Results 21 to 30 of about 60,512,053 (199)
Crosstalk Between Vascular Redox and Calcium Signaling in Hypertension Involves TRPM2 (Transient Receptor Potential Melastatin 2) Cation Channel [PDF]
, 2020 Increased generation of reactive oxygen species (ROS) and altered Ca2+ handling cause vascular damage in hypertension. Mechanisms linking these systems are unclear, but TRPM2 (transient receptor potential melastatin 2) could be important because TRPM2 is
Karla B. Neves +6 more
core +2 more sources
Function and modulation of TRPM2 channels [PDF]
, 2013 Melastatin-related transient receptor potential 2 (TRPM2) channel is a Ca2+-permeable cation channel that is gated by ADP-ribose (ADPR) and also activated by reactive oxygen species (ROS) such as H2O2. TRPM2 channel are shown to be critically involved in
Zou, Jie
core +5 more sources
TRPM2 and warmth sensation [PDF]
Pflügers Archiv - European Journal of Physiology, 2018 The abilities to detect warmth and heat are critical for the survival of all animals, both in order to be able to identify suitable thermal environments for the many different activities essential for life and to avoid damage caused by extremes of temperature.
Chun-Hsiang Tan, Peter A. McNaughton
openaire +3 more sources
, 2006 TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and nitrosative stress. To date studies of
Benham, C.D. +6 more
core +4 more sources
Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin. [PDF]
J PhysiolAbstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Alemayhu AM, Paulsen CE.
europepmc +2 more sources
TRPM2-AS promotes the malignancy of osteosarcoma cells by targeting miR-15b-5p/PPM1D axis
, 2022 Osteosarcoma (OS) is a malignant tumor with a low survival rate and a high incidence rate worldwide. Although research has reported the involvement of long non-coding RNAs (lncRNAs) in the pathogenesis of OS cells, the role of TRPM2-AS, miR-15b-5p, and ...
Yingchun Cai (3809575) +4 more
core +1 more source
TRPM2: Shredding the mitochondrial network [PDF]
Channels, 2017 Mitochondria, traditionally known for their role in power (ATP) generation, are important signalling organelles.
Li, F, Abuarab, N, Sivaprasadarao, A
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Cell Calcium, 2019 The TRP ion channel TRPM2 has an essential function in cell survival and protects the viability of a number of cell types after oxidative stress. It is highly expressed in many cancers including breast, prostate, and pancreatic cancer, melanoma, leukemia, and neuroblastoma, suggesting it promotes cancer cell survival.
openaire +2 more sources
The Role of TRPM2 in Endothelial Function and Dysfunction
International Journal of Molecular Sciences, 2021 The transient receptor potential (TRP) melastatin-like subfamily member 2 (TRPM2) is a non-selective calcium-permeable cation channel. It is expressed by many mammalian tissues, including bone marrow, spleen, lungs, heart, liver, neutrophils, and endothelial cells.
Wioletta Zielińska +3 more
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TRPM2 deficiency protects against atherosclerosis by inhibiting TRPM2-CD36 inflammatory axis in macrophages [PDF]
, 2021 ABSTRACT Atherosclerosis is the major cause of ischemic heart diseases and ischemic brain stroke, which are the leading causes of mortality worldwide. The central pathological features of atherosclerosis include macrophage infiltration and foam cell formation.
Pengyu Zong +5 more
openaire +1 more source