TRPM2-AS promotes the malignancy of osteosarcoma cells by targeting miR-15b-5p/PPM1D axis
, 2022 Osteosarcoma (OS) is a malignant tumor with a low survival rate and a high incidence rate worldwide. Although research has reported the involvement of long non-coding RNAs (lncRNAs) in the pathogenesis of OS cells, the role of TRPM2-AS, miR-15b-5p, and ...
Yingchun Cai (3809575) +4 more
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Function and modulation of TRPM2 channels [PDF]
, 2013 Melastatin-related transient receptor potential 2 (TRPM2) channel is a Ca2+-permeable cation channel that is gated by ADP-ribose (ADPR) and also activated by reactive oxygen species (ROS) such as H2O2. TRPM2 channel are shown to be critically involved in
Zou, Jie
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TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide
, 2021 Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable ...
Chun-Hsiang Tan +5 more
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Role of TRPM2 in H(2)O(2)-induced cell apoptosis in endothelial cells. [PDF]
PLoS ONE, 2012 Melastatin-like transient receptor potential channel 2 (TRPM2) is an oxidant-sensitive and cationic non-selective channel that is expressed in mammalian vascular endothelium. Here we investigated the functional role of TRPM2 channels in hydrogen peroxide
Lei Sun +5 more
doaj +1 more source
The vital role of TRPM2 in breast cancer cell proliferation and its difference in expression between non-Hispanic white and non-Hispanic black females [PDF]
World Cancer Research JournalObjective: To study the racial disparity of transient receptor potential melastatin-related channel subtype 2 (TRPM2) expression in non-Hispanic black (NHB) women and non-Hispanic white women (NHW) breast cancer tissues.
L. Huang, Y. Lu, M. Li
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Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models
Journal of Pharmacological Sciences, 2015 Recent evidence suggests a role of transient receptor potential melastatin 2 (TRPM2) in immune and inflammatory responses. We previously reported that TRPM2 deficiency attenuated inflammatory and neuropathic pain in some pain mouse models, including ...
Kanako So +8 more
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Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer
Journal of Ovarian Research, 2023 Introduction Ovarian cancer (OC) is one of the most common gynecologic malignant cancers with the current survival rate remaining low. TRPM2 has been reported as a survival predictor in various cancers but not in OC.
Wei Huang +9 more
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TRPM2 promotes pancreatic cancer by PKC/MAPK pathway
Cell Death and Disease, 2021 The mechanism of pancreatic cancer (PA) is not fully understanded. In our last report, TRPM2 plays a promising role in pancreatic cancer. However, the mechanism of TRPM2 is still unknown in this dismal disease.
Rui Lin +7 more
doaj +1 more source
The Janus-faced role of TRPM2-S in retroperitoneal liposarcoma via increasing ROS levels
Cell Communication and Signaling, 2022 Background Retroperitoneal liposarcoma (RPLS) is a specific soft tissue sarcoma with a high recurrence rate. The short isoform of transient receptor potential cation channel subfamily M member 2 (TRPM2-S) plays an important role in the regulation of ...
Xiangji Li +7 more
doaj +1 more source
, 2022 cADPR is a second messenger that releases Ca2+ from intracellular stores via the ryanodine receptor. Over more than 15 years, it has been controversially discussed whether cADPR also contributes to the activation of the nucleotide-gated cation channel ...
Andreas Bauche +6 more
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