Results 1 to 10 of about 342 (129)
TRPM2 Promotes Atherosclerotic Progression in a Mouse Model of Atherosclerosis
Cells, 2022 Atherosclerosis is a chronic inflammatory arterial disease characterized by build-up of atheromatous plaque, which narrows the lumen of arteries. Hypercholesterolemia and excessive oxidative stress in arterial walls are among the main causative factors ...
Chun-Yin Lo, Xiaoqiang Yao
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TRPM2 Is Not Required for T-Cell Activation and Differentiation [PDF]
Frontiers in Immunology, 2022 Antigen recognition by the T-cell receptor induces a cytosolic Ca2+ signal that is crucial for T-cell function. The Ca2+ channel TRPM2 (transient receptor potential cation channel subfamily M member 2) has been shown to facilitate influx of extracellular
Niels C. Lory +17 more
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Journal of Advanced ResearchIntroductions: Osteoarthritis (OA) is a significant contributor to disability in the elderly population. However, current therapeutic options are limited.
Xu Jingting, Haigang Liu, Yanjun Hou
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Neuroimmune Regulation by TRPM2 Channels
CellsMutual interaction between the nervous and immune systems underpins many pathophysiological processes. Transient Receptor Potential Melastatin 2 (TRPM2) channels are abundantly expressed in both systems, acting as a critical interface of neuroimmune ...
Xuming Zhang, Mitali Malhotra
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Targeting TRPM2 in ROS-Coupled Diseases [PDF]
Pharmaceuticals, 2016 Under pathological conditions such as inflammation and ischemia-reperfusion injury large amounts of reactive oxygen species (ROS) are generated which, in return, contribute to the development and exacerbation of disease.
Shinichiro Yamamoto, Shunichi Shimizu
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TRPM2 in the Brain: Role in Health and Disease [PDF]
Cells, 2018 Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involved in the response to oxidative stress and inflammation, while its activity depends on the presence
Fabiana Morroni +2 more
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TRPM2 enhances ischemic excitotoxicity by associating with PKCγ
Cell ReportsSummary: N-methyl-D-aspartate receptor (NMDAR)-mediated glutamate excitotoxicity significantly contributes to ischemic neuronal death and post-recanalization infarction expansion.
Pengyu Zong +9 more
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Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model. [PDF]
PLoS ONE, 2013 Recent evidence suggests that transient receptor potential melastatin 2 (TRPM2) expressed in immune cells plays an important role in immune and inflammatory responses.
Kouichi Isami +7 more
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International Journal of Molecular Sciences, 2022 cADPR is a second messenger that releases Ca2+ from intracellular stores via the ryanodine receptor. Over more than 15 years, it has been controversially discussed whether cADPR also contributes to the activation of the nucleotide-gated cation channel TRPM2.
Winnie Maria Riekehr +6 more
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TRPM2 and warmth sensation [PDF]
Pflügers Archiv - European Journal of Physiology, 2018 The abilities to detect warmth and heat are critical for the survival of all animals, both in order to be able to identify suitable thermal environments for the many different activities essential for life and to avoid damage caused by extremes of temperature.
Chun-Hsiang Tan, Peter A. McNaughton
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