Results 11 to 20 of about 60,512,053 (199)

cADPR Does Not Activate TRPM2

International Journal of Molecular Sciences, 2022
cADPR is a second messenger that releases Ca2+ from intracellular stores via the ryanodine receptor. Over more than 15 years, it has been controversially discussed whether cADPR also contributes to the activation of the nucleotide-gated cation channel TRPM2.
Winnie Maria Riekehr, Simon Sander, Jelena Pick, Henning Tidow, Andreas Bauche, Andreas H. Guse, Ralf Fliegert   +6 more
openaire   +3 more sources

TRPM2-AS promotes ovarian cancer cell proliferation and inhibits cell apoptosis by upregulating the nearby gene TRPM2 via miR-6764-5p

Cell Division
Ovarian cancer (OC) becomes a fatal gynecologic malignant cancer in females worldwide. Target therapy is a promising therapeutical choice for patients with OC, and identifying biomarkers and exploring molecular mechanisms are necessary.
Wei Zhu, Shiqin Mao, Juan Jiang
doaj   +2 more sources

Identification of Ligands for Ion Channels: TRPM2

ChemBioChem
AbstractTransient receptor potential melastatin 2 (TRPM2) is a calcium‐permeable, nonselective cation channel with a widespread distribution throughout the body. It is involved in many pathological and physiological processes, making it a potential therapeutic target for various diseases, including Alzheimer's disease, Parkinson's disease, and cancers.
Yushu Gu, Miaomiao Liu, Linlin Ma, Ronald J. Quinn   +3 more
openaire   +4 more sources

Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers

Technology in Cancer Research & Treatment
Long non-coding RNAs (lncRNAs) are known to play vital roles in human cancers. LncRNA TRPM2-AS has been found to be upregulated in various types of cancers. The elevated levels of TRPM2-AS are associated with important clinicopathological parameters such
Shichen Huang MS, Bowen Li MS, Huanyu Chen MD, Cheng Rong, Zheng Yang MD, Xianqin Zhang PhD   +5 more
doaj   +2 more sources

TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide

Scientific Reports, 2021
Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable ...
Hassan Morad, Suaib Luqman, Chun-Hsiang Tan, Victoria Swann, Peter A. McNaughton   +4 more
doaj   +2 more sources

Downregulation of a novel long noncoding RNA TRPM2-AS promotes apoptosis in non–small cell lung cancer

Tumor Biology, 2017
Non–small cell lung cancer is one of the most common types of cancer, and the prognosis of non–small cell lung cancer is still poor. Recent evidence has proved that long noncoding RNA is involved in tumorigenesis.
Cheng Huang, Yingzhi Qin, Hongsheng Liu, Naixin Liang, Yeye Chen, Dongjie Ma, Zhijun Han, Xiaohui Xu, Xiaoyun Zhou, Jia He, Shanqing Li   +10 more
doaj   +2 more sources

TRPM2 overactivation drives hyperlipidemia-induced dysfunction of myeloid cells and neurovascular units [PDF]

Cell Reports Medicine
Summary: Hyperlipidemia induces cellular dysfunction and is strongly linked to various diseases. The transient receptor potential channel melastatin 2 (TRPM2) plays a critical role in endothelial injury, immune cell activation, and neuronal death.
Pengyu Zong, Cindy Li, Jianlin Feng, Zhichao Yue, Nicholas Legere, Albert S. Yu, Fahad Shah, Adrianna Perez, Zhu Li, Evan Jellison, Yasuo Mori, Barbara Miller, Rajkumar Verma, Bruce Liang, Lixia Yue   +14 more
doaj   +2 more sources

TRPM2 in the Brain: Role in Health and Disease [PDF]

Cells, 2018
Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized.
Giulia Sita, Patrizia Hrelia, Agnese Graziosi, Gloria Ravegnini, Fabiana Morroni   +4 more
doaj   +3 more sources

TRPM2 is a direct pain transducer. [PDF]

Proc Natl Acad Sci U S A
Chronic pain results from maladaptive interaction between the immune and nervous systems. TRPM2 channels in immune cells (immune TRPM2) are believed to facilitate chronic pain by indirectly promoting immune-inflammatory responses, whereas TRPM2 in sensory neurons (neuronal TRPM2) acts as a warmth sensor critical to sense innocuous ...
Varghese L, Alizada M, Yang J, Feng Y, Yuan X, Malhotra M, Zhang X.   +6 more
europepmc   +4 more sources

The TRPM2-PARP-1 Axis Involvement in Bisphenol A and Nonylphenol-Induced Ferroptosis in Trigeminal Ganglion Cells. [PDF]

J Appl Toxicol
ABSTRACT Environmental contaminants like bisphenol A (BPA) and nonylphenol (NP) are recognized neurotoxicants; however, the molecular mechanisms underlying their impact on sensory ganglia, specifically the trigeminal ganglion (TG), remain critically underexplored.
Yazğan B, Tatar M, Yazğan Y, Tüfekci KK.   +3 more
europepmc   +2 more sources