Results 21 to 30 of about 1,608 (146)
Neurobiology of Disease, 2023 Epilepsy is one of the most common neurological disorders. Neuroinflammation involving the activation of microglia and astrocytes constitutes an important and common mechanism in epileptogenesis.
Chen Chen +14 more
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TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide
, 2021 Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable ...
Chun-Hsiang Tan +5 more
core +1 more source
Cell Calcium, 2019 The TRP ion channel TRPM2 has an essential function in cell survival and protects the viability of a number of cell types after oxidative stress. It is highly expressed in many cancers including breast, prostate, and pancreatic cancer, melanoma, leukemia, and neuroblastoma, suggesting it promotes cancer cell survival.
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Nature Cardiovascular Research, 2022 Atherosclerosis is the major cause of ischemic heart disease and stroke, the leading causes of mortality worldwide. The central pathological features of atherosclerosis include macrophage infiltration and foam cell formation. However, the detailed mechanisms regulating these two processes remain unclear. Here we show that oxidative stress-activated Ca2+
Pengyu Zong +8 more
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Frontiers in Molecular Biosciences, 2022 TRPM2 (transient receptor potential melastatin-2), a Ca2+ permeable, non-selective cation channel, is highly expressed in cancers and regulates tumor cell migration, invasion, and proliferation.
Lei Sun +7 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Long noncoding RNAs (lncRNAs) exhibit vital roles in many types of cancer, including retinoblastoma (RB), the most common primary intraocular malignancy tumor of infancy.
Aipeng Li +4 more
doaj +1 more source
TRPM2 deficiency protects against atherosclerosis by inhibiting TRPM2-CD36 inflammatory axis in macrophages [PDF]
, 2021 ABSTRACT Atherosclerosis is the major cause of ischemic heart diseases and ischemic brain stroke, which are the leading causes of mortality worldwide. The central pathological features of atherosclerosis include macrophage infiltration and foam cell formation.
Pengyu Zong +5 more
openaire +1 more source
TRPM2 Channel-Mediated Signalling Mechanisms for Neuronal Cell Death [PDF]
, 2017 Transient receptor potential melastatin-related 2 (TRPM2) channel is gated by ADP-ribose (ADPR) and potently activated by reactive oxygen species (ROS) through stimulating ADPR-generating mechanisms. Recent studies provide evidence to show a crucial role
Li, Xin
core +7 more sources
Role of TRPM2 in H(2)O(2)-induced cell apoptosis in endothelial cells. [PDF]
PLoS ONE, 2012 Melastatin-like transient receptor potential channel 2 (TRPM2) is an oxidant-sensitive and cationic non-selective channel that is expressed in mammalian vascular endothelium. Here we investigated the functional role of TRPM2 channels in hydrogen peroxide
Lei Sun +5 more
doaj +1 more source
Cell Research, 2016 Two recent studies reveal a crucial role for the cation channel TRPM2 in sensing warm temperatures, both in the thermoregulatory center of the brain and in the somatosensory system.
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