Results 1 to 10 of about 4,187 (118)
Shigella IpaA mediates actin bundling through diffusible vinculin oligomers with activation imprint
Cell Reports, 2023 Summary: Upon activation, vinculin reinforces cytoskeletal anchorage during cell adhesion. Activating ligands classically disrupt intramolecular interactions between the vinculin head and tail domains that bind to actin filaments.
Cesar Valencia-Gallardo +17 more
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The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis
Scientific Reports, 2021 Regulation of Ca2+ signaling is critical for the progression of cell division, especially during meiosis to prepare the egg for fertilization. The primary Ca2+ influx pathway in oocytes is Store-Operated Ca2+ Entry (SOCE).
Rawad Hodeify +9 more
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Experimental and Molecular Medicine, 2023 Hepatic glucose production by glucagon is crucial for glucose homeostasis during fasting, yet the underlying mechanisms remain incompletely delineated. Although CD38 has been detected in the nucleus, its function in this compartment is unknown.
So-Young Rah +6 more
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Mitochondrial Ca2+ signaling [PDF]
Pharmacology & Therapeutics, 2018 Mitochondrial Ca2+ regulation is crucial for bioenergetics and cellular signaling. The mechanisms controlling mitochondrial calcium homeostasis have been recently unraveled with the discovery of mitochondrial inner membrane proteins that regulate mitochondrial Ca2+ uptake and extrusion.
Trayambak, Pathak, Mohamed, Trebak
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PLoS Computational Biology, 2021 Information flow within and between cells depends significantly on calcium (Ca2+) signaling dynamics. However, the biophysical mechanisms that govern emergent patterns of Ca2+ signaling dynamics at the organ level remain elusive.
Dharsan K. Soundarrajan +4 more
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The Physiopathologic Roles of Calcium Signaling in Podocytes
Frontiers in Bioscience-Landmark, 2023 Calcium (Ca2+) plays a critical role in podocyte function. The Ca2+-sensitive receptors on the cell surface can sense changes in Ca2+ concentration, and Ca2+ flow into podocytes, after activation of Ca2+ channels (such as transient receptor potential ...
Yu-Chi Tu +6 more
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Fundamental properties of Ca2+ signals [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012 Ca2+ is a ubiquitous and versatile second messenger that transmits information through changes of the cytosolic Ca2+ concentration. Recent investigations changed basic ideas on the dynamic character of Ca2+ signals and challenge traditional ideas on information transmission.We present recent findings on key characteristics of the cytosolic Ca2 ...
Kevin, Thurley +3 more
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Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis
Cell Reports, 2020 Summary: The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During the
Yeonsoo Joe +11 more
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Calcium signaling and transport machinery: Potential for development of stress tolerance in plants
Current Plant Biology, 2022 Calcium (Ca2+) is an essential macronutrient as well as a second messenger in diverse biological processes in plants. Plants perceive various stimuli which leads to transient increase in cytosolic calcium [Ca2+]cyt levels, resulting in generation of Ca2+
Soma Ghosh +3 more
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Cytosolic and mitochondrial Ca2+ signaling in procoagulant platelets
Platelets, 2021 Platelets are the major cellular contributor to arterial thrombosis. However, activated platelets form two distinct subpopulations during thrombosis. Pro-aggregatory platelets aggregate to form the main body of the thrombus.
Sarah L. Millington-Burgess +1 more
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