Results 31 to 40 of about 1,799 (138)
Small molecule agonist TPC2-A1-N increases intracellular Ca<sup>2+</sup> independent of two-pore channels. [PDF]
J Biol ChemTwo-Pore channels (TPCs) constitute a small family of cation channels expressed in endo-lysosomal compartments. TPCs have been characterized as important constituents controlling Ca2+-mediated vesicular membrane fusion and fission, thereby regulating ...
Mallmann RT +4 more
europepmc +2 more sources
Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells. [PDF]
PLoS ONE, 2013 Nicotinic acid adenine dinucleotide phosphate (NAADP) is an endogenous Ca(2+) mobilizing nucleotide presented in various species. NAADP mobilizes Ca(2+) from acidic organelles through two pore channel 2 (TPC2) in many cell types and it has been ...
Zhe-Hao Zhang, Ying-Ying Lu, Jianbo Yue
doaj +1 more source
Cancer Cell International, 2023 Background Melanoma, a severe form of skin cancer, poses significant health risks due to its aggressive nature and potential for metastasis. The role of two-pore channel 2 (TPC2) in the development and progression of melanoma remains poorly understood ...
Ali Hanbashi +8 more
doaj +1 more source
Interrupting two-pore channels 2 (TPC2) and sperm function enhancement
, 2023 The proper functioning of sperm is essential for successful fertilization. Various physiological regulators control sperm motility, energy balance, capacitation, and the acrosomal reaction.
Kamli, Faroq
core +1 more source
P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2
Cell Reports, 2023 Summary: Upon proinflammatory challenges, endothelial cell surface presentation of the leukocyte receptor P-selectin, together with the stabilizing co-factor CD63, is needed for leukocyte capture and is mediated via demand-driven exocytosis from the ...
Jonas Goretzko +17 more
doaj +1 more source
Targeting the two-pore channel 2 in cancer progression and metastasis
Exploration of Targeted Anti-tumor Therapy, 2022 The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated.
Kathryn A. Skelding +3 more
doaj +1 more source
Two-pore channel 2 (TPC2) modulates store-operated Ca2+ entry [PDF]
, 2012 Two-pore channels (TPCs) are NAADP-sensitive receptor channels that conduct Ca2+ efflux from the intracellular stores. Discharge of the internal Ca2+ pools results in the activation of store-operated Ca2+ entry (SOCE); however, the role of TPCs in the ...
Salido, Ginés M. +5 more
core +1 more source
Cells, 2022 Two pore channels (TPCs) are implicated in vesicle trafficking, virus infection, and autophagy regulation. As Na+- or Ca2+-permeable channels, TPCs have been reported to be activated by NAADP, PI(3,5)P2, and/or high voltage.
Xinghua Feng +4 more
doaj +1 more source
A new type of oculocutaneous albinism with a novel mutation [PDF]
Yeungnam University Journal of Medicine, 2021 Oculocutaneous albinism (OCA) is a group of rare genetically heterogeneous disorders, characterized by hypopigmentation of the eyes, skin, and hair, which result in ocular abnormalities and a risk of developing skin cancer.
Sang Yoon Lee +5 more
doaj +1 more source
A two-pore channel protein required for regulating mTORC1 activity on starvation
BMC Biology, 2020 Background Two-pore channels (TPCs) release Ca2+ from acidic intracellular stores and are implicated in a number of diseases, but their role in development is unclear. The social amoeba Dictyostelium discoideum proliferates as single cells that aggregate
Fu-Sheng Chang +5 more
doaj +1 more source