Results 11 to 20 of about 2,132 (150)
Involvement of the TRPML Mucolipin Channels in Viral Infections and Anti-viral Innate Immune Responses [PDF]
Frontiers in Immunology, 2020 The TRPML channels (TRPML1, TRPML2, and TRPML3), belonging to the mucolipin TRP subfamily, primary localize to a population of membrane-bonded vesicles along the endocytosis, and exocytosis pathways.
Giorgio Santoni +6 more
doaj +6 more sources
TrpML-mediated astrocyte microdomain Ca2+ transients regulate astrocyte–tracheal interactions [PDF]
eLife, 2020 Astrocytes exhibit spatially-restricted near-membrane microdomain Ca2+transients in their fine processes. How these transients are generated and regulate brain function in vivo remains unclear. Here we show that Drosophila astrocytes exhibit spontaneous,
Zhiguo Ma, Marc R Freeman
doaj +4 more sources
A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]
PLoS ONE, 2013 TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Zhaohua Guo +4 more
doaj +3 more sources
Emerging Role of Mucolipins TRPML Channels in Cancer [PDF]
Frontiers in Oncology, 2020 Non ...
Giorgio Santoni +6 more
doaj +6 more sources
Insects, 2021 Transient receptor potential mucolipin (TRPML) protein in flies plays a pivotal role in Ca2+ ions release, resulting in membrane trafficking, autophagy and ion homeostasis.
Haitao Wang +4 more
doaj +2 more sources
Probing roles of TRPML in Drosophila hearing [PDF]
, 2022 Several transient receptor potential (TRP) channels have been implicated in Drosophila hearing, including the TRPN channel NOMPC, the TRPVs Nan and Iav, and the TRPA members Pyx and Pain. Here I report that fly hearing also involves TRPML mucolipin channels, mutations in which are implicated in the neurodegenerative disorder mucolipidosis type IV ...
Joo, Seol-hee +8 more
openaire +4 more sources
TRPML-1 Dysfunction and Renal Tubulopathy in Mucolipidosis Type IV. [PDF]
J Am Soc NephrolKey Points Lack of transient receptor potential cation channel (TRPML-1) causes tubulopathy.Only adults affected of mucolipidosis type IV present kidney damage signs, including lower eGFR and higher levels of BUN/creatine in blood and proteinuria.TRPML-1 deficiency links lysosomal and ...
Grieco G +19 more
europepmc +7 more sources
TRPML and lysosomal function [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Mucolipin 1 (MLN1), also known as TRPML1, is a member of the mucolipin family. The mucolipins are the only lysosomal proteins within the TRP superfamily. Mutations in the gene coding for TRPML1 result in a lysosomal storage disorder (LSD). This review summarizes the current knowledge related to this protein and the rest of the mucolipin family.
Zeevi, David A. +2 more
openaire +4 more sources
Activation of TRPML Channels in the Lysosome [PDF]
Biophysical Journal, 2010 The mucolipin family of Transient Receptor Potential (TRPML) proteins is predicted to encode ion channels of intracellular endosomes and lysosomes. The physiological importance of TRPMLs has been established genetically. Mutations of human TRPML1 cause type IV mucolipidosis (ML4), a devastating neurodegenerative disease; mutations in the mouse TRPML3 ...
Xu, Haoxing +3 more
core +7 more sources
Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-Mediated Stress-Induced Neurodegenerative Diseases [PDF]
Frontiers in Physiology, 2020 Mucolipins (TRPML) are endosome/lysosome Ca2+ permeable channels belonging to the family of transient receptor potential channels. In mammals, there are three TRPML proteins, TRPML1, 2, and 3, encoded by MCOLN1-3 genes.
Giorgio Santoni +8 more
doaj +2 more sources