Results 51 to 60 of about 1,799 (138)
Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions
Traffic, Volume 27, Issue 1, March 2026.Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang +7 more
wiley +1 more source
TPC2 overexpression or knockdown did not affect the self-renewal and pluripotency of mouse ES cells.
, 2013 (A) TPC2 knockdown by two distinctive shRNAs in D3 ES cells was verified by qRT-PCR analysis. (B) Bright field, lysotracker red staining, and GFP cell imaging of the D3 TPC2GFP cell line (Scale bar = 50 µm).
Ying-Ying Lu (420876) +2 more
core +1 more source
Journal of Biomedical Science, 2022 Background Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain. Tauopathy can impair cognitive and motor functions and has been observed in Alzheimer’s disease (AD) and ...
Benjamin Chun-Kit Tong +12 more
doaj +1 more source
IET Energy Systems Integration, Volume 8, Issue 1, January/December 2026.ABSTRACT Against the backdrop of carbon neutrality goals and new power system development, hierarchical distribution‐microgrid systems with three‐port converters (TPCs) have drawn extensive attention. However, existing research on such systems faces three challenges: the ambiguity of carbon potential (CP) at hybrid nodes within TPCs, the intractability
Jian Zhang +3 more
wiley +1 more source
mTORC1 controls lysosomal Ca2+ release through the two-pore channel TPC2 [PDF]
, 2018 Two-pore segment channel 2 (TPC2) is a ubiquitously expressed, lysosomally targeted ion channel that aids in terminating autophagy and is inhibited upon its association with mechanistic target of rapamycin (mTOR).
Duan, Jingxian +15 more
core +1 more source
Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels
eLife, 2019 Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P2-activated, Na+-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the
Xiaoli Zhang +14 more
doaj +1 more source
Neural Plasticity, Volume 2026, Issue 1, 2026.Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age‐related neurodegenerative and neuropsychiatric disorders.
Shaik Basha +7 more
wiley +1 more source
Structural mechanisms of phospholipid activation of the human TPC2 channel
eLife, 2019 Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-activated, Na+ selective channel, in the ligand ...
Ji She +5 more
doaj +1 more source
Contribution of NAADP to Glutamate-Evoked Changes in Ca2+ Homeostasis in Mouse Hippocampal Neurons
Frontiers in Cell and Developmental Biology, 2020 Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that evokes calcium release from intracellular organelles by the engagement of calcium release channels, including members of the Transient Receptor Potential (TRP) family, such ...
Julia Hermann +15 more
doaj +1 more source