Results 1 to 10 of about 558 (88)

Two specific interactions of GATE16 with TRPML3 and RAB33B regulate autophagy [PDF]

Scientific Reports
ATG8s are essential for autophagy as they recruit various machinery to autophagic structures. We previously reported that the intracellular Ca2+ channel TRPML3 specifically interacts with the mammalian ATG8 homolog GATE16, but not LC3B to increase ...
Jiwoo Park, Hyun Jin Kim, Areum Choi
exaly   +3 more sources

Endolysosomal Cation Channels and Lung Disease [PDF]

Cells, 2022
Endolysosomal cation channels are emerging as key players of endolysosomal function such as endolysosomal trafficking, fusion/fission, lysosomal pH regulation, autophagy, lysosomal exocytosis, and endocytosis.
Barbara Spix, Aicha Jeridi, Meshal Ansari, Ali Önder Yildirim, Herbert B. Schiller, Christian Grimm   +5 more
doaj   +2 more sources

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice [PDF]

Nature Communications, 2022
Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the lung.
Barbara Spix, Elisabeth S. Butz, Cheng-Chang Chen, Anna Scotto Rosato, Rachel Tang, Aicha Jeridi, Veronika Kudrina, Eva Plesch, Philipp Wartenberg, Elisabeth Arlt, Daria Briukhovetska, Meshal Ansari, Gizem Günes Günsel, Thomas M. Conlon, Amanda Wyatt, Sandra Wetzel, Daniel Teupser, Lesca M. Holdt, Fabien Ectors, Ingrid Boekhoff, Ulrich Boehm, Jaime García-Añoveros, Paul Saftig, Martin Giera, Sebastian Kobold, Herbert B. Schiller, Susanna Zierler, Thomas Gudermann, Christian Wahl-Schott, Franz Bracher, Ali Önder Yildirim, Martin Biel, Christian Grimm   +32 more
doaj   +2 more sources

A Novel Ion Channel Formed by Interaction of TRPML3 with TRPV5 [PDF]

PLoS ONE, 2013
TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Christian Grimm, Stefan Heller, Anthony Ricci   +2 more
exaly   +2 more sources

Genetic Inactivation of Trpml3 Does Not Lead to Hearing and Vestibular Impairment in Mice [PDF]

PLoS ONE, 2010
TRPML3, a member of the transient receptor potential (TRP) family, is an inwardly rectifying, non-selective Ca2+-permeable cation channel that is regulated by extracytosolic Na+ and H+ and can be activated by a variety of small molecules.
Christian Grimm, Stefan Heller, Lars Becker   +2 more
exaly   +2 more sources

TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition [PDF]

The EMBO Journal
In pulmonary fibrosis lung tissue is thickened and scarred, and the lungs become progressively stiffer and smaller, leading to low levels of blood oxygen and shortness of breath. Lung fibrosis is not curable and life expectancy is reduced.
Eva-Maria Weiden, Zala Serianz, Yvonne Klingl, Simone Jörs, Dawid Jaślan, Marco Keller, Sandra Prat Castro, Mane Mkhitaryan, Aicha Jeridi, Daria Briukhovetska, Barbara Spix, Anna Scotto Rosato, Ahmed Agami, Herbert B Schiller, Suhasini Rajan, Johann Schredelseker, Giorgio Fois, Manfred Frick, Sebastian Kobold, Margarethe Klein, Fabian Geisler, Jorge Garcia-Fortanet, Leon O Murphy, Franz Bracher, Christian Wahl-Schott, Thomas Gudermann, Alexander Dietrich, Martin Biel, Ali Önder Yildirim, Christian Grimm   +29 more
doaj   +2 more sources

Expression of Transient Receptor Potential Channel Genes and Their Isoforms in Alpha‐Cells and Beta‐Cells of Human Islets of Langerhans [PDF]

Journal of Diabetes Research, Volume 2022, Issue 1, 2022., 2022
Expression of the transient receptor potential (TRP) channel genes and their isoforms in the alpha‐cells and the beta‐cells of the human islets of Langerhans has not been studied in detail. In this study, we have analyzed the RNA sequencing data obtained from purified human alpha‐cells and beta‐cells to identify the genes and their isoforms that are ...
Gabriel M. Matos, Björn Andersson, Md. Shahidul Islam, Craig S. Nunemaker   +3 more
wiley   +2 more sources

Lysosomal ion channels and pain [PDF]

PAIN Reports
. Lysosomes are recycling centers of nearly all types of eukaryotic cells. Lysosomal ion channels maintain ion homeostasis of lysosomes and exchange ions with neighboring cytoplasm and subcellular structures.
Wanxue Liu, Yiming Li, Yuhan Bao, Zhi-Yong Tan   +3 more
doaj   +2 more sources

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy [PDF]

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +2 more sources

Reduced Palmitoylation of SQSTM1/p62 in Huntington Disease Is Associated With Impaired Autophagy [PDF]

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Sequestosome 1 (SQSTM1)/p62 is a receptor for autophagy required to deliver damaged organelles and aggregated proteins to the lysosome for degradation. SQSTM1 undergoes palmitoylation, the reversible addition of the saturated fatty acid palmitate to cysteines.
F. Abrar, M. C. Davies, Y. Alshehabi, A. Kumar, A. Dang, Y. T. N. Nguyen, J. Collins, N. S. Caron, J. S. Choudhary, S. S. Sanders, M. O. Collins, M. R. Hayden, D. D. O. Martin   +12 more
wiley   +2 more sources