Results 1 to 10 of about 1,695 (109)

TRPM2 Promotes Atherosclerotic Progression in a Mouse Model of Atherosclerosis

Cells, 2022
Atherosclerosis is a chronic inflammatory arterial disease characterized by build-up of atheromatous plaque, which narrows the lumen of arteries. Hypercholesterolemia and excessive oxidative stress in arterial walls are among the main causative factors ...
Chun-Yin Lo, Xiaoqiang Yao
exaly   +4 more sources

TRPM2-Mediated Feed-Forward Loop Promotes Chondrocyte Damage in Osteoarthritis via Calcium-cGAS-STING-NF-κB Pathway

Journal of Advanced Research
Introductions: Osteoarthritis (OA) is a significant contributor to disability in the elderly population. However, current therapeutic options are limited.
Xu Jingting, Yanjun Hou, Haigang Liu
exaly   +4 more sources

Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model. [PDF]

PLoS ONE, 2013
Recent evidence suggests that transient receptor potential melastatin 2 (TRPM2) expressed in immune cells plays an important role in immune and inflammatory responses.
Kouichi Isami, Kayo Haraguchi, Kanako So, Kayoko Asakura, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko   +7 more
doaj   +3 more sources

TRPM2: Bridging Calcium and ROS Signaling Pathways—Implications for Human Diseases

Frontiers in Physiology, 2023
TRPM2 is a versatile and essential signaling molecule that plays diverse roles in Ca2+ homeostasis and oxidative stress signaling, with implications in various diseases. Research evidence has shown that TRPM2 is a promising therapeutic target.
Yassine El Hiani, El Hiani Yassine
exaly   +3 more sources

TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca2+-Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

Research, 2023
Hepatic ischemia–reperfusion (IR) injury is a serious clinical problem that complicates liver resection and transplantation. Despite recent advances in understanding of the pathophysiology of hepatic IR injury, effective interventions and therapeutics ...
Cheng Zhong, Jing Yang, Yiyin Zhang, Xiaoxiao Fan, Yang Fan, Ning Hua, Duguang Li, Shengxi Jin, Yirun Li, Peng Chen, Yongle Chen, Xiaobo Cai, Yi Zhang, Linhua Jiang, Wei Yang, Peilin Yu, Hui Lin   +16 more
doaj   +1 more source

The human ion channel TRPM2 modulates migration and invasion in neuroblastoma through regulation of integrin expression

Scientific Reports, 2022
Transient receptor potential channel TRPM2 is highly expressed in many cancers and involved in regulation of key physiological processes including mitochondrial function, bioenergetics, and oxidative stress.
Lei Bao, Fernanda Festa, Iwona Hirschler-Laszkiewicz, Kerry Keefer, Hong-Gang Wang, Joseph Y. Cheung, Barbara A. Miller   +6 more
doaj   +1 more source

Trpm2 deficiency in microglia attenuates neuroinflammation during epileptogenesis by upregulating autophagy via the AMPK/mTOR pathway

Neurobiology of Disease, 2023
Epilepsy is one of the most common neurological disorders. Neuroinflammation involving the activation of microglia and astrocytes constitutes an important and common mechanism in epileptogenesis.
Chen Chen, Tao Zhu, Lifen Gong, Zhe Hu, Hao Wei, Jianchen Fan, Donghui Lin, Xiaojun Wang, Junyu Xu, Xinyan Dong, Yifan Wang, Ningxiao Xia, Linghui Zeng, Peifang Jiang, Yicheng Xie   +14 more
doaj   +1 more source

TRPM2 Is Not Required for T-Cell Activation and Differentiation

Frontiers in Immunology, 2022
Antigen recognition by the T-cell receptor induces a cytosolic Ca2+ signal that is crucial for T-cell function. The Ca2+ channel TRPM2 (transient receptor potential cation channel subfamily M member 2) has been shown to facilitate influx of extracellular
Niels C. Lory, Niels C. Lory, Mikolaj Nawrocki, Mikolaj Nawrocki, Martina Corazza, Martina Corazza, Joanna Schmid, Valéa Schumacher, Tanja Bedke, Tanja Bedke, Stephan Menzel, Stephan Menzel, Friedrich Koch-Nolte, Andreas H. Guse, Samuel Huber, Samuel Huber, Hans-Willi Mittrücker, Hans-Willi Mittrücker   +17 more
doaj   +1 more source

Identification of TRPM2 as a Marker Associated With Prognosis and Immune Infiltration in Kidney Renal Clear Cell Carcinoma

Frontiers in Molecular Biosciences, 2022
TRPM2 (transient receptor potential melastatin-2), a Ca2+ permeable, non-selective cation channel, is highly expressed in cancers and regulates tumor cell migration, invasion, and proliferation.
Lei Sun, Zijun Zhang, Hang Zhao, Miaoyun Qiu, Ying Wen, Xiaoqiang Yao, Xiaoqiang Yao, Wai Ho Tang   +7 more
doaj   +1 more source

Long Noncoding RNA TRPM2-AS Promotes the Growth, Migration, and Invasion of Retinoblastoma via miR-497/WEE1 Axis

Frontiers in Pharmacology, 2021
Long noncoding RNAs (lncRNAs) exhibit vital roles in many types of cancer, including retinoblastoma (RB), the most common primary intraocular malignancy tumor of infancy.
Aipeng Li, Jingpu Yang, Ting Zhang, Lin Li, Miyang Li   +4 more
doaj   +1 more source