Results 21 to 30 of about 2,132 (150)

INPP4B promotes PDAC aggressiveness via PIKfyve and TRPML-1–mediated lysosomal exocytosis [PDF]

Journal of Cell Biology
Aggressive solid malignancies, including pancreatic ductal adenocarcinoma (PDAC), can exploit lysosomal exocytosis to modify the tumor microenvironment, enhance motility, and promote invasiveness. However, the molecular pathways through which lysosomal functions are co-opted in malignant cells remain poorly understood.
Gun Ho Jang, Jonathan Tak-Sum Chow, Steven Gallinger   +2 more
exaly   +4 more sources

Endolysosomal Cation Channels and Cancer—A Link with Great Potential [PDF]

Pharmaceuticals, 2018
The endolysosomal system (ES) consists of lysosomes; early, late, and recycling endosomes; and autophagosomes. It is a key regulator not only of macromolecule degradation and recycling, plasma membrane repair, homeostasis, and lipid storage, but also of ...
Christian Grimm, Karin Bartel, Angelika M. Vollmar, Martin Biel   +3 more
doaj   +2 more sources

TRPML: Transporters of metals in lysosomes essential for cell survival? [PDF]

Cell Calcium, 2011
Key aspects of lysosomal function are affected by the ionic content of the lysosomal lumen and, therefore, by the ion permeability in the lysosomal membrane. Such functions include regulation of lysosomal acidification, a critical process in delivery and activation of the lysosomal enzymes, release of metals from lysosomes into the cytoplasm and the Ca(
Kirill, Kiselyov, Grace A, Colletti, Austen, Terwilliger, Kathleen, Ketchum, Christopher W P, Lyons, James, Quinn, Shmuel, Muallem   +6 more
openaire   +3 more sources

Therapeutic targeting of lysosome-triggered inflammatory channels in nasal and upper-airway allergic conditions [PDF]

Frontiers in Immunology
Nasal and upper airway allergic disorders, such as allergic rhinitis and allergy-associated sinus inflammation, constitute a major global health problem because of their high prevalence and significant negative impact on quality of life.
Haoran Yu, Yujin Zheng, Daquan Wu, Lei Zhou, Kanglun Jiang, Kaisai Tian, Na Shen, Na Shen   +7 more
doaj   +2 more sources

Genome-wide identification, characterization, and expression analysis of the transient receptor potential gene family in mandarin fish Siniperca chuatsi [PDF]

BMC Genomics
Background Temperature is a crucial environmental determinant for the vitality and development of teleost fish, yet the underlying mechanisms by which they sense temperature fluctuations remain largely unexplored.
Chuanrui Li, Xiaowei Qin, Mincong Liang, Zhiyong Luo, Zhipeng Zhan, Shaoping Weng, Changjun Guo, Jianguo He   +7 more
doaj   +2 more sources

HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors [PDF]

Redox Report
Background Increased lysosomal stress responses (LSR) are commonly implicated in the pathogenesis of neurodegenerative disorders including HIV-1-associated neurocognitive disorders (HAND).
Nirmal Kumar, Braelyn Liang, Jonathan D. Geiger   +2 more
doaj   +2 more sources

Extracellular domain shedding of NOTCH3 during endocytosis associated with heterogeneity between different CADASIL mutant activation mechanisms [PDF]

Cell Communication and Signaling
Background Mutations in NOTCH3 cause CADASIL, a dominantly inherited condition, linked to recurrent stroke and vascular dementia and associated with accumulation of the ECD of NOTCH3. The latter has a toxic effect on VSMCs.
Samira Hosseini-Alghaderi, Martin Baron
doaj   +2 more sources

TRPML Channels and Mucolipidosis Type IV

, 2013
The transient receptor potential (TRP) mucolipin channels TRPML1, TRPML2, and TRPML3 are non-selective cation channels predominantly found in the endolysosomal system. Mutations in the TRPML1 gene (also known as MCOLN1) cause mucolipidosis type IV in humans manifested by psychomotor abnormalities, corneal clouding, retinal degeneration, and progressive
Christian Grimm, Math P. Cuajungco
openaire   +2 more sources

A potentially dynamic lysosomal role for the endogenous TRPML proteins

The Journal of Pathology, 2009
AbstractLysosomal storage disorders (LSDs) constitute a diverse group of inherited diseases that result from lysosomal storage of compounds occurring in direct consequence to deficiencies of proteins implicated in proper lysosomal function. Pathology in the LSD mucolipidosis type IV (MLIV), is characterized by lysosomal storage of lipids together with ...
David A, Zeevi, Ayala, Frumkin, Vered, Offen-Glasner, Aviram, Kogot-Levin, Gideon, Bach   +4 more
openaire   +3 more sources

Expression of transient receptor potential channel mucolipin (TRPML) and polycystine (TRPP) in the mouse inner ear

Acta Oto-Laryngologica, 2009
TRPML3 may play distinct roles in the inner ear, such as stereociliar organization, sensory cell transduction, and inner ear fluid homeostasis, and TRPP3 may be important for fluid homeostasis in the inner ear.To study the expression of TRPML1-3 and TRPP2, 3, and 5 in the mouse inner ear.Localization of TRPML1-3 and TRPP2, 3, and 5 in the inner ear of ...
Masaya, Takumida, Matti, Anniko
openaire   +3 more sources