Results 1 to 10 of about 4,329 (116)

Neuroimmune Regulation by TRPM2 Channels [PDF]

Cells
Mutual interaction between the nervous and immune systems underpins many pathophysiological processes. Transient Receptor Potential Melastatin 2 (TRPM2) channels are abundantly expressed in both systems, acting as a critical interface of neuroimmune ...
Xuming Zhang, Mitali Malhotra
doaj   +2 more sources

Pathophysiological significance of the TRPM2 ion channel as a potential target in cancer, neurological disorders, and ischemia/reperfusion injury [PDF]

Pharmacological Research
The transient receptor potential melastatin 2 (TRPM2) ion channel is a redox-sensitive, non-specific cation channel that plays a vital role in the regulation of Ca2+ homeostasis and cellular functions in response to oxidative stress.
Sara Sultana, Yang Xie, Mir Shahriar Kamal, Wei Li   +3 more
doaj   +2 more sources

TRPM2: a pivotal player in tumor progression and a promising therapeutic target [PDF]

Cancer Cell International
TRPM2, a member of the TRPM family, is a ubiquitously expressed non-selective cation channel located on cellular membranes. Activated by ADP-ribose (ADPR), this channel is prevalent across various normal tissues and plays a critical role in numerous ...
Zhigang Chen, Zhenheng Wu, Tianhan Xu, Fuqian Yu, Dongmei Wang   +4 more
doaj   +2 more sources

Long Noncoding RNA TRPM2-AS Promotes the Growth, Migration, and Invasion of Retinoblastoma via miR-497/WEE1 Axis

Frontiers in Pharmacology, 2021
Long noncoding RNAs (lncRNAs) exhibit vital roles in many types of cancer, including retinoblastoma (RB), the most common primary intraocular malignancy tumor of infancy.
Aipeng Li, Jingpu Yang, Ting Zhang, Lin Li, Miyang Li   +4 more
doaj   +1 more source

Identification of TRPM2 as a Marker Associated With Prognosis and Immune Infiltration in Kidney Renal Clear Cell Carcinoma

Frontiers in Molecular Biosciences, 2022
TRPM2 (transient receptor potential melastatin-2), a Ca2+ permeable, non-selective cation channel, is highly expressed in cancers and regulates tumor cell migration, invasion, and proliferation.
Lei Sun, Zijun Zhang, Hang Zhao, Miaoyun Qiu, Ying Wen, Xiaoqiang Yao, Xiaoqiang Yao, Wai Ho Tang   +7 more
doaj   +1 more source

TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca2+-Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

Research, 2023
Hepatic ischemia–reperfusion (IR) injury is a serious clinical problem that complicates liver resection and transplantation. Despite recent advances in understanding of the pathophysiology of hepatic IR injury, effective interventions and therapeutics ...
Cheng Zhong, Jing Yang, Yiyin Zhang, Xiaoxiao Fan, Yang Fan, Ning Hua, Duguang Li, Shengxi Jin, Yirun Li, Peng Chen, Yongle Chen, Xiaobo Cai, Yi Zhang, Linhua Jiang, Wei Yang, Peilin Yu, Hui Lin   +16 more
doaj   +1 more source

Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer

Journal of Ovarian Research, 2023
Introduction Ovarian cancer (OC) is one of the most common gynecologic malignant cancers with the current survival rate remaining low. TRPM2 has been reported as a survival predictor in various cancers but not in OC.
Wei Huang, Yuliang Wu, Ning Luo, Xueqian Shuai, Jing Guo, Chunyan Wang, Fanchun Yang, Li Liu, Shupeng Liu, Zhongping Cheng   +9 more
doaj   +1 more source

LncTRPM2-AS inhibits TRIM21-mediated TRPM2 ubiquitination and prevents autophagy-induced apoptosis of macrophages in asthma

Cell Death and Disease, 2021
Long non-coding RNAs (lncRNAs) play a crucial role in macrophage development but little is known about their role in asthma. Here, we investigated the role of lncRNA lncTRPM2-AS in asthma and found that lncTRPM2-AS participates in the promotion of ...
Xiaoping Li, Wenwen Wang, Yu Shao, Ji Zhou, Jiaqi Huang, Fei Xu, Xiu Gao, Mengyun Wu, Yongli Dong, Wenyan Wu, Jiamin Cai, Junyao Wang, Yunfei Ye, Zhengrong Chen, Chuangli Hao, Yi Yang, Jinping Zhang   +16 more
doaj   +1 more source

Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death

Frontiers in Molecular Neuroscience, 2017
Transient receptor potential melastatin-related 2 (TRPM2) channel, a molecular sensor for reactive oxygen species (ROS), plays an important role in cognitive dysfunction associated with post-ischemia brain damage thought to result from ROS-induced TRPM2 ...
Xin Li, Wei Yang, Wei Yang, Lin-Hua Jiang, Lin-Hua Jiang   +4 more
doaj   +1 more source

Targeting TRPM2 in ROS-Coupled Diseases

Pharmaceuticals, 2016
Under pathological conditions such as inflammation and ischemia-reperfusion injury large amounts of reactive oxygen species (ROS) are generated which, in return, contribute to the development and exacerbation of disease.
Shinichiro Yamamoto, Shunichi Shimizu
doaj   +1 more source