Results 1 to 10 of about 1,934 (98)

TRPML Cation Channels in Inflammation and Immunity

Frontiers in Immunology, 2020
Background: In 1883, Ilya Mechnikov discovered phagocytes and established the concept of phagocytosis by macrophages. In 1908, he was awarded the Nobel Prize in Physiology/Medicine for his findings, which laid the foundations for today's understanding of
Christian Grimm, Carla Abrahamian, Yu-Kai Chao   +2 more
exaly   +3 more sources

Genome-Wide Identification of the Transient Receptor Potential Channel Family in Nile Tilapia and Expression Analysis in Response to Cold Stress [PDF]

Animals
Transient receptor potential (TRP) channels play critical roles in animals in sensing diverse stimuli, especially environmental temperature. The teleost fish Nile tilapia (Oreochromis niloticus) cannot tolerate cold temperatures.
Wanyue Deng, Yiqiong Wang, Qiong Niu, Qin Xu, Xuemei Wang, Yan Zheng, Deshou Wang, Ling Wei   +7 more
doaj   +2 more sources

TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family [PDF]

Nature Communications
TRPML2 activity is critical for endolysosomal integrity and chemokine secretion, and can be modulated by various ligands. Interestingly, two ML-SI3 isomers regulate TRPML2 oppositely.
Philip Schmiege, Dawid Jaślan, Michael Fine, Nidish Ponath Sadanandan, Alexandra Hatton, Nadia Elghobashi-Meinhardt, Christian Grimm, Xiaochun Li   +7 more
doaj   +2 more sources

Expression profiles analysis and roles in immunity of transient receptor potential (TRP) channel genes in Spodoptera frugiperda [PDF]

BMC Genomics
Background Transient receptor potential (TRP) ion channels play crucial roles in mediating responses to environmental stimuli, as well as regulating homeostasis and developmental processes in insects.
Hongai Su, Qianxuan Dai, Feiyue Teng, Ziyuan Li, Yixiang Qi, Yongyue Lu   +5 more
doaj   +2 more sources

Transient receptor potential channels in Flaviviridae infection: A comprehensive review [PDF]

Channels
Diseases caused by Flaviviridae viruses exert profound global health and economic burdens due to their high incidence and associated mortality. Infection by the Flaviviridae family often leads to severe acute or chronic illnesses, including hemorrhagic ...
Fuchun Jiang, Xiaoqiang Yao, Chang-Bo Zheng   +2 more
doaj   +2 more sources

Decoding thermal adaptation: genome-wide identification of TRP channel repertoire in cephalopods and gene expression responses to chronic thermal exposure in Sepia officinalis and Octopus maya embryos [PDF]

Frontiers in Physiology
Transient Receptor Potential (TRP) channels constitute a versatile family of membrane proteins central to sensory perception and a broad range of physiological functions.
Luis M. Molina-Carrillo, Marina Morini, Sylvie Dufour, Pavel Galindo-Torres, Sadot Ramos-Rodriguez, Carlos Rosas, Claudia Caamal-Monsreal, Clara E. Galindo-Sánchez, Gaëtan Schires, Yann Bassaglia, Yann Bassaglia, Laure Bonnaud-Ponticelli   +11 more
doaj   +2 more sources

Integrative genomic, phylogenetic, and transcriptomic analyses reveal temperature-responsive transient receptor potential (TRP) genes in Pacific abalone Haliotis discus hannai [PDF]

BMC Ecology and Evolution
Temperature profoundly influences the physiology, survival, and distribution of marine ectotherms, including mollusks. Transient receptor potential (TRP) channels are conserved thermosensory proteins in metazoans, yet their evolutionary diversification ...
Mi Ae Kim, Young Chang Sohn
doaj   +2 more sources

Functions of TRPs in retinal tissue in physiological and pathological conditions [PDF]

Frontiers in Molecular Neuroscience
The Transient Receptor Potential (TRP) constitutes a family of channels subdivided into seven subfamilies: Ankyrin (TRPA), Canonical (TRPC), Melastatin (TRPM), Mucolipin (TRPML), no-mechano-potential C (TRPN), Polycystic (TRPP), and Vanilloid (TRPV ...
Thaianne Hanah Oliveira do Nascimento, Danniel Pereira-Figueiredo, Louise Veroneze, Amanda Alves Nascimento, Francesco De Logu, Romina Nassini, Paula Campello-Costa, Adriana da Cunha Faria-Melibeu, Daniel Souza Monteiro de Araújo, Karin Costa Calaza, Karin Costa Calaza   +10 more
doaj   +2 more sources

Genome-wide identification and temperature-responsive expression profiling of TRP gene family in red swamp crayfish (Procambarus clarkii) [PDF]

BMC Genomics
Background Temperature variations significantly influence physiological processes in arthropod. The transient receptor potential (TRP) channels are key cellular sensors in the detection of temperature, pain, and mechanical stimuli.
Beiqi Yang, Yue Ma, Zishuo Bai, Qiujin Wang, Chuntong Liu, Liang Jia, Zhiyi Bai   +6 more
doaj   +2 more sources

Tissue expression of porcine transient receptor potential mucolipin protein channels and their differential responses to porcine reproductive and respiratory syndrome virus infection in vitro [PDF]

Journal of Veterinary Research
Porcine reproductive and respiratory syndrome virus (PRRSV) infection results in a serious disease, posing a huge economic threat to the global swine industry.
Xia Zhiqiang, Long Denggao, Hong Xinyi, Lan Ying, Xie Lixia   +4 more
doaj   +2 more sources