Results 71 to 80 of about 1,799 (138)

Tax privacy concerns hamper digitization of the nanostore channel

Decision Sciences, Volume 56, Issue 3, Page 235-253, June 2025.
Abstract Various entities, such as startups, suppliers, and governments, face substantial difficulties in convincing nanostore shopkeepers to adopt digital technologies. Given the informal status of nanostores, we posit that shopkeepers experience Tax Privacy Concerns from their operational records potentially becoming transparent to the tax ...
Rafael Escamilla, Prisca Brosi, Jan C. Fransoo, Camilo Mora‐Quiñones, Christopher Mejía‐Argueta   +4 more
wiley   +1 more source

Deciphering the role of endolysosomal Ca2+ signalling via two-pore channel 2 (TPC2) in cancer: from bench to bedside

, 2023
Cancer is a major public health problem and one of the leading causes of death worldwide, necessitating the development of innovative cancer biomarkers/targets to improve detection, diagnosis, prognosis, and therapy.
Alharbi, Abeer
core   +1 more source

Three‐dimensional geometric morphometric analyses of humerus ecomorphology: New perspectives for paleohabitat reconstruction in carnivorans and ungulates

The Anatomical Record, Volume 308, Issue 3, Page 946-974, March 2025.
Abstract Long bone ecomorphology has proven effective for paleohabitat reconstructions across a wide range of mammalian clades. Still, there is no comprehensive framework to allow interpretation of long bone morphological variation within and between different monophyletic groups.
Carmela Serio, Richard P. Brown, Marcus Clauss, Carlo Meloro   +3 more
wiley   +1 more source

Cytotype and local adaptation drive phenotypic variation in two subspecies of big sagebrush (Artemisia tridentata)

Ecosphere, Volume 16, Issue 3, March 2025.
Abstract Big sagebrush (Artemisia tridentata) is a widespread and locally dominant shrub throughout many ecosystems in western North America. A. tridentata ssps. tridentata and wyomingensis are two subspecies whose populations occupy the warm‐arid regions of the species range and whose trailing edge is threatened by climate change.
Spencer R. Roop, Keith Reinhardt, Ken Aho, Matthew J. Germino, Bryce A. Richardson   +4 more
wiley   +1 more source

Unraveling pH Regulation of TMEM175, an Endolysosomal Cation Channel With a Role in Parkinson's Disease

Journal of Cellular Physiology, Volume 240, Issue 2, February 2025.
ABSTRACT Transmembrane protein 175 (TMEM175) is an endolysosomal cation channel, which has attracted much attention recently from academics and the pharmaceutical industry alike since human mutations in TMEM175 were found to be associated with the development of Parkinson's disease (PD).
Tobias Schulze, Oliver Rauh, Gerhard Thiel, Niels Fertig, Andre Bazzone, Christian Grimm   +5 more
wiley   +1 more source

Morphodynamical adaptation of the endolysosomal system to stress

The FEBS Journal, Volume 292, Issue 2, Page 248-260, January 2025.
Endosomes and lysosomes provide a pivotal interface between intracellular and extracellular compartments and their morphodynamical properties are associated with response to stresses. In this review, we discuss how the endolysosomal system contributes to alleviating homeostatic deviations in cellular response to environmental stress such as nutrients ...
Juliane Da Graça, Cédric Delevoye, Etienne Morel   +2 more
wiley   +1 more source

Nano‐Biointeractions of Functional Nanomaterials: The Emerging Role of Inter‐Organelle Contact Sites, Targeting, and Signaling

Advanced Functional Materials, Volume 34, Issue 52, December 23, 2024.
The cellular uptake of nanomaterials allows them to intracellularly distribute and directly or indirectly interact with cellular organelles. Hence, if appropriately engineered, nanomaterials can modulate organelle activities as well as communication and signaling between different organelles.
Naym Blal, Giuseppe Bardi, Pier Paolo Pompa, Daniela Guarnieri   +3 more
wiley   +1 more source

Investigating the Role of Two-Pore Channel 2 (TPC2) in Zebrafish Neuromuscular Development

, 2020
In this chapter, the authors discuss the techniques used when investigating the role of Two-Pore Channel 2 (TPC2) in zebrafish neuromuscular development.
Sarah E. Webb, Jeffrey J. Kelu, Andrew L. Miller, Webb, Sarah Elizabeth, Kelu, Jeffrey Jenkin, Miller, Andrew Leitch   +5 more
core   +1 more source

Single‐cell transcriptomic atlas of taste papilla aging

Aging Cell, Volume 23, Issue 12, December 2024.
Differentially expressed genes between aged and young taste papillae were identified, including upregulated mt‐Nd4l and Xist, as well as downregulated Hsp90ab1 and Tmem59. Impairing taste receptor cell generation and decreases in expression levels of taste transduction genes were found in the Tmem59−/− circumvallate papillae, and Tmem59−/− mice showed ...
Wenwen Ren, Weihao Li, Xudong Cha, Shenglei Wang, Boyu Cai, Tianyu Wang, Fengzhen Li, Tengfei Li, Yingqi Xie, Zengyi Xu, Zhe Wang, Huanhai Liu, Yiqun Yu   +12 more
wiley   +1 more source

TPC2-mediated Ca²⁺ signaling is required for axon extension in caudal primary motor neurons in zebrafish embryos

, 2020
The role of two-pore channel type 2 (TPC2, encoded by tcpn2)mediated Ca2+ release was recently characterized in zebrafish during establishment of the early spinal circuitry, one of the key events in the coordination of neuromuscular activity.
Guo, Chenxi, Webb, Sarah E., Chan, Ching Man, Miller, Andrew L.   +3 more
core   +1 more source