galione, Webb, Sarah E., Andrew L. Miller, Galione, Antony   +12 more
core   +1 more source