Results 91 to 100 of about 1,799 (138)

OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage

The Journal of Clinical Investigation
Regulated exocytosis is initiated by increased Ca2+ concentrations in close spatial proximity to secretory granules, which is effectively prevented when the cell is at rest. Here we showed that exocytosis of zymogen granules in acinar cells was driven by
Volodymyr Tsvilovskyy, Roger Ottenheijm, Ulrich Kriebs, Aline Schütz, Kalliope Nina Diakopoulos, Archana Jha, Wolfgang Bildl, Angela Wirth, Julia Böck, Dawid Jaślan, Irene Ferro, Francisco J. Taberner, Olga Kalinina, Staffan Hildebrand, Ulrich Wissenbach, Petra Weissgerber, Dominik Vogt, Carola Eberhagen, Stefanie Mannebach, Michael Berlin, Vladimir Kuryshev, Dagmar Schumacher, Koenraad Philippaert, Juan E. Camacho-Londoño, Ilka Mathar, Christoph Dieterich, Norbert Klugbauer, Martin Biel, Christian Wahl-Schott, Peter Lipp, Veit Flockerzi, Hans Zischka, Hana Algül, Stefan G. Lechner, Marina Lesina, Christian Grimm, Bernd Fakler, Uwe Schulte, Shmuel Muallem, Marc Freichel   +39 more
doaj   +1 more source

Assessing the impact of endolysosomal Two-Pore Channel 2 (TPC2) on human Malignant Melanoma progression

Background: Two-pore channel 2 (TPC2) is a Ca2+/Na+ ion channel located on the membrane of intracellular acidic organelles, including endo-lysosomes and melanosomes. It plays a crucial role in tumor progression across various cancers, including melanoma,
MEUCCI, MARTINA
core  

Endolysosomal two-pore channels regulate a conserved entry pathway for enteroviruses. [PDF]

J Gen Virol
Weng TC, Hsu BY, Wu TH, Gu XY, Cheng HH, Kung SH.   +5 more
europepmc   +1 more source

Inhibition of endolysosomal two-pore channel 2 (TPC2) induces osteoblast differentiation and matrix mineralization while targeting autophagy. [PDF]

J Endocrinol Invest
Montaseri A, Rossi M, Battafarano G, Riccioli A, Palombi F, Giampietri C, Liguoro D, Mancini R, Meucci M, Palmisano B, Riminucci M, Keller M, Bracher F, Grimm C, Umehara K, De-Eknamkul W, Filippini A, Del Fattore A.   +17 more
europepmc   +1 more source

TPC1-dependent control of endosomal pH and transferrin uptake determines cellular iron status. [PDF]

Proc Natl Acad Sci U S A
Deutsch R, Jörs S, Klingl Y, Kudrina V, Menegaz D, Jaślan D, Serianz Z, Vogel A, Abrahamian C, Bhunia S, Tavhelidse-Suck T, Richter C, Wirth A, Urban N, Northoff B, Wilfert W, Klugbauer N, Bracher F, Keller M, Geisler F, Schaefer M, Teupser D, Holdt L, Belkaya S, Freichel M, Grimm C.   +25 more
europepmc   +1 more source

Plant Vacuolar and Human Endolysosomal Two-Pore Channels: Similarities and Differences. [PDF]

Cells
Di Franco E, Milenkovic S, Lagostena L, Meucci M, Festa M, Gradogna A, Dietrich P, Filippini A, Ceccarelli M, Carpaneto A.   +9 more
europepmc   +1 more source

Endosomal TPC1-mediated Ca²⁺ nanodomains regulate transferrin receptor trafficking and iron homeostasis. [PDF]

Proc Natl Acad Sci U S A
Burton WJ, Lin A, Morgan AJ, Davis LC, Chen CC, Galione A.   +5 more
europepmc   +1 more source

Ultrafast reconfigurable topological-modulators-based photonic processing accelerator. [PDF]

Nat Commun
Zhou W, Wang X, Zhang X, Chen Y, Sun M, Jiang Y, Zhang P, Li J, Ni X, Zhu Y, Han Q, Wang J, Yang C, Li B, Qiu F, Tian Y, Su Y, Zhang Y.   +17 more
europepmc   +1 more source

Therapeutic targeting of lysosome-triggered inflammatory channels in nasal and upper-airway allergic conditions. [PDF]

Front Immunol
Yu H, Zheng Y, Wu D, Zhou L, Jiang K, Tian K, Shen N.   +6 more
europepmc   +1 more source

The Two-Pore Channel 2 in Human Physiology and Diseases: Functional Characterisation and Pharmacology. [PDF]

Int J Mol Sci
Lagostena L, Minicozzi V, Meucci M, Gradogna A, Milenkovic S, Palombi F, Ceccarelli M, Filippini A, Carpaneto A.   +8 more
europepmc   +1 more source