Results 31 to 40 of about 2,132 (150)
Identification of transient receptor potential channel genes from the swimming crab, Portunus Trituberculatus, and their expression profiles under acute temperature stress [PDF]
BMC GenomicsBackground Temperature is an important environment factor that is critical to the survival and growth of crustaceans. However, the mechanisms by which crustaceans detect changes in temperature are still unclear.
Yichen Qian +5 more
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Endolysosomal TRPMLs in Cancer [PDF]
Biomolecules, 2021 Lysosomes, the degradative endpoints and sophisticated cellular signaling hubs, are emerging as intracellular Ca2+ stores that govern multiple cellular processes. Dys-homeostasis of lysosomal Ca2+ is intimately associated with a variety of human diseases including cancer. Recent studies have suggested that the Ca2+-permeable channels Transient Receptor
Mengnan Xu, Xian-Ping Dong
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Evolutionary Aspects of TRPMLs and TPCs [PDF]
International Journal of Molecular Sciences, 2020 Transient receptor potential (TRP) or transient receptor potential channels are a highly diverse family of mostly non-selective cation channels. In the mammalian genome, 28 members can be identified, most of them being expressed predominantly in the plasma membrane with the exception of the mucolipins or TRPMLs which are expressed in the endo-lysosomal
Dawid Jaślan +3 more
openaire +2 more sources
TRPML Subfamily of Endolysosomal Channels
, 2020 Nicholas E. Karagas +2 more
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Endolysosomal Cation Channels and Lung Disease
Cells, 2022 Endolysosomal cation channels are emerging as key players of endolysosomal function such as endolysosomal trafficking, fusion/fission, lysosomal pH regulation, autophagy, lysosomal exocytosis, and endocytosis.
Barbara Spix +5 more
doaj +1 more source
Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue!
Cells, 2022 Lysosomal storage diseases (LSDs) resulting from inherited gene mutations constitute a family of disorders that disturb lysosomal degradative function leading to abnormal storage of macromolecular substrates.
Sandra Prat Castro +5 more
doaj +1 more source
Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma
Biomolecules, 2021 Microphthalmia-associated transcription factor (MITF) is the principal transcription factor regulating pivotal processes in melanoma cell development, growth, survival, proliferation, differentiation and invasion. In recent years, convincing evidence has
Carla Abrahamian, Christian Grimm
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The role of TRPMLs in endolysosomal trafficking and function [PDF]
Cell Calcium, 2015 Members of the Transient Receptor Potential-Mucolipin (TRPML) constitute a family of evolutionarily conserved cation channels that function predominantly in endolysosomal vesicles. Whereas loss-of-function mutations in human TRPML1 were first identified as being causative for the lysosomal storage disease, Mucolipidosis type IV, most mammals also ...
Kartik, Venkatachalam +2 more
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Entwicklung selektiver Aktivatoren für TRPML-Ionenkanäle [PDF]
, 2018 Plesch, Eva Veronika
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Ion Channels and Pumps in Autophagy: A Reciprocal Relationship
Cells, 2021 Autophagy, the process of cellular self-degradation, is intrinsically tied to the degradative function of the lysosome. Several diseases have been linked to lysosomal degradative defects, including rare lysosomal storage disorders and neurodegenerative ...
Hussein Abuammar +6 more
doaj +1 more source